Behavioral Actions of Neuroleptics

  • Stuart Fielding
  • Harbans Lal


The term “neuroleptic” was proposed by Jean Delay and Pierre Deniker in 1955 to the French Academy of Medicine. Delay and Deniker defined a neuroleptic as an agent which induced a syndrome of behavioral and psychic symptoms that is observed in patients after administration of chlorpromazine-like drugs. By this definition, the neuroleptic drugs are those chemical substances which produce a characteristic neuroleptic syndrome in man as, at that time, the typical effects of these drugs in animals were not known. It may be pointed out that the neuroleptic syndrome is a rather acute effect of these drugs. The long-term effect that is desired of neuroleptics is to provide a cure for schizophrenia.


Avoidance Behavior Behavioral Action Lateral Hypothalamus Anticholinergic Drug Neuroleptic Drug 
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  1. ANDEN, M. E., BUTCHER, S., CORRODI, H., FUXE, K., and UNGERSTEDT, U., 1970, Receptor activity and turnover of dopamine and noradrenaline after neuroleptics, Eur. J. Pharmacol. 11:303–314.PubMedCrossRefGoogle Scholar
  2. BOSHKA, S. E., WEISSMAN, M. C., and THOR, D. H., 1966, A technique for inducing aggression in rats utilizing morphine withdrawal, Phychol. Rec. 16:541–543.Google Scholar
  3. BUTTERWORTH, R. F., POIGNANT, J. C., and BARBEAU, A., 1975, Apomorphine and piribedil in rats: Biochemical and pharmacologic studies, in: Advances in Neurology, Vol. 9, Dopaminergic Mechanisms (D. Calne, T. N. Chase, and A. Barbeau, eds.), pp. 307–326, Raven Press, New York.Google Scholar
  4. CARLSSON, A., and LINDQVIST, M., 1963, Effect of chlorpromazine and haloperidol on formation of 3-methoxytyramine and normetanephrine in mouse brain, Acta Pharmacol. 20:140–144.CrossRefGoogle Scholar
  5. CARLINI, E. A., and GONZALEZ, C., 1972, Aggressive behavior induced by marijuana compounds and amphetamine in rats previously made dependent on morphine, Experientia 28:542–544.PubMedCrossRefGoogle Scholar
  6. CLAY, G. A., and BROUGHAM, L. R., 1975, Haloperidol binding to an opiate receptor site, Biochem. Pharmacol. 24:1363–1367.PubMedCrossRefGoogle Scholar
  7. COLPAERT, F. C., WAUQUIER, A., NIEMEGEERS, C., and LAL, H., 1975, Reversal by a central antiacetylcholine drug of pimozide-induced inhibition of mouse jumping in amphetamine-dopa treated mice, J. Pharrn. Pharmacol. 27:536–537.CrossRefGoogle Scholar
  8. Cox, B., ARY, M., and LOMAX, P., 1975, Dopaminergic mechanism in withdrawal hypothermia in morphine dependent rats, Life Sci. 17:41–42.PubMedCrossRefGoogle Scholar
  9. CREESE, I., FEINBERG, A., and SNYDER, S. H., 1976, Butyrophenone influence on the opiate receptor, Europ. J. Pharmacol. 36:231–235.CrossRefGoogle Scholar
  10. DIABAC, A., 1973, Apomorphine-induced aggressivity in rats and its alterations, Act. Nerv. Suppl. 15:133.Google Scholar
  11. EICHELMAN, B. S., and THOA, N. B., 1973, The aggressive monoamines, Biol. Psychiatr. 6:143–163.Google Scholar
  12. FIELDING, S., OUTWATER, B., MREEVY, T., and PACIFICO, L., 1972, Investigation of extrapyramidal toxicity and depression of shock avoidance behavior by neuroleptic drugs, Toxicol. Appl. Pharmacol. 22:159–160.Google Scholar
  13. FIELDING, S., MARKY, M., and LAL, H., 1975, Elicitation of mouse jumping by combined treatment with amphetamine and L-DOPA: Blockade by known neuroleptics, Pharmacologist 17:210.Google Scholar
  14. FLOREA, J., and THOR, D. H., 1968, Drug withdrawal and fighting in rats, Psychon. Sci. 12:33.Google Scholar
  15. GIANUTSOS, G., DRAWBAUGH, R. B., HYNES, M. D., and LAL, H., 1974, Behavioral evidence for dopaminergic supersensitivity after chronic haloperidol, Life Sci. 14:887–898.PubMedCrossRefGoogle Scholar
  16. GOLDSTEIN, A., and SCHULZ, R., 1973, Morphine tolerant longitudinal muscle strip from guinea pig ileum., Br. J. Pharmacol. 48:655–666.PubMedGoogle Scholar
  17. HAASE, H. J., and JANSSEN, P. A. J., 1965, The Action of Neuroleptic Drugs, p. 3, Year Book Publishers, Inc., Chicago.Google Scholar
  18. HANSON, H. M., and CIMINI-VENOMA, C.A., 1972, Effect of haloperidol on self-administration of morphine in rats. Fed. Proc. 3:503.Google Scholar
  19. HANSON, H. M., STONE, C. A., and WITOSLASKI, J. J., 1970, Antogonism of the anti-avoidance effects of various agents by anticholinergic drugs, J. Pharmacol. Exp. Ther. 173:117–124.PubMedGoogle Scholar
  20. HOFFMEISTER, F., 1975, Negative reinforcing properties of some psychoactive drugs in drug naive rhesus monkeys, J. Pharmacol. Exp. Ther. 192:408–477.Google Scholar
  21. HYNES, M. D., ANDERSON, C. D., GIANUTSOS, G., and LAL, H., 1975, Effects of haloperidol, methyltyrosine and morphine on recovery from lesions of lateral hypothalamus, Pharmacol. Biochem. Behav. 3:755–759.PubMedCrossRefGoogle Scholar
  22. IORIO, L. C., DEACON, M. A., and RYAN, E. A., 1975, Blockade by narcotic drugs of naloxone-precipitated jumping in morphine dependent mice, J. Pharmacol. Exp. Ther. 192:58–63.PubMedGoogle Scholar
  23. JANSSEN, P. A. J., JAGENEAU, A. H., and NIEMEGEERS, C.J. E., 1960, Effects of various drugs on isolation-induced fighting behavior of male mice, J. Pharmacol. Exp. Ther. 129:471–475.PubMedGoogle Scholar
  24. JANSSEN, P. A. J., NIEMEGEERS, C. J. E., and SCHELLEBENS, K. H. L., 1965, Is it possible to predict the clinical effects of neuroleptic drugs from animal data., Arzneim. Forsch. 15:104–117.Google Scholar
  25. JANSSEN, P. A. J., NIEMEGEERS, C. J. E., SCHELLEKENS, K. H. L., LENAERTS, F. M., and WAUQUIER, A., 1975, Clopimozide, a new highly potent and orally long acting neuroleptic of the diphenylbutylpiperidine series, Arzneim. Forsch. 25:1287–1294.Google Scholar
  26. KARKALAS, J., and LAL, H., 1973, A comparison of haloperidol with methadone in blocking heroin withdrawal symptoms, Int. Pharmacopsychiatr. 8:248–251.Google Scholar
  27. LAL, H., 1975a, Narcotic dependence, narcotic action and dopamine receptors, Life Sci. 17:483–496.PubMedCrossRefGoogle Scholar
  28. LAL, H., 1975b, Morphine-withdrawal aggression, in: Methods in Narcotic Research (S. Ehrenpreis and E. A. Neidle, eds.), pp. 171–183, Marcel Dekker, New York.Google Scholar
  29. LAL, H., and HYNES, M. D. 1977, Effectiveness of butyrophenones and related drugs in narcotic withdrawal, Proceedings Collegium International Neuro-Psychopharmacologium (P. Deniker, C. Radouco-Thomas, and A. Villeneuve, eds.), Pergamon Press, New York.Google Scholar
  30. LAL, H., and NUMAN, R., 1976, Blockade of morphine-withdrawal body shakes by haloperidol, Life Sci. 18:163–168.PubMedCrossRefGoogle Scholar
  31. LAL, H., DEFEO, J. I., and THUT, P., 1968, Effect of amphetamine on pain induced aggression, Comm. Behav. Biol. 1:333–336.Google Scholar
  32. LAL, H., O’BRIEN, J., and PURI, S. K., 1971, Morphine-withdrawal aggression: Sensitization by amphetamine, Psychopharmacologia 22:217–223.PubMedCrossRefGoogle Scholar
  33. LAL, H., DEFEO, J. J., PITTERMAN, A., PATEL, G., and BAUMEL, I., 1972a, Effects of prolonged social deprivation or enrichment on neuronal sensitivity for CNS depressants and stimulant, in: Drug Addiction, Vol. 1 (J. M. Singh, L. H. Miller, and H. Lal, eds.), pp. 255–266, Futura Publishing, Mt. Kisco, New York.Google Scholar
  34. LAL, H., O’BRIEN, J., PITTERMAN, A., GIANUTSOS, G., and REDDY, C., 1972b, Aggression after amphetamines and dihydroxyphenylalanine, Fed. Proc. 13:529.Google Scholar
  35. LAL, H., COLPAERT, F. C., and LADURON, P., 1975a, Narcotic withdrawal-like mouse jumping produced by amphetamine and L-DOPA, Europ. J. Pharmacol. 30:113–116.CrossRefGoogle Scholar
  36. LAL, H., GIANUTSOS, G., and PURI, S. K., 1975b, Comparison of narcotic analgesics with neuroleptics on behavior measures of dopaminergic act, Life Sci. 17:29–34.PubMedCrossRefGoogle Scholar
  37. LAL, H., WAUGUIER, A., and NIEMEGEERS, C. J. E., 1975c, Characteristics of narcotic dependence by oral ingestion of fentanyl solution, Pharmacologist 17:237.Google Scholar
  38. LAL, H., MARKY, M., and FIELDING, S., 1976, Effect of neuroleptic drugs on mouse jumping induced by L-DOPA in amphetamine treated mice, Neuropharmacol. 15:669–671.CrossRefGoogle Scholar
  39. MENZIE, G. M., 1971, Apomorphine-induced aggression in the rat, Brain Res. 34:323–330.CrossRefGoogle Scholar
  40. MENZIE, G. M., 1972, Role of the tuberculum olfactorium in stereotyped behavior induced by apomorphine in the rat, Psychopharmacologia 23:212–219.CrossRefGoogle Scholar
  41. MURPURGO, C., and THEOBALD, W., 1966, Behavioral reactions to amphetamine in reserpinized rats, J. Neuropharmacol. 5:375–377.CrossRefGoogle Scholar
  42. NIEMEGEERS, C.J. E., and JANSSEN, P. A. J., 1974, Promoperidol, a new potent neuroleptic of the butryrophenone series, Arzneim. Forsch. 24:45–52.Google Scholar
  43. NIEMEGEERS, C.J. E., and JANSSEN, P. A. J., 1975, Differential antagonism to amphetamine-induced oxygen consumption and agitation by psychoactive drugs, in: Antidepressants (S. Fielding and H. Lal, eds.), pp. 125–141, Futura Publishing, Mount Kisco, New York.Google Scholar
  44. NIEMEGEERS, D. J. E., VERBRUGGEN, F. J., and JANSSEN, P. A. J., 1969a, The influence of various neuroleptic drugs on shock avoidance responding in rats. I. Nondiscriminated Sidman avoidance procedure, Psychopharmacologia (Berlin) 16:161–174.CrossRefGoogle Scholar
  45. NIEMEGEERS, C. J. E., VERBRUGGEN, F. J., and JANSSEN, P. A. J., 1969b, The influence of various neuroleptic drugs of shock avoidance responding in rats. II. Nondiscriminated Sidman avoidance procedure with alternate reinforcement and extinction periods and analysis of the inter-response times (IRT’s) (1), Psychopharmacologia (Berlin) 16:175–182.CrossRefGoogle Scholar
  46. OLDS, M. E., 1972, Alterations by centrally acting drugs of the suppression of self-stimulation behavior in the rat by tetrabenazine, physostigmine, chlorpromazine and pentobarbital, Psychopharmacology 25:299–314.CrossRefGoogle Scholar
  47. OLTSMAN, G. A., and HARVEY, J. A., 1972, “LH syndrome” and brain catecholamine levels after lesions of the nigro-striatal bundle, Physiol. Behav. 8:69–78.CrossRefGoogle Scholar
  48. PFEIFFER, C. C., and JENNY, E. H., 1957, The inhibition of the conditioned response and the counteraction of schizophrenia by muscarinic stimulation of the brain, Ann. N.Y. Acad. Sci. 66:753–764.PubMedCrossRefGoogle Scholar
  49. PLETSCHER, A., GEY, K. F., and BURKARD, W. P., 1967, Effect of neuroleptics on the cerebral metabolism of catecholamines, “Toxicity and Side Effects of Psychotropic Drugs,” Excerpta Med. Int. Congr. Ser. 145:98–106.Google Scholar
  50. POZUELO, J., and KERR, F. W. L., 1972, Suppression of craving and other signs of dependence in monkeys by administration of alpha-methyl-paratyrasine, Mayo Clinic Proc. 47:621–628.Google Scholar
  51. PURI, S. K., and LAL, H., 1973a, Effect of dopaminergic stimulation or blockade on morphine withdrawal aggression, Psychopharmacologia 32:113–118.PubMedCrossRefGoogle Scholar
  52. PURI, S. K., and LAL, H., 1973b, Effect of apomorphine benztropine or morphine on striatal dopamine turnover: Evidence for latent supersensitivity of dopaminergic receptors in morphine dependent rats, Pharmacologist 15:247.Google Scholar
  53. PURI, S. K., and LAL, H., 1974, Reduced threshold to pain-induced aggression specifically related to morphine dependence, Psychopharmacologia 35:237–242.PubMedCrossRefGoogle Scholar
  54. SCHAUMANN, W., and KURBJUWEIT, J.-G., 1961, Beeinflussung verscheidener Wirkurgen von Thiopropazat durch ein zentrales Stimulans, Arzneim. Forsch. 11:343–350.Google Scholar
  55. SEEVERS, M. H., and DENEAU, G. A., 1963, Physiological aspects of tolerance and physical dependence, in: Physiological Pharmacology, Vol. 1, (W. Root and F. Hofmann, eds.), pp. 565–640, Academic Press, New York.Google Scholar
  56. SENAULT, B., 1970, Comportement d’aggressivité intraspeciflque induit par l’apomorphine chez le rat, Psychopharmacologia 18:271–287.PubMedCrossRefGoogle Scholar
  57. SENAULT, B., 1972, Effets de lesions du septum, de l’amygdale, du striatum, de la substantia nigra et de l’ablation des bulbes olfactifs sur le comportement d’aggressivité intraspeciflque induit par l’apomorphine chez le rat, Psychopharmacologia 24:476–484.PubMedCrossRefGoogle Scholar
  58. SENAULT, B., 1974, Amines cérébrales et comportement d’aggressivité intraspeciflque induit par l’apomorphine chez le rat, Psychopharmacologia 34:143–154.PubMedCrossRefGoogle Scholar
  59. SINGH, J., 1973, Model to study methadone addiction, Pharmacologist 15:242.Google Scholar
  60. SINGH, M. M., and KAY, S. R., 1975, Therapeutic reversal with benztropine in schizophrenics—Practical and therapeutic significance, J. Nerv. Ment. Dis. 119:258–266.Google Scholar
  61. SINGH, M. M., and KAY, S. R., 1976, Cholinergic processes in schizophrenia, J. Psychosynth. 8:34–41.Google Scholar
  62. SINGH, M., and LAL, H., 1973, The problem of narcotic addiction: Innovative approaches for study and treatment, J. Bronx State Hosp. 1:127–136.Google Scholar
  63. SINGH, M. M., and SMITH, I. M., 1971, Reversal of some therapeutic effects of haloperidol by anti-parkinson drugs, Pharmacologist 13:287.Google Scholar
  64. STAWARZ, R. J., HILL, H., ROBINSON, P., SETLER, J. V., and SULSER, F., 1975, On the significance of the increase in homovanillic acid (HVA) caused by antipsychotic drugs in corpus striatum and limbic forebrain, Psychopharmacologia 43:125–130.PubMedCrossRefGoogle Scholar
  65. TAESCHLER, M., WEIDMANN, H., and CERLETTI, A., 1962, Zur Pharmakologie von Ponalid, einem neuen zentralen, Anticholinergicum, Schweiz. Med. Wochenschr. 92:1542–1545.PubMedGoogle Scholar
  66. TEDESCHI, R. E., TEDESCHI, D. H., MUCHA, A., COOK, L., MATTIS, P. A., and FELLOWS, E. J., 1959, Effects of various centrally acting drugs on fighting behavior of mice, J. Pharmacol. Exp. Ther. 125:28–24.PubMedGoogle Scholar
  67. THOR, D. H., 1969, Chemical induction of traumatic fighting behavior, Proc. Am. Psychol. Assoc. 4:883–884.Google Scholar
  68. THOR, D. H., HOATS, D. L., and THOR, C. J., 1970, Morphine induced fighting and prior social experience, Psychon. Sci. 18:137–139.Google Scholar
  69. ULRICH, R., and AZRIN, N. H., 1962, Reflexive fighting in response to aversive stimulation, J. Exp. Anal. Behav. 5:511–520.PubMedCrossRefGoogle Scholar
  70. UNGERSTEDT, U., 1970, Is interruption of the nigro-striatal dopamine system producing the “lateral hypothalamic syndrome”? Acta Physiol. Scand. 80:35A-36A.PubMedCrossRefGoogle Scholar
  71. UNGERSTEDT, U., 1971a, Adipsia and aphagia after 6-hydroxy dopamine induced degeneration of the nigro-striatal dopamine system, Acta Physiol. Scand. Suppl., 367:95–122.PubMedGoogle Scholar
  72. UNGERSTEDT, U., 1971b, Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behavior, Acta Physiol. Scand. 82(Suppl. 367):49–68.Google Scholar
  73. VALZELLI, L., 1967, Drugs and aggressiveness, Adv. Pharmacol. 5:79–108.PubMedCrossRefGoogle Scholar
  74. VALZELLI, L., 1970, The “isolation syndrome” in mice, Psychopharmacologia 31:305–320.CrossRefGoogle Scholar
  75. WAUQUIER, A., NIEMEGEERS, C. J. E., and LAL, H., 1975, Differential antagonism by the anticholinergic dexetimide of inhibitory effects of haloperidol and fentanyl on brain self-stimulation, Psychopharmacologia 41:229–235.PubMedCrossRefGoogle Scholar
  76. WEISSMAN, A., 1973, Jumping in mice elicited by a-naphthyloxyacetic acid, J. Pharmacol. Exp. Ther. 184:11–17.PubMedGoogle Scholar
  77. WELCH, B. L., and WELCH, A. S., 1970, Some aspects of brain biochemistry correlated with general nervous reactivity and aggressiveness, in: Animal Aggression: Selected Readings (C. H. Southwick, ed.), pp. 187–200, Van Nostrand-Reinhold, New York.Google Scholar
  78. YEN, C. Y., STRANGER, R. L., and MILLMAN, N., 1959, Ataractic suppression of isolation induced aggressive behavior, Arch. Int. Pharmacodyn. 123:179–185.PubMedGoogle Scholar
  79. ZIS, A. P., and FIBIGER, H. C., 1975, Neuroleptic-induced deficits in food and water regulation: Similarities to the lateral hypothalamic syndrome, Psychopharmacologia 43:63–68.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Stuart Fielding
    • 1
  • Harbans Lal
    • 2
  1. 1.Hoechst-Roussel Pharmaceuticals Inc.SomervilleUSA
  2. 2.Departments of Pharmacology and PsychologyUniversity of Rhode IslandKingstonUSA

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