Brain Monoamines, Monoamine Metabolites and Enzymes in Physiological Ageing and Senile Dementia

  • B. Winblad
  • R. Adolfsson
  • C. G. Gottfries
  • L. Oreland
  • B-E. Roos

Abstract

When discussing ageing and the aged it is of importance to separate normal or physiological ageing or orthoinvolution from pathological ageing or pathoinvolution i.e. diseases which strike the human brain in middle and late age and cause neuron degeneration. Normal ageing will usually not induce severe mental impairment if no other complications arise, even if the individual reaches a very old age. Morphological investigations post mortem have shown that normal ageing does not affect all parts of the brain to the same extent. The degenerative changes observed are mostly in the limbic structures and cerebral cortex, especially lamina II and IV (1–3).

Keywords

Dopamine Dementia Noradrenaline Choline Catecholamine 

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References

  1. 1).
    H. Brody, J. Comp. Neurol., 1955, 102, 511.CrossRefGoogle Scholar
  2. 2).
    H. Brody, in “Interdisciplinary Topics in Gerontology”, H.T. Blumenthal, Ed., Karger, Basel, 1970, Vol. 7, p. 9.Google Scholar
  3. 3).
    H. Brody, in “Development and Ageing in the Central Nervous System”, M. Rockstein and M. Sussman, Eds., Academic Press, New York, 1973, p. 121.Google Scholar
  4. 4).
    A. Carlsson and B. Winblad, J. Neural. Transm., 1976, 38, 271.CrossRefGoogle Scholar
  5. 5).
    R. Adolfsson, C.G. Gottfries and B. Winblad, “Särtryck ur ASTRA: s bok ang. 2: a nordiska kongressen i gerontologi”, Göteborg, 1976, s. 60.Google Scholar
  6. 6).
    D.M. Bowen, C.B. Smith, P. White and A.N. Davison, Brain, 1976, 99, 459.CrossRefGoogle Scholar
  7. 7).
    P. Davies and A.J.F. Maloney, Lancet, 1976, 2 , 1403.CrossRefGoogle Scholar
  8. 8).
    P. White, M.J. Goodhardt, J.P. Keet, C.R. Hiley, L.H. Carrasco and I.E. Williams, Lancet, 1977, 1, 669.Google Scholar
  9. 9).
    J.A. Spillane, P. White, M.J. Goodhardt, R.H. Flack, D.M. Bowen and A.N. Davison, Nature, London, 1977, 266, 558.CrossRefGoogle Scholar
  10. 10).
    E.K. Perry, R.H. Perry, G. Blessed and B.E. Tomlinson, Lancet, 1977, 1, 189.CrossRefGoogle Scholar
  11. 11).
    D.S. Robinson, J.M. Davis, A. Nies, C.L. Ravaris and O. Sylwester, Arch. Gen. Psychiatr., 1971, 24, 536.Google Scholar
  12. 12).
    C.G. Gottfries, L. Oreland, A. Wiberg and B. Winblad, J. Neurochem., 1975, 35, 667.CrossRefGoogle Scholar
  13. 13).
    R. Adolfsson, G.G. Gottfries and B. Winblad, “Presented at the CINP’s Congress in Quebec”, Canada, July, 1976, in press.Google Scholar
  14. 14).
    S.M. Aquilonius, S.A. Eckernäs and A. Sundwall, J. Neurol. Neurosurg. Psychiatry, 1975, 38, 669.CrossRefGoogle Scholar
  15. 15).
    C.E. Finch, Brain Res., 1973, 52, 262.CrossRefGoogle Scholar
  16. 16).
    C.E. Finch, Q. Rev. Biol., 1976, 51, 49.Google Scholar
  17. 17).
    S. Algeri, F. Ponzio, M. Bonati and N. Brunello, “Presented at the CINP’s Congress in Quebec”, Canada, July, 1976, in press.Google Scholar
  18. 18).
    E.G. McGeer, H.C. Fibiger, P.L. McGeer and V. Wickson, Exp. Gerontol., 1971, 6, 391.CrossRefGoogle Scholar
  19. 19).
    A. Varnadakis, Fed. Proc., 1975, 34, 89.Google Scholar
  20. 20).
    J.L. Meek, L. Bertilsson, D.L. Cheney, G. Zsilla and E. Costa, J. Gerontol., 1977, in press.Google Scholar
  21. 21).
    W.A. Himwich and H.E. Himwich, in “Handbook of Ageing and Individual”, J.E. Birren, Ed., Chicago, The University of Chicago Press, 1959, p. 187.Google Scholar
  22. 22).
    C.G. Gottfries, I. Gottfries, I. Johansson, R. Olsson, T. Persson, B.E. Roos and R. Sjöström, Neuropharmacology, 1971, 10, 664.CrossRefGoogle Scholar
  23. 23).
    M.A. Bowers and F.A. Gerbode, Nature, London, 1968, 219, 1256.CrossRefGoogle Scholar
  24. 24).
    D.S. Robinson, T.L. Sourkes, A. Nies, L.S. Harris, S. Spector, D.L. Barlett and I.S. Kaye, Arch. Gen. Psychiatr., 1977, 34, 89.Google Scholar
  25. 25).
    C.G. Gottfries and I. Gottfries, “Nykonstruerat psykogeriatriskt skattningsschema”, Stencil, S:t Lars sjukhus, Lund, 1968.Google Scholar
  26. 26).
    C.G. Gottfries, I. Gottfries and B.E. Roos, Br. J. Psychiatr., 1969, 115, 563.CrossRefGoogle Scholar
  27. 27).
    O. Guard, B. Renaud and G. Chazot, L’Encephale, 1976, II, 293.Google Scholar
  28. 28).
    C.G. Zelesia and W.M. Wanamaker, Dis. Nerv. Syst., 1972, 33, 577.Google Scholar
  29. 29).
    J. Pearce, Br. Med. J., 1974, 2, 445.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • B. Winblad
    • 1
  • R. Adolfsson
    • 1
  • C. G. Gottfries
    • 1
  • L. Oreland
    • 1
  • B-E. Roos
    • 2
  1. 1.University of UmeåSweden
  2. 2.Department of PsychaitryUniversity of UppsalaSweden

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