Isolation and Identification of Oxidized Metabolites of Phenazopyridine from Rat Urine

  • D. Pitrè
  • R. Maffei-Facino
  • R. Tonani


Until recently all reports in the literature on the urinary metabolites of phenazopyridine (2,6-diamino-3-(phenylazopyridine)), a drug widely used for analgesia of the lower urinary tract (1), indicated that the in vivo metabolism involved reduction and splitting off the azo linkage. These metabolites included 2,3,6-triaminopyridine, aniline, 4-aminophenol, 2-aminophenol and 4-acetamidophenol (2, 3).


Migration Chloroform Pyridine Anhydride Aniline 


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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • D. Pitrè
    • 1
  • R. Maffei-Facino
    • 2
  • R. Tonani
    • 2
  1. 1.Bracco Industria ChimicaFarmaceuticaItaly
  2. 2.Istituto ChimicaFarmaceuticaItaly

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