Reserpine: Basic and Clinical Pharmacology

  • Parkhurst A. Shore
  • Antonio Giachetti


The introduction, somewhat more than two decades ago, of reserpine as a purified alkaloid of Rauwolfia has contributed greatly to the remarkable advances in the emerging field of psychopharmacology. Notwithstanding the disappearance of the use of reserpine in clinical psychiatry, owing largely to its overshadowing by better drugs, reserpine has made its mark in the stimulation of investigative work and in its continuing use as a tool in the understanding of the mode of action of psychoactive drugs and of the functioning of central monoaminergic neuronal systems and the peripheral adrenergic nervous system. Reserpine rightly deserves historical recognition as one of those key drugs, like nicotine or muscarine, which has allowed a “quantum jump” in our knowledge of the nervous system.


Biogenic Amine SYRINGIC Acid Adrenergic Neuron Reserpine Treatment Amine Uptake 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Parkhurst A. Shore
    • 1
  • Antonio Giachetti
    • 1
  1. 1.Department of PharmacologyUniversity of Texas Health Science CenterDallasUSA

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