Direct Quantification of Apovincaminic Acid Ethyl Ester (cavinton (R)) in Human Plasma and Urine by Mass Fragmentography

  • G. Czira
  • L. Vereczkey
  • J. Tamás
  • L. Szporny


Cavinton is a new vincamine derivative with vasodilator effect on brain arteries (1–3). The pharmacokinetics and metabolism of the drug in rats were studied by using the tritiated compound (4–7), but little is known about the fate of Cavinton in the human body. Knowledge of the pharmacokinetics of a new drug, however, is desirable since it is essential both for a better understanding of its mechanism of action and for a rational treatment schedule.


Ethyl Citrate Chloroform Fluoride Alkaloid 


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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • G. Czira
    • 1
  • L. Vereczkey
    • 2
  • J. Tamás
    • 1
  • L. Szporny
    • 2
  1. 1.Central Research Inst. ChemistryHungarian Academy SciencesHungary
  2. 2.Chemical Works of Gedeon Richter Ltd.Hungary

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