Brain Monoamines, Monoamine Metabolites and Enzymes in Physiological Ageing and Senile Dementia

  • B. Winblad
  • R. Adolfsson
  • C. G. Gottfries
  • L. Oreland
  • B-E. Roos


When discussing ageing and the aged it is of importance to separate normal or physiological ageing or orthoinvolution from pathological ageing or pathoinvolution i.e. diseases which strike the human brain in middle and late age and cause neuron degeneration. Normal ageing will usually not induce severe mental impairment if no other complications arise, even if the individual reaches a very old age. Morphological investigations post mortem have shown that normal ageing does not affect all parts of the brain to the same extent. The degenerative changes observed are mostly in the limbic structures and cerebral cortex, especially lamina II and IV (1–3).


Senile Dementia Physiological Ageing Monoamine Metabolite Dementia Disorder Nucleus Caudatus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • B. Winblad
    • 1
  • R. Adolfsson
    • 1
  • C. G. Gottfries
    • 1
  • L. Oreland
    • 1
  • B-E. Roos
    • 2
  1. 1.University of UmeåSweden
  2. 2.Department of PsychaitryUniversity of UppsalaSweden

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