Advertisement

Classification and Location of Neurons Taking Up 3H-GABA in the Visual Cortex of Rats

  • B. M. Chronwall
  • J. R. Wolff
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 16)

Abstract

There is converging evidence from biochemical and electrophysiological work suggesting that GABA acts as an inhibitory transmitter in the neocortex (Baxter, 1970; Krnjević, 1976). However, except for the reports of Hökfelt and Ljungdahl (1971/ 1972), suggesting that neurons in lamina I (LI) to LIII take up 3H -GABA, little is known of the type and position of neurons which might take up, produce and utilize GABA. This preliminary report presents an autoradiographic study of the distribution of neurons taking up 3H-GABA and their location in various layers of the adult rat neocortex.

Keywords

Visual Cortex Subcortical White Matter Label Neuron Cortical Plate Inhibitory Transmitter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Baxter, C.F., 1970, The nature of γ-aminobutyric acid, in “Handbook of Neurochemistry,” Vol. 3 (A. Lajtha, ed.), pp. 289–253, Plenum Press, New York - London.Google Scholar
  2. Colonnier, M.L., 1966, The structural design of the neocortex, in “Brain and Conscious Experience,” (J.C. Eccles, ed.), pp. 1–23, Springer-Verlag, Berlin-Heidelberg-New York.Google Scholar
  3. Hökfelt, T., and Ljungdahl, Å., 1971, Uptake of [3H]noradrenalin and γ-[3H] aminobutyric acid in isolated tissue of rat: An autoradiographic and fluorescent microscopic study, Prog. Brain Res. 34: 87–102.CrossRefGoogle Scholar
  4. Hökfelt, T., and Ljungdahl, Å., 1972, Autoradiographic identification of cerebral and cerebellar cortical neurons accumulating labeled gairma-aminobutyric acid (3H-GABA), Exp. Brain Res. 14: 354–362.Google Scholar
  5. Iversen, L.L., and Bloom, F.E., 1972, Studies of the uptake of 3H-GARA and 3H glycine in slices and homogenates of rat brain and spinal cord by electron microscopic autoradiography, Brain Res. 41: 131–143.PubMedCrossRefGoogle Scholar
  6. Kelly, J.P., and Van Essen, D.C., 1974, Cell structure and function in the visual cortex of the cat, J. Physiol. 238: 515–547.PubMedGoogle Scholar
  7. Krnjević, K., 1976, Inhibitory action of GABA and GABA-mimetics on vertebrate neurons, in “GABA in Nervous System Function” ( E. Roberts, T.N. Chase, and D.B. Tower, eds.), pp. 269–281, Raven Press, New York.Google Scholar
  8. Neal, M.J., and Iversen, L.L., 1969, Subcellular distribution of endogenous and [3H] γ-aminobutyric acid in rat cerebral cortex, J. Neurochem. 15: 1245–1252.CrossRefGoogle Scholar
  9. Rickmann, M., Chronwall, B.M., and Wolff, J.R., in press, On the development of non-pyramidal neurons and axons outside the cortical plate: The early marginal zone as a pallial anlage.Google Scholar
  10. Szentágothai, J., 1973, Synaptology of the visual cortex, in “Handbook of Sensory Physiology,” Vol. VII/3 (R. Jung, ed.), pp. 270–321, Springer-Verlag, Berlin-Heidelberg-New York.Google Scholar
  11. Szentágothai, J., 1976, Basic circuitry of the neocortex, Exp. Brain Res. Suppl. 1: 282–287.Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • B. M. Chronwall
    • 1
  • J. R. Wolff
    • 1
  1. 1.Dept. Neurobiology, NeuroanatomyMax-Planck-Institute for Biophysical ChemistryGöttingenGermany

Personalised recommendations