Classification and Location of Neurons Taking Up 3H-GABA in the Visual Cortex of Rats
There is converging evidence from biochemical and electrophysiological work suggesting that GABA acts as an inhibitory transmitter in the neocortex (Baxter, 1970; Krnjević, 1976). However, except for the reports of Hökfelt and Ljungdahl (1971/ 1972), suggesting that neurons in lamina I (LI) to LIII take up 3H -GABA, little is known of the type and position of neurons which might take up, produce and utilize GABA. This preliminary report presents an autoradiographic study of the distribution of neurons taking up 3H-GABA and their location in various layers of the adult rat neocortex.
KeywordsVisual Cortex Subcortical White Matter Label Neuron Cortical Plate Inhibitory Transmitter
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- Baxter, C.F., 1970, The nature of γ-aminobutyric acid, in “Handbook of Neurochemistry,” Vol. 3 (A. Lajtha, ed.), pp. 289–253, Plenum Press, New York - London.Google Scholar
- Colonnier, M.L., 1966, The structural design of the neocortex, in “Brain and Conscious Experience,” (J.C. Eccles, ed.), pp. 1–23, Springer-Verlag, Berlin-Heidelberg-New York.Google Scholar
- Hökfelt, T., and Ljungdahl, Å., 1972, Autoradiographic identification of cerebral and cerebellar cortical neurons accumulating labeled gairma-aminobutyric acid (3H-GABA), Exp. Brain Res. 14: 354–362.Google Scholar
- Krnjević, K., 1976, Inhibitory action of GABA and GABA-mimetics on vertebrate neurons, in “GABA in Nervous System Function” ( E. Roberts, T.N. Chase, and D.B. Tower, eds.), pp. 269–281, Raven Press, New York.Google Scholar
- Rickmann, M., Chronwall, B.M., and Wolff, J.R., in press, On the development of non-pyramidal neurons and axons outside the cortical plate: The early marginal zone as a pallial anlage.Google Scholar
- Szentágothai, J., 1973, Synaptology of the visual cortex, in “Handbook of Sensory Physiology,” Vol. VII/3 (R. Jung, ed.), pp. 270–321, Springer-Verlag, Berlin-Heidelberg-New York.Google Scholar
- Szentágothai, J., 1976, Basic circuitry of the neocortex, Exp. Brain Res. Suppl. 1: 282–287.Google Scholar