Distribution in Brain Areas of Carbamazepine and Carbamazepine-10,11-epoxide in 6-Hydroxydopamine Pretreated Rats

  • C. Pantarotto
  • V. Crunelli
  • A. Quattrone
  • P. Negrini
  • A. Frigerio
  • R. Samanin

Abstract

Brain monoamines may be involved not only in the electroconvulsive threshold but also in the anticonvulsant activity of antiepileptic drugs in laboratory animals. Increased susceptibility to electroconvulsions has been reported in mice and rats treated with drugs which deplete brain monoamines, such as reserpine, a-methylparatyrosine and parachlorophenylalanine (1–4). These findings, together with reports on the anticonvulsant activity of two amine precursors, 1-dopa and 5-hydroxytryptophan (4, 5), and d-amphetamine (3), have led to the suggestion that brain monoamines may play a role in seizure susceptibility

Keywords

Dopamine Serotonin Noradrenaline Catecholamine Diphenylhydantoin 

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • C. Pantarotto
    • 1
  • V. Crunelli
    • 1
  • A. Quattrone
    • 1
  • P. Negrini
    • 1
  • A. Frigerio
    • 1
  • R. Samanin
    • 1
  1. 1.Istituto di Ricerche Farmacologiche “Mario NegriVia EritreaItaly

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