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Recent Developments in Mass Spectrometry in Biochemistry and Medicine pp 1–14Cite as

Newer Aspects of the Biotransformation of Carbamazepine: Structural Characterization of Highly Polar Metabolites

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Abstract

Carbamazepine (5-carbamy l-5H-dibenzo [b,f ]azepine), the active ingredient of TEGRETOL (R) has played a key role in the treatment of epilepsy and trigeminal neuralgia since its introduction in the early 1960’s. In the time elapsed, about 300 papers have appeared that deal with the metabolism and the pharmacokinetics of this drug (for reviews see refs. 1, 2). Nonetheless, our knowledge of the biotransformation of carbamazepine has remained rather fragmentary for a long time. Now we wish to report on some progress made in exploring its metabolism in man.

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References

  1. P.L. Morselli and A. Frigerio, Metabolism and pharmacokinetics of carbamazepine. Drug. Metab. Rev., 1975, 4, 93.

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  2. J.W. Faigle, S. Brechbühler, K.F. Feldmann and W. J. Richter, in “Epileptic Seizures - Behaviour – Pain”, W. Birkmayer, Ed., W. Huber, Bern, 1976, p. 127.

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  3. S. Goenechea, G. Eckhardt and H.-D. Dersen, Isolierung und Identifizierung neuer Metaboliten des Carbamazepin (TEGRETOL (R)), Z. Anal. Chem., 1976, 279, 113.

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  4. J.E. Bauer, N. Gerber, R.K. Lynn, R.G. Smith and R.M. Thompson, Experientia, 1976, 32, 1032.

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  5. P. Kriemler and W.J. Richter, In situ methylation and/or FD-MS: a comparative study of their usefulness in the structure analysis of highly polar metabolites. 1977, this volume.

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Author information

Authors and Affiliations

  1. Central Function Research Pharmaceuticals Division, CIBA-GEIGY, Basel, Switzerland

    W. J. Richter & P. Kriemler

  2. Research Department Pharmaceuticals Division, CIBA-GEIGY, Basel, Switzerland

    J. W. Faigle

Authors
  1. W. J. Richter
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  2. P. Kriemler
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  3. J. W. Faigle
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Editor information

Editors and Affiliations

  1. “Mario Negri” Institute, Milan, Italy

    Alberto Frigerio

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© 1978 Plenum Press, New York

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Richter, W.J., Kriemler, P., Faigle, J.W. (1978). Newer Aspects of the Biotransformation of Carbamazepine: Structural Characterization of Highly Polar Metabolites. In: Frigerio, A. (eds) Recent Developments in Mass Spectrometry in Biochemistry and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3991-5_1

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  • DOI: https://doi.org/10.1007/978-1-4613-3991-5_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3993-9

  • Online ISBN: 978-1-4613-3991-5

  • eBook Packages: Springer Book Archive

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