Effects of Anesthesia on Breathing Pattern

  • H. Gautier
  • J. H. Gaudy
  • M. Bonora
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 99)


In recent years, it has been shown that in anesthetized cats an inverse relationship is observed between the tidal volume (VT) and the inspiratory duration (TI) when VT increases as a result of hypercapnia or transient artificial inflations. This relationship, sometimes found as hyperbolic, has been related to the BreuerHering reflex since, after vagotomy, TI seems only slightly dependent on VT 1. In the awake cat, on the other hand, changes in TI are variable and small when VT increases2 and the VT–TI relationship is therefore quite similar to that described for man by many authors. From these observations, it may be concluded that the Breuer-Hering reflex is stronger in the anesthetized cat than in the awake one. Since several reports have discussed the small role played by the Breuer-Hering reflex in the control of breathing of awake man3, it was of interest to know if the effect of anesthesia on the respiratory pattern was nhe same in man as in cat. Surprisingly, the components of breathing (VT, TI, TE, (\(\dot{V} \) I) have been studied very little in the anesthetized man. Studies have dealt mainly with the total ventilatory responses (\(\dot{V} \) E) to hypercapnia or hypoxia under different kinds of drugs.


Tidal Volume Breathing Pattern Breathing Rate Respiratory Pattern Inspiratory Time 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • H. Gautier
    • 1
  • J. H. Gaudy
    • 1
  • M. Bonora
    • 1
  1. 1.Laboratoire de Physiologie et Départment d’AnesthésiologieFaculté de Médecine Saint-Antoine 27 rue ChalignyParisFrance

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