Abstract
The malignant lymphomas are now acknowledged to be neoplasms of the immune system. The traditional terminology and classifications of the past, including the clinically useful classification of Rappaport (Rappaport et al., 1956), were proposed before the recent dramatic developments in immunology and therefore have no relationship to our modem understanding of immunology. Beginning in 1971, we proposed a conceptually new approach to the understanding of malignant lymphomas (Collins and Lukes, 1971; Lukes and Collins, 1973, 1974a,b). This approach was based on (1) the newly appreciated existence of the T- and B-lymphocytic systems; (2) our hypothesis that lymphomas may arise from aberrations in lymphocyte transformation; and (3) the availability of techniques to identify cells as belonging to the T- or the B-lymphocytic system. In this approach, lymphoma cells are regarded as immune cells that, although defective, function, migrate, “home” to, and reside in tissue sites in ways similar to their normal counterparts. Fundamental to our new functional approach is the follicular center cell (FCC) concept, which has the following bases: (1) FCC are plasma-cell precursors; (2) the follicular center is a site of B-cell transformation; (3) lymphomas of FCC type are observed with both follicular and diffuse histological patterns; and (4) these lymphomas are a group of different cytological types, rather than one lymphoma of follicular structures, previously termed “follicular lymphoma.”
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Abbreviations
- Abbreviations used in this chapter:
-
(ALL) Acute lymphocytic leukemia
- CLL:
-
(CLL) chronic lymphocytic leukemia
- (EA) erythrocyte:
-
antibody complex
- (EAC) erythrocyte:
-
antibody-complement complex
- FCC:
-
(FCC) follicular center cell(s)
- (HBLA) human B:
-
lymphocyte antigen
- H chain:
-
(H chain) heavy chain
- (HTLA) human T:
-
lymphocyte antigen
- IBL:
-
(IBL) immunoblastic lymphadenopathy
- IBS:
-
(IBS) immunoblastic sarcoma
- Ig:
-
(Ig) immunoglobulin
- L chain:
-
(L chain) light chain
- (MGP) methyl green:
-
pyronin stain
- (MLR) mixed:
-
lymphocyte reaction
- NSE:
-
(NSE) nonspecific esterase
- (PAS) periodic acid:
-
Schiff stain
- PHA:
-
(PHA) phytohemagglutinin
- PWM:
-
(PWM) pokeweed mitogen
- SIg:
-
(SIg) surface Ig
- SLE:
-
(SLE) systemic lupus erythematosus
- SRBC:
-
(SRBC) sheep erythrocyte(s)
- U cell:
-
(U cell) undefined cell.
References
Aisenberg, A. C., and Long, J. C., 1975, Lymphocyte surface characteristics in malignant lymphoma. Am. J. Med. 58: 300–306.
Anagnostou, D., Parker, J. W., Taylor, C. R., Tindle, B. H., and Lukes, R. J., 1977, Lacunar cells of nodular sclerosing Hodgkin’s disease: An ultrastructural and immunohistologic study, Cancer 39: 1032–1043.
Bain, B., Vas, M. R., and Lowenstein, L., 1964, The development of large immature mononuclear cells in mixed lymphocyte cultures. Blood 23: 108–116.
Barcos, M. P., and Lukes, R. J., 1975, Malignant lymphoma of convoluted lymphocytes: A new entity of possible T-cell type, in: Conflicts in Childhood Cancer ( L. F. Sinks, and J. O. Godden, eds.), pp. 147–178, Alan R. Liss, New York.
Bennett, M. H., and Millet, Y. L., 1969, Nodular sclerotic lymphosarcoma: A possible new clinico-pathological entity, Clin. Radiol. 20: 339–343.
Bennett, M. H., Farrer-Brown, G., Henry, K., and Jelliffe, A. M., 1974, Classification of non-Hodgkin’s lymphomas. Lancet 2: 405.
Berard, C., O’Connor, G. T., Thomas, L. B., and Torloni, H., 1969, Histopathologic definition of Burkitt’s tumour. Bull. W. H. O. 40: 601–607.
Berard, C. W., Gallo, R. C., Jaffe, E., Green, I., and Devita, V. T., 1976, Current concepts of leukemia and lymphoma: Etiology, pathogenesis and therapy, Ann. Intern. Med. 85: 351–366.
Berger, N. A., and Skinner, A. M., 1974, Characterization of lymphocyte transformation induced by zinc ions, J. Cell Biol. 61: 45–55.
Bhattacharyza, J. R., 1975, Terminal deoxyribonucleotidyl transferase in human leukemia, Biochem. Biophys. Res. Commun. 62: 367.
Boldt, D. H., Speckart, S. R., MacDermott, R. P., Nash, G. S., and Valeski, J. E., 1977, Leukemic reticuloendotheliosis: “Hairy cell leukemia,” functional and structural features of the abnormal cell in a patient with profound leukocytosis, Blood 49: 745–757.
Braylan, R. C., Jaffe, E. S., and Berard, C. W., 1975, Malignant lymphomas: Current classifications and new observations, in: Pathology Annual, Vol. 10 ( S. C. Sommers, ed.), pp. 213–270, Appleton- Century-Crofts, New York.
Brochier, J., Bona, C., Ciorbaru, R., Revillard, J. P., and Chedid, L., 1976, A human T-independent B lymphocyte mitogen extracted from Nocardia opaca, J. Immunol. 117: 1434–1439.
Broder, S., Edelson, R. L., Lutzner, M. A., Nelson, D. L., MacDermott, R. P., Durm, M. E., Goldman, C. K., Meade, B. D., and Waldmann, T. A., 1976, The Sézary syndrome-A malignant proliferation of helper T cells, J. Clin. Invest. 58: 1297–1306.
Brouet, J., LaBaume, S., and Seligmann, M., 1975, Evaluation of T and B lymphocyte membrane markers in human non-Hodgkin’s malignant lymphomas, Br. J. Cancer 31 (SuppL 2): 121–127.
Caron, G. A., Poutala, S., and Provost, T. T., 1970, Lymphocyte transformation induced by inorganic and organic mercury, Int. Arch. Allergy Appl. Immunol. 37: 76–87.
Catovsky, D., Galetto, J., Okos, A., Milliani, E., and Galton, D. A. G., 1974, Cytochemical profile of B and T leukaemic lymphocytes with special reference to acute lymphoblastic leukaemia, J. Clin. Pathol. 27: 767–771.
Collins, R. D., and Lukes, R. J., 1971, Studies on possible derivation of some malignant lymphomas from follicular center cells. Am. J. Pathol. 62: 63a.
Davey, F, R., Goldberg, J., Stockman, J., and Gottlieb, A. J., 1976, Immunologic and cytochemical cell markers in non-Hodgkin’s lymphomas. Lab. Invest. 35: 430–438.
Dorfman, R. F., 1974, Classification of non-Hodgkin’s lymphomas, Lancet 1: 1295.
Dutcher, T. F., and Fahey, J. L., 1959, The histopathology of the macroglobulinemia of Waldenström, J. Natl. Cancer Inst. 22: 887–916.
Gajl-Peczalska, K. J., Bloomfield, C. D., Coccia, P. F., Sosin, H., Brunning, R. D., and Kersey, J. H., 1975, B and T cell lymphomas, Am. J. Med. 59: 674–685.
Gall, E. A., 1958, The reticulum cell: The cytological identity and interrelation of mesenchymal cells of lymphoid tissue, Ann. N.Y. Acad. Sci. 73: 120–130.
Gerard-Merchant, R., Hamlin, I., Lennert, K., Rilke, F., Stansfeld, A. G., and Van Unnik, J. A. M., 1974, Classification of non-Hodgkin’s lymphomas, Lancet 2: 406.
Good, R. A., and Finstad, J., 1968, The association of lymphoid malignancy and immunologic functions, in: Proceedings of the International Conference on Leukemia-Lymphoma ( C. J. D. Zarafonetis, ed.), pp. 175–197, Lea & Febiger, Philadelphia.
Gordon, I. L., Lukes, R. J., O’Brien, R. L., Parker, J. W., Rembaum, A., Russell, R., and Taylor, C. R., 1977, Visualization of surface immunoglobulin of human B lymphocytes using microsphere-immunoglobulin conjugates in Giemsa stained preparations, Clin. Immunol. Immunopathol. 8: 51–63.
Graham, R. C., Jr., and Kamovsky, M. J., 1966, The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: Ultrastructural cytochemistry by a new technique, J. Histochem. Cytochem. 14: 291–302.
Green, I., Jaffe, E., Shevach, E. M., Edelson, R. L., Frank, M. M., and Berard, C. W., 1975, Determination of the origin of malignant reticular cells by the use of surface membrane markers, in: The Reticuloendothelial System, International Academy of Pathology Monograph No. 16 ( J. W. Rebuck, C. W. Berard, and M. R. Abell, eds.), pp. 282–300, Williams and Wilkins Co., Baltimore.
Hansen, J. A., and Good, R. A., 1974, Malignant disease of the lymphoid system in immunologic perspective. Hum. Pathol. 5: 567–599.
Hovi, T., Allison, A. C., and Williams, S. C., 1976, Proliferation of human peripheral blood lymphocytes induced by A23187, a Streptomyces antibiotic, Exp. Cell Res. 97: 92–100.
Hungerford, D. A., Donnelly, A. J., Nowell, P. C., and Beck, S., 1959, The chromosome constitution of a human phenotypic intersex. Am. J. Hum. Genet. 11: 215–236.
Hutton, J. J., and Coleman, M. S., 1975, Terminal deoxyribonucleotidyl transferase in adult leukemia. Blood 46: 1043.
Jondal, M., Holm, G., and Wigzell, H., 1972, Surface markers on human T and B lymphocytes, J. Exp. Med. 136: 207–215.
Jones, S. E., Fuks, Z., Bull, M., Kadin, M., Dorfman, R. F., Kaplan, H. S., Rosenberg, S. A., and Kim, H., 1973, Non-Hodgkin’s lymphomas. IV. Clinico-pathologic correlation in 405 cases. Cancer 32: 682–691.
Kaplan, J. G., and Bona, C., 1974, Proteases as mitogens: The effect of trypsin and pronase on mouse and human lymphocytes, Exp. Cell Res. 88: 388–394.
Kaplan, J., Ravindranath, Y., and Peterson, W. D., 1977, Lymphocyte antigen-positive null cell leukemias. Blood 49: 371–378.
Kojima, M., and Tsunoda, R., 1976, Localization of immunoglobulins in germinal centers of human tonsils, in: The Reticuloendothelial System in Health and Disease: Immunologic and Pathologic Aspects ( H. Friedman, ed.), pp. 77–86, Plenum Publishing Corp., New York.
Kunkel, H. G., 1975, Surface markers of human lymphocytes, Johns Hopkins Med. J. 137: 216–223.
Leech, J., Glick, A., Horn, R., and Collins, R., 1975, Immunologic, histochemical and ultrastructural studies of malignant lymphomas presumed to be of follicular center cell origin, J. Natl. Cancer Inst. 54: 11–21.
Lennert, K., and Mestdagh, J., 1968, Lymphogranulomatosen mit konstant hohem Epitheloidzellgehalt, Virchows Arch. Pathol. Anat. Physiol. 344: 1–20.
Lennert, K., Mohri, N., Stein, H., and Kaiserling, E., 1975, The histopathology of malignant lymphomas, Br. J. Haematol. 31 (Suppl. 2): 193–203.
Lillie, R. D., and Fullmer, H. M., 1976, Histopathologic Technic and Practical Histochemistry, 4th Ed., pp. 52–53, McGraw-Hill, New York.
Long, J. C., and Aisenberg, A. C., 1975, Richter’s syndrome: A terminal complication of chronic lymphocytic leukemia with distinct clinicopathologic features. Am. J. Clin. Pathol. 63: 786–795.
Lukes, R. J., 1968, The pathological picture of the malignant lymphomas, in: Proceedings of the International Conference on Leukemia-Lymphoma ( C. J. D. Zarafonetis, ed.), pp. 333–356, Lea & Febiger, Philadelphia.
Lukes, R. J., 1971, Criteria for involvement of lymph node, bone marrow, spleen and liver in Hodgkin’s disease. Cancer Res. 31: 1755–1767.
Lukes, R. J., and Collins, R. D., 1973, New observations on follicular lymphoma, in: Gann Monogr. Cancer Res. 15: Malignant Diseases of the Hematopoietic System (K. Akazaki et al, eds,), pp. 209–215, University Park Press, Baltimore-London-Tokyo.
Lukes, R. J., and Collins, R. D., 1974a, Immunologic characterization of human malignant lymphomas. Cancer 34: 1488–1503.
Lukes, R. J., and Collins, R. D., 1974b, A functional approach to the classification of malignant lymphoma. Recent Results Cancer Res. 46: 18–30.
Lukes, R. J., and Collins, R. D., 1975, New approaches to the classification of the lymphomata, Br. J. Cancer 31 (Suppl. 2): 1–28.
Lukes, R. J., and Collins, R. D., 1977, The Lukes-Collins classification and its significance. Conference on the Non-Hodgkin’s Lymphomas, San Francisco, September 30–0ctober 2, 1976, in: Cancer Treatment Rep. 61: 971–979.
Lukes, R. J., and Tindle, B. H., 1975, Immunoblastic lymphadenopathy: A hyperimmune entity resembling Hodgkin’s disease, N. Engl. J. Med. 292: 1–8.
Lukes, R. J., Craver, L. L., Hall, T. C., Rappaport, H., and Ruben, P., 1966a, Hodgkin’s disease: Report of Nomenclature Committee, Cancer Res. 26: 1311.
Lukes, R. J., Butler, J. J., and Hicks, E. B., 1966b, Natural history of Hodgkin’s disease as related to its pathologic picture. Cancer 19: 317–344.
Lukes, R. J., Tindle, B. H., and Parker, J. W., 1969, Reed-Stemberg-like cells in infectious mononucleosis, Lancet 2: 1003–1004.
Lutzner, M., Edelson, R., Schein, P., Green, I., Kirkpatrick, C., and Ahmed, A., 1975, Cutaneous T cell lymphoma: The Sezary syndrome, mycosis fungoides and related disorders, Ann. Intern. Med. 85: 534–552.
Maino, V. C., Green, N. M., and Crumpton, M. J., 1974, The role of calcium ions in initiating transformation of lymphocytes. Nature (London) 251: 324–327.
Mann, R. B., Jaffe, E. S., Braylan, R. C., Nanba, K., Frank, M. M., Ziegler, J. L., and Berard, C. W., 1976, Non-endemic Burkitt’s lymphoma: A B-cell tumor related to germinal centers, N. Engl. J. Med. 295: 685–691.
Mason, D. Y., and Taylor, C. R., 1975, The distribution of muramidase (lysozyme) in human tissues, J. Clin. Pathol. 28: 124.
McCaffrey, A., Smoler, D. F., and Baltimore, D., 1973, Terminal deoxynucleotidyl transferases in a case of childhood acute lymphoblastic leukaemia, Proc. Nad. Acad. Sci. U.S.A. 70: 521–525.
Nossal, G. J. V.. Abbot, A., Mitchell, J., and Lummus, Z., 1968, Antigens in immunity. XV. Ultrastructural features of antigen capture in primary and secondary lymphoid follicles, J. Exp. Med. 127: 277–289.
Nowell, P. C., 1960, Phytohemagglutinin: An initiator of mitosis in cultures of normal human leukocytes, Cancer Res. 20: 462–466.
O’Brien, R. L., and Parker, J. W., 1976, Oxidation-induced lymphocyte transformation: A review. Cell 7: 13–20.
O’Brien, R. L., Parker, J. W., and Dixon, J. F. P., 1978, Mechanisms of lymphocyte transformation, in: Progress in Molecular and Subcellular Biology, Vol. 6 (F. Hahn, ed.). Springer-Verlag, Berlin-Heidelberg-New York (in press).
Ohnuma, T., Orlowski, M., Minowada, J., and Holland, J. F., 1976, Differences in amino acid metabolism of human T- and B-cells in culture, presented at the Proceedings of the 16th Interna-tional Congress of Hematology, Kyoto, Japan, September 5–11, 1976.
Oppenheim, J. J., and Rosenstreich, D. L., 1976, Signals regulating in vitro activation of lymphocytes, Prog. Allergy 20: 65–194.
Order, S. E., and Hellman, S., 1972, Pathogenesis of Hodgkin’s disease, Lancet l;571–573.
Parker, J. W., Steiner, J., Coffin, A., Lukes, R. J., Burr, K., and Brilliantine, L., 1969, Blastomitogenic agents in Leguminosae and other families, Experientia 25: 187–188.
Parker, J. W., Royston, A. I., Pattengale, P., Taylor, C. R., Tindle, B. H., Cain, M. J., and Lukes, R. J., 1978, Morphological differences between cultured human B and T lymphoblastoid cell lines: A light and electron microscopic and cytochemical study, J. Natl. Cancer Inst. 60(in press).
Pearmain, G., Lycette, R. R., and Fitzgerald, P. H., 1963, Tuberculin-induced mitosis in peripheral blood leucocytes. Lancet 1: 637–638.
Preud’homme, J. L., and Seligmann, M., 1974, Surface immunoglobulins on human lymphoid cells. Prog. Clin. Immunol. 2: 121–174.
Rappaport, R., Winter, W. J., and Hicks, E. B., 1956, Follicular lymphoma: Re-evaluation of its position in the scheme of malignant lymphoma, based on survey of 253 cases. Cancer 9: 792–821.
Riccardi, A., Piazza, R., and Perugini, S., 1976, Deoxyribonucleic acid content of cleaved and non- cleaved cells in follicular center cell lymphomas: A cytofluorometric study, Haematologica 61: 170–183.
Richter, M. N., 1928, Generalized reticular cell sarcoma of lymph nodes associated with lymphatic leukemia. Am. J. Pathol. 4: 285–292.
Rosen, P. J., Feinstein, D. L, Bonorris, J. M., Parker, J. W., Pattengale, P. K., Tindle, B. H., and Lukes, R. J., 1975, Convoluted lymphocytic (T-cell) lymphoma: A distinct clinical-pathologic entity. Annual Meeting of the American Society of Hematology, Dallas, Texas, Dec. 8, 1975 (abstract).
Schlossman, S. F., Chess, L., Humphreys, R. E., and Strominger, J. L., 1976, Distribution of la-like molecules on the surface of normal and leukemic human cells, Proc. Natl. Acad. Sci. U.S.A. 73: 1288–1292.
Schneider, B. K., Higgins, G. R., Swanson, V., Isaacs, H., Tindle, B. H., and Lukes, R. J., 1978, Malignant lymphomas of childhood (submitted).
Schöpf, E., Schulz, K. H., and Grom, M., 1967, Transformationen und Mitosen von Lymphocyten in vitro durch Quecksilber (II)-chlorid, Naturwissenschaften 54: 568–569.
Stein, H., Peterson, N., Gaedicke, G., Lennert, K., and Landberg, C., 1976, Lymphoblastic lymphoma of convoluted or acid phosphatase type-A tumor of T precursor cells, Int. J. Cancer 17: 292–295.
Taylor, C. R., 1976a, An immunohistological study of follicular lymphoma, reticulum cell sarcoma and Hodgkin’s disease, Eur. J. Cancer 12: 61–75.
Taylor, C. R., 1976b, Hodgkin’s Disease and the Lymphomas, Annual Research Reviews (D. F. Horrobin, ed.), Eden Press, Montreal.
Taylor, C. R., and Mason, D. Y., 1974, The immunohistological detection of intracellular immunoglobulin in formalin-paraffin sections from multiple myeloma and related conditions using the immune-peroxidase technique, Clin. Exp. Immunol. 18: 417–429.
Taylor, C. R., Gordon, I. L., Rembaum, A., Russell, R., Parker, J. W., O’Brien, R. L., and Lukes, R. J., 1977, Human B lymphocytes in Giemsa stained preparations, J. Immunol. Methods 17: 81–89.
Tindle, B. H., Parker, J. W., and Lukes, R. J., 1972, “Reed-Sternberg cells” in infectious mononucleo-sis?, Am. J. Clin. Pathol. 58:607–617.
Toyoshima, S., Osawa, T., and Tonomura, A., 1970, Some properties of purified phytohemagglutinin from Lens culinaris seeds, Biochim. Biophys. Acta 21: 514–521.
Vischer, T. L., 1974, Stimulation of mouse B lymphocytes by trypsin, J. Immunol. 113: 58–62.
Waxdal, M. J., and Basham, T. Y., 1974, B and T-cell stimulatory activities of multiple mitogens from pokeweed. Nature (London) 251: 163–164.
Weinstein, Y., Chambers, D. A., Bourne, H. R., and Melmon, K. L., 1974, Cyclic GMP stimulates lymphocyte nucleic acid synthesis. Nature (London) 251: 352–353.
Weinstein, Y., Segal, S., and Melmon, K. L., 1975, Specific mitogenic activity of 8-Br-guanosine 3’,5’-monophosphate (Br-cyclic GMP) on B lymphocytes, J. Immunol. 115: 112–117.
Wolner, N., Lieberman, P., Exelby, P., Dongio, G., Burcheval, J., Fang, S., and Murphy, M. L., 1975, Non-Hodgkin’s lymphoma in children: Results of treatment with LSA-L protocol, Br. J. Cancer 31 (Suppl. 2): 337.
Yam, L. T., Li, C. Y., and Crosby, W. H., 1971a, Cytochemical identification of monocytes and granulocytes. Am. J. Clin. Pathol. 55: 283–290.
Yam, L. T., Li, C. Y., and Lam, K. W., 1971b, Tartrate resistant acid phosphatase isoenzyme in the reticulum cells of leukemic reticuloendotheliosis, N. Engl. J. Med. 284: 357–360.
Yeckley, J. A., Weston, W. L., Thome, G., and Kruger, G. G., 1975, Production of Sezary-like cells from normal human lymphocytes. Arch. Dermatol. 111: 29–32.
Yoshida, T., Edelson, R., Cohen, S., and Green I., 1975, Migration inhibitory activity in serum and cell supernatants in patients with Sézary syndrome, J. Immunol. 114: 915–918.
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Lukes, R.J., Parker, J.W. (1978). The Pathology of Lymphoreticular Neoplasms. In: Twomey, J.J., Good, R.A. (eds) The Immunopathology of Lymphoreticular Neoplasms. Comprehensive Immunology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4015-7_9
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