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Handbook of Psychopharmacology pp 197–219Cite as

Reserpine: Basic and Clinical Pharmacology

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Abstract

The introduction, somewhat more than two decades ago, of reserpine as a purified alkaloid of Rauwolfia has contributed greatly to the remarkable advances in the emerging field of psychopharmacology. Notwithstanding the disappearance of the use of reserpine in clinical psychiatry, owing largely to its overshadowing by better drugs, reserpine has made its mark in the stimulation of investigative work and in its continuing use as a tool in the understanding of the mode of action of psychoactive drugs and of the functioning of central monoaminergic neuronal systems and the peripheral adrenergic nervous system. Reserpine rightly deserves historical recognition as one of those key drugs, like nicotine or muscarine, which has allowed a “quantum jump” in our knowledge of the nervous system.

Keywords

  • Biogenic Amine
  • SYRINGIC Acid
  • Adrenergic Neuron
  • Reserpine Treatment
  • Amine Uptake

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  1. Department of Pharmacology, University of Texas Health Science Center, Dallas, Texas, 75235, USA

    Parkhurst A. Shore & Antonio Giachetti

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  1. Parkhurst A. Shore
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Editors and Affiliations

  1. Department of Pharmacology, University of Cambridge, USA

    Leslie L. Iversen

  2. Department of Psychology, University of Cambridge, USA

    Susan D. Iversen

  3. Departments of Pharmacology and Psychiatry, The Johns Hopkins University School of Medicine, USA

    Solomon H. Snyder

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Shore, P.A., Giachetti, A. (1978). Reserpine: Basic and Clinical Pharmacology. In: Iversen, L.L., Iversen, S.D., Snyder, S.H. (eds) Handbook of Psychopharmacology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4042-3_6

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