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Biology, Clinical Patterns, and Treatment of Multiple Myeloma and Related Plasma–Cell Dyscrasias

  • Mehdi Farhangi
  • Elliott F. Osserman
Part of the Comprehensive Immunology book series (COMIMUN, volume 4)

Abstract

The common denominator in ail plasma–cell dyscrasias (PCDs) is the inordinate expansion of differentiated B–cell clones (plasma cells) capable of synthesis and secretion of immunoglobulin (Ig) or its subunits. The structurally homogeneous secreted proteins can be demonstrated in the serum and urine of the overwhelming majority of patients. In only rare instances can no secreted product be demonstrated, and infrequently, two or more clones can be shown to occur simultaneously (see Section 4.1.10f).

Keywords

Multiple Myeloma Monoclonal Protein Cold Agglutinin Bence Jones Protein Myeloma Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • Mehdi Farhangi
    • 1
  • Elliott F. Osserman
    • 2
  1. 1.Department of MedicineUniversity of Missouri-ColumbiaColumbiaUSA
  2. 2.Department of MedicineCollege of Physicians and Surgeons, Columbia UniversityNew YorkUSA

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