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The Anatomy of Biological Interfaces

  • Chapter
Physiology of Membrane Disorders

Abstract

It is generally recognized that biological membranes have a common, basic lipid bilayer structure(179,180,191,193,231) which contains external, internal, and transmembrane proteins with chemical asymmetry as a fundamental feature(215–217); the asymmetry involves both lipids and proteins (see Rothman and Lenard(201) for a recent review). Certain glycoproteins such as glycophorin in erythrocyte membranes(146,207) are arranged with a protein moiety in the internal leaflet connected to a glycoprotein moiety in the external leaflet.(241) In the case of glycophorin, the internal and external moieties are connected by a stretch of hydrophobic amino acid residues traversing the bilayer probably as an α helix.

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Authors and Affiliations

  1. Department of Anatomy, Duke University Medical Center, 27710, Durham, North Carolina, USA

    J. David Robertson

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  1. J. David Robertson
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Editors and Affiliations

  1. Division of Nephrology, University of Alabama School of Medicine, Birmingham, Alabama, 35294, USA

    Thomas E. Andreoli M.D. (Professor of Medicine, Director, Professor of Physiology and Biophysics) (Professor of Medicine, Director, Professor of Physiology and Biophysics)

  2. Department of Physiology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    Joseph F. Hoffman Ph.D. (Eugene Higgins Professor and Chairman) (Eugene Higgins Professor and Chairman)

  3. Division of Nephrology, University of California, San Diego, La Jolla, California, 92037, USA

    Darrell D. Fanestil M.D. (Professor of Medicine, Head) (Professor of Medicine, Head)

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© 1978 Plenum Publishing Corporation

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Robertson, J.D. (1978). The Anatomy of Biological Interfaces. In: Andreoli, T.E., Hoffman, J.F., Fanestil, D.D. (eds) Physiology of Membrane Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3958-8_1

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  • DOI: https://doi.org/10.1007/978-1-4613-3958-8_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3960-1

  • Online ISBN: 978-1-4613-3958-8

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