Skip to main content
SpringerLink
Log in

Oral Complications of Bone-Marrow Transplantation

  • Chapter
Oral Complications of Cancer Chemotherapy

Part of the book series: Developments in Oncology ((DION,volume 12))

Abstract

The techniques for bone-marrow transplantation grew out of the studies by Jacobson, et al. [1] and Lorenz et al. [2], first reported in 1950. They showed that lethally irradiated mice could survive if the spleen was adequately shielded or if an infusion of bone-marrow cells was given. Initial efforts in man to utilize the technique of marrow infusion following lethal radiation demonstrated the potential usefulness of this technique but were generally unsuccessful. In the late 1950s two leukemia patients given supralethal radiation demonstrated successful engraftment after marrow infusion from identical twin donors but later succumbed to recurrent disease [3]. With the advances in kidney transplantation in the 1960s, the role of histocompatability matching between donor and recipient was appreciated. Elucidation of the histocompatability leukocyte antigen (HLA) complex facilitated marrow transplantation between HLA-identical siblings. In the early 1970s marrow transplantation was further enhanced with the development of better supportive care for patients following marrow ablation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Jacobson LO, Simmons EL, Marks EK, et al.: The role of the spleen in radiation injury and recovery. J Lab Clin Med (35):746–770, 1950.

    PubMed  CAS  Google Scholar 

  2. Lorenz E, Uphoff D, Reid TR, Shelton E: Modification of irradiation injury in mice and guinea pigs by bone marrow injections. J Natl Cancer Inst (12):197–201, 1951.

    PubMed  CAS  Google Scholar 

  3. Thomas ED, Lochte HLJr, Lu WC, Ferrebee JW: Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy. N Engl J Med (257):491–496, 1957.

    Article  PubMed  CAS  Google Scholar 

  4. Camitta BM, Thomas ED, Nathan DG, Gale RP, Kopecky KJ, Rapport JM, Santos G, Gordon-Smith EC, Storb R: A prospective study of androgens and bone marrow transplantation for treatment of severe aplastic anemia. Blood (53):504–514, 1979.

    PubMed  CAS  Google Scholar 

  5. Storb R, Doney KC, Thomas ED, Appelbaum F, Buckner CD, Clift RA: Marrow transplantation with or without buffy coat cells for 65 transfused aplastic anemia patients. Blood (59):236–246, 1982.

    PubMed  CAS  Google Scholar 

  6. Storb R, Thomas ED, Buckner CD, Clift RA, Deeg HS, Fefer A, Goodell RW, Sale GE, Sanders J, Singer J, Stewart P, Weiden PL: Marrow transplantation in thirty “untransfused” patients with severe aplastic anemia. Ann Intern Med (92):30–36, 1980.

    PubMed  CAS  Google Scholar 

  7. Thomas ED, Buckner ED, Clift RA, Fefer A, Johnson FL, Neiman PE, Sale GE, Sanders JE, Singer JW, Shulman H, Storb R, Weiden PL: Marrow transplantation for acute nonlymphoblastic leukemia in first remission. N Engl J Med (301):597–599, 1979.

    Article  PubMed  CAS  Google Scholar 

  8. Fefer A, Cheever MA, Greenberg PD, Appelbaum FR, Boyd W, Buckner CD, et al.: Treatment of chronic granulocytic leukemia with chemoradiotherapy and transplantation of marrow from identical twins. N Engl J Med (306):63–68, 1982.

    Article  PubMed  CAS  Google Scholar 

  9. Hansen JA, Clift RA, Thomas ED, Buckner CD, Storb R, Giblett ER: Transplantation of marrow from an unrelated donor to a patient with acute leukemia. N Engl J Med (303):565–567, 1980.

    Article  PubMed  CAS  Google Scholar 

  10. Thomas DE: Bone marrow transplantation: Present status and future expectations. In Update I; Harrison’s Principles of Internal Medicine, Issenbach KJ, Adams RA, Braunwald E, Martin JB, Petersdorf RG, Wilson JD (eds), New York, McGraw-Hill, 1981.

    Google Scholar 

  11. Appelbaum FR, Fefer A, Cheever MA, Sanders JE, Singer JW, Adamson JW, Mickelson EM, Hansen JA, Greenberg PD, Thomas ED: Treatment of aplastic anemia by bone marrow transplantation in identical twins. Blood (55):1033–1039, 1980.

    PubMed  CAS  Google Scholar 

  12. Clift RA, Hansen JA, Thomas ED: The role of HLA in marrow transplantation. Transplant Proc (13):- 234–236, 1981.

    PubMed  CAS  Google Scholar 

  13. Thomas ED, Storb R, Clift RA, Fefer A, Johnson FL, Neiman PE, Lerner KG, Glucksberg H, Buckner CD: Bone marrow transplantation. N Engl J Med (292):832–843, 895–902, 1975.

    Article  PubMed  CAS  Google Scholar 

  14. Neiman P, Thomas ED, Buckner CD, Storb R, Fefer A, Glucksberg H, Lerner KG: Marrow transplantation for aplastic anemia and acute leukemia. Ann Rev Med (25):179–198, 1974.

    Article  PubMed  CAS  Google Scholar 

  15. Meyers JD, Thomas ED: Infection complicating bone marrow transplantation. In Clinical Approach to Infection in the Immunocompromised Host, Young LS, Rubin RH (eds), New York, Plenum, 1981.

    Google Scholar 

  16. Buckner CD, Clift RA, Sanders JE, Meyers JD, Counts GW, Farewell VT, Thomas ED: Protective environment for marrow transplant recipients. A prospective study. Ann Int Med (89):893–901, 1978.

    CAS  Google Scholar 

  17. Clift RA, Sanders JE, Thomas ED, Williams B, Buckner CD: Granulocyte transfusions for the prevention of infection in patients receiving bone marrow transplants. N Engl J Med (298):1052–1057, 1978.

    Article  PubMed  CAS  Google Scholar 

  18. Sarai R, Burns WH, Laskin DL, Santos GW, Lietman P: Acyclovir prophylaxis of herpes simplex infections: A randomized, double blind, controlled trial in bone marrow transplant recipients. N Engl J Med (305):63–67, 1981.

    Article  Google Scholar 

  19. Hickman RO, Buckner CO, Clift RA, Sanders JE, Stewart P, Thomas ED: A modified right arterial catheter for access to the venous system in marrow transplant recipients. Surg Gynecol Obstet (148):871–875, 1979.

    PubMed  CAS  Google Scholar 

  20. Storb R: Bone marrow transplantation for the treatment of hematologic malignancy and of aplastic anemia. Transplant Proc (13):221–226, 1981.

    PubMed  CAS  Google Scholar 

  21. Slavin RE, Santos GW: The graft-versus-host reaction in man after bone marrow transplantation: Pathology, pathogenesis, clinical features and implications. Clin Immunol Immunopathol (1):472–498, 1973.

    Article  PubMed  CAS  Google Scholar 

  22. Glucksberg H, Storb R, Fefer A, Buckner CD, Neiman PE, Clift RA, Lerner KG, Thomas ED; Clinical manifestations of graft-versus-host disease in human recipients of marrow from HLA matched sibling donors. Transplantation (18):295–304, 1974.

    Article  PubMed  CAS  Google Scholar 

  23. Shulman HM, Sullivan KM, Weiden PL, McDonald GB, Striker GE, Sale GE, Hackman R, Tsoi MS, Storb R, Thomas ED: Chronic graft-versus-host syndrome in man. A long term clinicopathologic study of 20 Seattle patients. Am J Med (69):204–217, 1982.

    Article  Google Scholar 

  24. Atkinson K, Storb R, Prentice RL, Weiden P, Witherspoon RP, Sullivan KM, Noel D, Thomas ED: Analysis of late infections in 89 long term survivors of bone marrow transplantation. Blood (53):720–731, 1979.

    PubMed  CAS  Google Scholar 

  25. Powles RL, Clink HM, Spence D, Morgenstern G, Watson JG, Selby PJ, Woods M, Barrett A, Jameson B, Sloane J, Lawler SD, Kay H, Lawson D, McElwain T, Alexander P: Cyclosporin A to prevent graft-versus- host disease in man after allogeneic bone marrow transplantation. Lancet (8164):327—329, 1980.

    Article  Google Scholar 

  26. Weiden PL, Fluornoy N, Sanders JF, Sullivan KM, Thomas ED: Antileukemic effect of graft-versus-host disease contributes to improved survival after allogeneic marrow transplantation. Transplant Proc (12):- 248–251, 1981.

    Google Scholar 

  27. Sullivan KM, Shulman HM, Storb R, Weider PL, Witherspoon RP, McDonald GB, Schubert MM, Atkinson K, Thomas ED: Chronic graft-versus-host disease in 52 patients: Adverse natural course and successful treatment with combination immunosuppression. Blood (57):267–276, 1981.

    PubMed  CAS  Google Scholar 

  28. Witherspoon RP, Kopecky K, Storb RF, Fluornoy N, Sullivan KM, Sosa R, Deeg HJ, Ochs HD, Cheevers MA, Fefer A, Thomas ED: Immunological recovery in 48 patients following syngeneic marrow transplantation for hematological malignancy. Transplantation (33):143–149, 1982.

    Article  PubMed  CAS  Google Scholar 

  29. Witherspoon RP, Storb R, Ochs Hd, Flournoy N, Kopecky K, Sullivan KM, Deeg HJ, Sosa R, Noel DR, Atkinson K, Thomas ED: Recovery of antibody, production in human allogeneic marrow graft recipients: Influence of time post transplantation, the presence or absence of chronic graft-versus-host disease, and antithymocyte globulin treatment. Blood (58):360–368, 1981.

    PubMed  CAS  Google Scholar 

  30. Tsoi MS, Storb R, Dobbs S, Kopecky KJ, Santos E, Weiden PL, Thomas ED: Nonspecific suppressor cells in patients with chronic graft-versus-host disease after marrow grafting. J Immunol (123):1970–1976, 1979.

    PubMed  CAS  Google Scholar 

  31. Tsoi MS, Storb R, Dobb S, Thomas ED: Specific suppressor cells in graft-host tolerance of HLA-identical marrow transplantation. Nature (292):355–357, 1981.

    Article  PubMed  CAS  Google Scholar 

  32. Lockhart PB, Sonis ST: Relationship of oral complications to peripheral blood leukocyte and platelet counts in patients receiving cancer chemotherapy. Oral Surg (48):21–28, 1979.

    Article  PubMed  CAS  Google Scholar 

  33. Dreizen S, Bodey GP, Rodriquez V: Oral complications of cancer chemotherapy. Postgrad Med (58):75–82, 1975.

    PubMed  CAS  Google Scholar 

  34. Silverman S: Radiation effects. In Oral Cancer, Silverman S (ed), New York, American Cancer Society, 1981.

    Google Scholar 

  35. Dreizen S: Stomatotoxic manifestations of cancer chemotherapy. J Prosthet Dent (40):650–655, 1978.

    Article  PubMed  CAS  Google Scholar 

  36. Gershwin ME, Goetzl EJ, Steinberg AD: Cyclophosphamide: Use in practice. Ann Intern Med (80):531–540, 1974.

    PubMed  CAS  Google Scholar 

  37. Chabner BA, Myers CE, Coleman CN, Johns DG: The clinical pharmacology of antineoplastic agents. N Engl J Med (292):1107–1113, 1159–1168, 1975.

    Article  PubMed  CAS  Google Scholar 

  38. Dreizen S, Bodey GP, Brown LR: Opportunistic gram-negative bacillary infections in leukemia—oral manifestations during myelosuppression. Postgrad Med (55):133–139, 1974.

    PubMed  CAS  Google Scholar 

  39. Solberg CO, Meuwissen HJ, Needham RN, Good RA, Matsen JM: Infectious complications in bone marrow transplant patients. Br Med J (l):18–23, 1971.

    Article  Google Scholar 

  40. Dreizen S, McCredie KB, Sicke KA, Zander AR, Peters JL: Oral complications of bone marrow transplantation in adults with acute leukemia. Postgrad Med (66):187–194, 1979.

    PubMed  CAS  Google Scholar 

  41. Morris PG: Cyclosporin A: Overview. Transplantation (32):349–354, 1981.

    Article  PubMed  CAS  Google Scholar 

  42. Schubert MM, Truelove EL, Sullivan KM, Izutsu KT, Flournoy N, Kolbinson DA: Oral signs of chronic graft-versus-host disease. Proc J Dent Res (68):263, 1982.

    Google Scholar 

  43. Sale GE, Shulman HM, Schubert MM, Sullivan KM, Kopecky KJ, Hackman RC, Morton TH, Storb R, Thomas ED: Oral and opthalmic pathology of graft versus host disease in man: Predictive value of the lips biopsy. Hum Pathol (12):1022–1030, 1981.

    Article  PubMed  CAS  Google Scholar 

  44. Gratwohl AA, Moutsopoulos HM, Chused TM, Akizuki M, Wolf RO, Sweet JB, Reisseroth AB: Sjogren-type syndrome after allogeneic bone marrow transplantation. Ann Intern Med 87:703—706, 1977.

    PubMed  CAS  Google Scholar 

  45. Mandel ID, Burmash H: Sialochemistry in Sjogren’s syndrome. Oral Surg, Oral Med, Oral Pathol (41): 182–187, 1976.

    Article  CAS  Google Scholar 

  46. Moutsopoulous H, Karsh J, Wolf R, Tarpley T: Lysozyme determination in parotid saliva from patients with Sjogren’s syndrome. Am J Med (69):39–42, 1980.

    Article  Google Scholar 

  47. Izutsu K, Oberg S, Shulman H, Schubert M, Sullivan K, Morton T, Sale G, Truelove E: Depressed salivary IgA; and sodium and flow changes in C-GVHD patients. J Supramol Struct (Suppl A):24, 1980.

    Google Scholar 

  48. Izutsu KT, Schubert MM, Shulman H, Oberg S, Sullivan KM, Rice J, Morton T, Truelove E: Salivary changes in graft-versus-host disease (GVHD) Proc J Dent Res (95-A): 401, 1980.

    Google Scholar 

  49. Izutsu KT, Truelove EL, Schubert MM, Ensign WY, Meadows EE: Does graft-versus-host disease cause hyposalivation in bone marrow transplant recipients? Proc J Dent Res (68):263, 1982.

    Google Scholar 

  50. Truelove EL, Izutsu KT, Schubert MM, Ensign WT, Meadows EE: Salivary lysozyme levels are increased in bone marrow transplant (BMT) recipients. Proc J Dent Res (68):223, 1982.

    Google Scholar 

  51. Izutsu KT, Schubert MM, Truelove EL, Shulman HM, Sale GE, Morton TH, Ensign WY, Mersai T, Thomas DE: The predictive value of elevated sodium concentration: Its relation to labial gland pathology in bone marrow transplant recipients. Hum Pathol (May 1982, in press).

    Google Scholar 

  52. Beschorner WE, Yardley JH, Tutschka PJ, Santos GW: Deficiency of intestinal immunity with graft-versus- host disease in humans. J Infect Dis (144):38–46, 1981.

    Article  PubMed  CAS  Google Scholar 

  53. Peterson DE, Overholser CD, Williams LT: Endodontic therapy in patients receiving myelosuppressive chemotherapy. Proc J Dent Res (61):276, 1982.

    Google Scholar 

  54. Rakocz M, Serota FT, Nelson LP, Reich DR, Werther PL, August CS: Dental management of the child undergoing bone marrow transplantation, JADA (104):485–488, 1982.

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Mark M. Schubert D.D.S., M.S.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Keith M. Sullivan M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kenneth T. Izutsu PhD.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Edmond L. Truelove D.D.S., M.S.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Oral Diagnosis, Baltimore College of Dental Surgery, Baltimore, MD, USA

    Douglas E. Peterson

  2. University of Maryland School of Medicine, Baltimore, MD, USA

    Douglas E. Peterson

  3. Division of Dentistry, Brigham and Women’s Hospital, Boston, MA, USA

    Stephen T. Sonis

  4. Harvard School of Dental Medicine, Boston, MA, USA

    Stephen T. Sonis

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Martinus Nijhoff Publishing, The Hague/Boston/London

About this chapter

Cite this chapter

Schubert, M.M., Sullivan, K.M., Izutsu, K.T., Truelove, E.L. (1983). Oral Complications of Bone-Marrow Transplantation. In: Peterson, D.E., Sonis, S.T. (eds) Oral Complications of Cancer Chemotherapy. Developments in Oncology, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3912-0_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-3912-0_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3914-4

  • Online ISBN: 978-1-4613-3912-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation