Abstract
In September 1953 three young men sat on the grass on the grounds of the Allan Memorial Institute of Psychiatry, McGill University, in Montreal, Canada. The Allan Institute is situated on the slopes of Mount Royal (Fig. 1) and the view of the city below was spectacularly beautiful (Fig. 2). September and October are the best months in Montreal, with unexpected warmth, clear skies, and brilliant colors in the trees. But the young men were not looking at the scenery; they were planning experiments.
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Chan, L. T., de Wied, D., and Saffran, M. (1969a). Comparison of assays for corticotrophin- releasing activity. Endocrinology 84:967.
Chan, L. T., Schaal, S. M., and Saffran, M. (19696). Properties of the corticotrophin-releasing factor of the rat median eminence. Endocrinology 85:644.
Cleghorn, R. A., Graham, B. F., Saffran, M., and Cameron, D. E. (1950). A study of the effect of the pituitary ACTH in depressed patients. Can. Med. Assoc. J. 63:329.
Fields, W. S., Guillemin, R., and Carlton, C. A. (eds.) (1956). Hypothalamic-hypophysial Interrelationships, Thomas, Springfield, Ill.
Hokin, M. R., Hokin, L. E., Saffran, M., Schally, A. V., and Zimmermann, B. U. (1958). Phospholipides and the secretion of adrenocorticotropin and of corticosteroids.Biol. Chem. 233:811.
Pearlmutter, A. F., Rapino, E., and Saffran, M. (1975). The ACTH-releasing hormone of the hypothalamus requires a co-factor. Endocrinology 97:1336.
Preddie, E. C., and Saffran, M. (1965a). Isolation of a large polypeptide from bovine posterior pituitary powder. J. Biol. Chem. 240:4189.
Preddie, E. C., and Saffran, M. (1965b). Structure of a large polypeptide of bovine posterior pituitary tissue. Biol. Chem. 240:4194.
Saffran, M., and Bayliss, M. J. (1953). In vitro bioassay of corticotrophin. Endocrinology 52:140.
Saffran, M., and Denstedt, O. F. (1951). The effect of intravenously injected citrate on the serum ionized calcium in the rabbit. Can. J. Med. Sci. 29:245.
Saffran, M., and Prado, J. L. (1949). Inhibition of aconitase by transaconitate. J. Biol. Chem. 180:1301.
Saffran, M., and Schally, A. V. (1955a). In vitro bioassay of corticotrophin; modification and statistical treatment. Endocrinology 56:523.
Saffran, M., and Schally, A. V. (1955b). The release of corticotrophin by anterior pituitary tissue in vitro. Can. J. Biochem. Physiol. 33:408.
Saffran, M., and Schally, A. V. (1958). An in vitro system for the study of the neural control of ACTH secretion Curri, A. B., and Martini, L. (eds.), Pathophysiologia Diencephalica, Springer, Vienna, p. 780.
Saffran, M., Grad, B., and Bayliss, M. J. (1952). Production of corticoids by rat adrenals in vitro. Endocrinology 50:639.
Saffran, M., Schally, A. V., and Benfey, B. G. (1955). Stimulation of the release of corticotrophin from the adenohypophysis by a neurohypophysial factor. Endocrinology 57:439.
Saffran, M., Caplan, B. U., Mishkin, S., and Muhlstock, B. (1962). Use of percolation for the extraction of vasopressin. Endocrinology 70:43.
Saffran, M., Ford, P., Matthews, E. K., Kraml, M., and Garbaczewska, L. (1967). An automated method for following the production of corticosteroids by adrenal tissue in vitro. Can. J. Biochem. 45:1901.
Saffran, M., Pearlmutter, A. F., Rapino, E., and Upton, G. V. (1972). Pressinoic acid: A peptide with potent corticotrophin-releasing activity. Biochem. Biophys. Res. Commun. 49:748.
Saffran, M., Pearlmutter, A. F., and Rapino, E. (1973). In vitro assays for corticotrophin- releasing factors. In Brodish, A., and Redgate, E. S. (eds.), Brain Pituitary Adrenal Interrelationships, Karger, New York, p. 47.
Schally, A. V., Saffran, M., and Zimmerman, B. (1958). A corticotrophin- releasing factor: Partial purification and amino acid composition. Biochem. J. 70:97.
Schonbaum, E., Birmingham, M. K., and Saffran, M. (1956). Metabolism of glucose and steroid formation by rat adrenals in vitro. Can. J. Biochem. Physiol. 34:527.
Shome, B., and Saffran, M. (1966). Peptides of the hypothalamus. J. Neurochem. 13:433.
Wuu, T. C., and Saffran, M. (1969). Isolation and characterization of a hormone binding polypeptide from pig posterior pituitary powder. J. Biol. Chem. 244:482
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© 1978 Plenum Press, New York
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Saffran, M. (1978). Corticotropin-Releasing Factor: The Elusive Hormone. In: Meites, J., Donovan, B.T., McCann, S.M. (eds) Pioneers in Neuroendocrinology II. Perspectives in Neuroendocrine Research, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4027-0_20
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DOI: https://doi.org/10.1007/978-1-4613-4027-0_20
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