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Inherited Membrane Disorders of Muscle: Duchenne Muscular Dystrophy and Myotonic Muscular Dystrophy

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Physiology of Membrane Disorders

Abstract

Our progress in understanding the pathogenesis of human muscular dystrophies has been extremely slow, despite the fact that the majority of such syndromes are inherited diseases, and our general progress in understanding other genetic diseases of man has moved at a rapidly accelerating pace. Such slow progress might be related primarily to our ignorance of the most appropriate biochemical approaches to these problems, but it can also be attributed to a relatively unproductive concentration of research efforts on muscle tissue which has undergone numerous secondary changes. In addition, considerable effort has been invested in experimental models of myotonia and dystrophy which bear only minimal resemblance to the human disorders.

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Authors and Affiliations

  1. Division of Neurology, Duke University Medical Center, Durham, North Carolina, 27710, USA

    Allen D. Roses

  2. Department of Neurology, Baylor University School of Medicine, Houston, Texas, 77030, USA

    Stanley H. Appel

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  1. Allen D. Roses
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Editors and Affiliations

  1. Division of Nephrology, University of Alabama School of Medicine, Birmingham, Alabama, 35294, USA

    Thomas E. Andreoli M.D. (Professor of Medicine, Director, Professor of Physiology and Biophysics) (Professor of Medicine, Director, Professor of Physiology and Biophysics)

  2. Department of Physiology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    Joseph F. Hoffman Ph.D. (Eugene Higgins Professor and Chairman) (Eugene Higgins Professor and Chairman)

  3. Division of Nephrology, University of California, San Diego, La Jolla, California, 92037, USA

    Darrell D. Fanestil M.D. (Professor of Medicine, Head) (Professor of Medicine, Head)

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Roses, A.D., Appel, S.H. (1978). Inherited Membrane Disorders of Muscle: Duchenne Muscular Dystrophy and Myotonic Muscular Dystrophy. In: Andreoli, T.E., Hoffman, J.F., Fanestil, D.D. (eds) Physiology of Membrane Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3958-8_38

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  • DOI: https://doi.org/10.1007/978-1-4613-3958-8_38

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