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Oral Complications of Cancer Chemotherapy pp 79–91Cite as

Bacterial Infections: Periodontal and Dental Disease

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Part of the book series: Developments in Oncology ((DION,volume 12))

Abstract

Infections in the myelosuppressed cancer patient are serious sequelae of both the natural disease as well as the chemotherapy used in its treatment. For example, infection is the leading cause of morbidity and mortality in patients with acute nonlymphocytic leukemia (ANLL) [1,2]. Prevention, recognition, and treatment of acute infections in the cancer patient receiving chemotherapy are critical to his/her quality and duration of life.

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References

  1. Schimpff SC, Young VM, Greene WH, Vermeulen GD, Moody MR, Wiernik PH: Origin of infection in acute nonlymphocytic leukemia: significance of hospital acquisition of potential pathogens. Ann Intern Med 77:707–714, 1972.

    PubMed  CAS  Google Scholar 

  2. Levine AS, Schimpff SC, Graw RG, Young RC: Hematologic malignancies and other marrow failure states: progress in the management of complicating infections. Semin Hematol 11:141–202, 1974.

    PubMed  CAS  Google Scholar 

  3. Gillespie GM: Renewal of buccal epithelium. Oral Surg 27:83–89, 1969.

    Article  PubMed  CAS  Google Scholar 

  4. Bottomley WK, Perlin E, Ross GR: Antineoplastic agents and their oral manifestations. Oral Surg 44:527–534, 1977.

    Article  PubMed  CAS  Google Scholar 

  5. Dreizen S: Stomatotoxic manifestations of cancer chemotherapy. J Prosthet Dent 40:650–655, 1978.

    Article  PubMed  CAS  Google Scholar 

  6. Lindquist SF, Hickey AJ, Drane JB: Effect of oral hygiene on stomatitis in patients receiving cancer chemotherapy. J Prosthet Dent 40:312–314, 1978.

    Article  PubMed  CAS  Google Scholar 

  7. Beck S: Impact of a systematic oral care protocol on stomatitis after chemotherapy. Cancer Nurs 2:185–199, 1979.

    Article  PubMed  CAS  Google Scholar 

  8. Dreizen S, McCredie KB, Dicke KA, Zander AR, Peters LJ: Oral complications of bone marrow transplantation in adults with acute leukemia. Postgrad Med 66:187–196, 1979.

    PubMed  CAS  Google Scholar 

  9. Daeffler R: Oral hygiene measures for patients with cancer (I). Cancer Nurs 3:347–356, 1980.

    PubMed  CAS  Google Scholar 

  10. Ostchega Y: Preventing and treating cancer chemotherapy’s oral complications. Nursing 10:47–52, 1980.

    PubMed  CAS  Google Scholar 

  11. Daeffler R: Oral hygiene measures for patients with cancer (II). Cancer Nurs 3:427–132, 1980.

    PubMed  CAS  Google Scholar 

  12. Daeffler R: Oral hygiene measures for patients with cancer (III). Cancer Nurs 4:29–35, 1981.

    Article  PubMed  CAS  Google Scholar 

  13. Dreizen S: Chemotherapy-induced oral mucositis in adult leukemia. Postgrad Med 69:103–112, 1981.

    PubMed  CAS  Google Scholar 

  14. Hickey AJ, Toth BB, Lindquist SB: Effect of intravenous hyperalimentation and oral care on the development of oral stomatitis during cancer chemotherapy. J Prosthet Dent 47:188–193, 1982.

    Article  PubMed  CAS  Google Scholar 

  15. Loesche WJ: Bacterial succession in dental plaque: role in dental disease. In Microbiology—1975, Schlessinger D (ed), Washington, D.C., American Society of Microbiologists, 1975:132–136.

    Google Scholar 

  16. Page RC, Schroeder HE: Pathogenesis of inflammatory periodontal disease. Lab Invest 34:235–249, 1976.

    PubMed  CAS  Google Scholar 

  17. Goldman HM, Cohn DW: Periodontal Therapy, 4th ed., St. Louis, C.V. Mosby Co, 1968, p. 64.

    Google Scholar 

  18. Segelman AE, Doku HC: Treatment of the oral complications of leukemia. J Oral Surg 35:469–477, 1977.

    PubMed  CAS  Google Scholar 

  19. Sonis ST, Sonis AL, Lieberman A: Oral complications in patients receiving treatment for malignancies other than of the head and neck. J Am Dent Assoc 97:468–472, 1978.

    PubMed  CAS  Google Scholar 

  20. Lockhart PB, Sonis ST: Relationship of oral complications to peripheral blood leukocyte and platelet counts in patients receiving cancer chemotherapy. Oral Surg 48:21–28, 1979.

    Article  PubMed  CAS  Google Scholar 

  21. Peterson DE, Overholser CD: Dental management of leukemic patients. Oral Surg 47:40–42, 1979.

    Article  PubMed  CAS  Google Scholar 

  22. Sonis A, Sonis S: Oral complications of cancer chemotherapy in pediatric patients. J Periodontal 3:122–128, 1979.

    CAS  Google Scholar 

  23. Peterson DE, Overholser CD: Increased morbidity associated with oral infection in patients with acute nonlymphocytic leukemia. Oral Surg 51:390–393, 1981.

    Article  PubMed  CAS  Google Scholar 

  24. Greenberg MS, Cohen SG, McKitrick JC, Cassileth PA: The oral flora as a source of septicemia in patients with acute leukemia. Oral Surg 53:32–36, 1982.

    Article  PubMed  CAS  Google Scholar 

  25. Overholser CD, Peterson DE, Williams LT, Schimpff SC: Periodontal infection in patients with acute nonlymphocytic leukemia: prevalence of acute exacerbations. Arch Intern Med 142:551–554, 1982.

    Article  PubMed  CAS  Google Scholar 

  26. Johanson WG, Pierce AK, Sanford JP: Changing pharyngeal bacterial flora of hospitalized patients. N Engl J Med 281:1137–1140, 1969.

    Article  PubMed  CAS  Google Scholar 

  27. Brown LR, Mackler BF, Levy BM, et al.: Comparison of the plaque microflora in immunodeficient and immunocompetent dental patients. J Dent Res 58:2344–2352, 1979.

    Article  PubMed  CAS  Google Scholar 

  28. Brown LR, Dreizen S, Bodey GP: Effect of immunosuppression on the human oral flora. In Comparative Immunology of the Oral Cavity, Mergenhagen SE, Scherp HW (eds), Washington, D.C., U.S. Government Printing Office, 1973, pp. 204–220.

    Google Scholar 

  29. Schimpff SC, Aisner J, Wiernik PH: Infection in acute nonlymphocytic leukemia: the alimentary canal as a major source of pathogens. In New Criteria for Antimicrobial Therapy: Maintenance of Digestive Tract Colonization Resistance, van der Waaij D, Verhoef J (eds), Amsterdam, Excerpta Medica, 1979, pp 12–29.

    Google Scholar 

  30. Newman KA, Schimpff SC, Young VM, Wiernik PH: Lessons learned from surveillance cultures in patients with acute nonlymphocytic leukemia. Am J Med 70:423–431, 1981.

    Article  PubMed  CAS  Google Scholar 

  31. Chapman RM, Crosby WH: Elective dental extraction in leukemia (letter). N Engl J Med 295:114, 1976.

    PubMed  CAS  Google Scholar 

  32. Parfitt GJ: Cleansing the subgingival space. J Periodontol 34:133–139, 1963.

    Google Scholar 

  33. Vollmer DE: Preventive dentistry: precaution pays. J Am Soc Prev Dent 4:31–33, 1974.

    PubMed  CAS  Google Scholar 

  34. Schimpff SC, Satterlee W, Young VM, Serpick A: Empiric therapy with carbenicillin and gentamicin for febrile patients with cancer and granulocytopenia. N Engl J Med 284:1061–1065, 1971.

    Article  PubMed  CAS  Google Scholar 

  35. Bodey GP, Buckley M, Sathe YS, Freireich EJ: Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. Ann Intern Med 64:328–340, 1966.

    PubMed  CAS  Google Scholar 

  36. Sickles EA, Greene WH, Wiernik PH: Clinical presentation of infection in granulocytopenic patients. Arch Intern Med 135:715–719, 1975.

    Article  PubMed  CAS  Google Scholar 

  37. Greene JC, Vermillion JR: The simplified oral hygiene index. J Am Dent Assoc 68:7–13, 1964.

    PubMed  CAS  Google Scholar 

  38. Schimpff SC: Therapy of infection in patients with granulocytopenia. Med Clin North Am 1101–1118,1977.

    Google Scholar 

  39. Cobe HM: Transitory bacteremia. Oral Surg 7:609–615, 1954.

    Article  PubMed  CAS  Google Scholar 

  40. Conner HD, Haberman S, Collings CK, Winford TE: Bacteremias following periodontal scaling in patients with healthy appearing gingiva. J Periodontal 38:22–28, 1967.

    Google Scholar 

  41. Lineberger LT, DeMarco TJ: Evaluation of transient bacteremia following routine periodontal procedures. J Periodontol 44:757–762, 1973.

    PubMed  CAS  Google Scholar 

  42. Sconyers JR, Crawford JJ, Moriarity JD: Relationship of bacteremia to toothbrushing in patients with periodontitis. J Am Dent Assoc 87:616–622, 1973.

    PubMed  CAS  Google Scholar 

  43. Wank HA, Levinson ME, Rose LF, Cohen DW: A quantitative measurement of bacteremia and its relationship to plaque control. J Periodontol 47:683–686, 1976.

    PubMed  CAS  Google Scholar 

  44. Silver JG, Martin AW, McBride BC: Experimental transient bacteraemias in human subjects with varying degrees of plaque accumulation and gingival inflammation. J Clin Periodontol 4:92–99, 1977.

    Article  PubMed  CAS  Google Scholar 

  45. Silver JC, Martin AW, McBride BC: Experimental transient bacteraemias in human subjects with clinically healthy gingivae. J Clin Periodontol 6:33–36, 1979.

    Article  PubMed  CAS  Google Scholar 

  46. Carroll GC, Sebor RJ: Dental flossing and its relationship to transient bacteremia. J Periodontol 51:691–692, 1980.

    PubMed  CAS  Google Scholar 

  47. Berger SA, Weitzman S, Edberg SC, Casey JI: Bacteremia after the use of an oral irrigation device. Ann Intern Med 80:510–511, 1974.

    PubMed  CAS  Google Scholar 

  48. Kremer WB, Vogler WR, Chan YK: An attempt at synchronization of marrow cells in acute leukemia. Cancer 37:390–403, 1976.

    Article  PubMed  CAS  Google Scholar 

  49. Kansal V, Omura GA, Soong SJ: Prognosis in adult acute myelogenous leukemia related to performance status and other factors. Cancer 38:329–334, 1976.

    Article  PubMed  CAS  Google Scholar 

  50. Peterson DE, Overholser CD, Williams LT, Newman KA, Schimpff SC, Wiernik PH. Acute periodontal infection at admission in acute nonlymphocytic leukemia patients. Proc Am Fed Clin Res 30:422A, 1982.

    Google Scholar 

  51. Suzuki JB, DePaola LG, Nauman RK: Periodontal therapy in a patient on cancer chemotherapy. J Am Dent Assoc 104:473–475, 1982.

    PubMed  CAS  Google Scholar 

  52. Weekly Clinicopathological Exercises, Case 36–1977. N Engl J Med 297:546–551, 1977.

    Article  Google Scholar 

  53. Levinson SL, Barondess JA: Occult dental infection as a cause of fever of obscure origin. Am J Med 66:463–467, 1979.

    Article  PubMed  CAS  Google Scholar 

  54. Peterson DE, Overholser CD, Williams LT: Endodontic therapy in patients receiving myelosuppressive chemotherapy. Proc J Dent Res 61:276, 1982.

    Google Scholar 

  55. Overholser CD, Peterson DE, Bergman SA: Dental extractions in patients with leukemia. J Oral Surg 40:296–298, 1982.

    Article  CAS  Google Scholar 

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Authors
  1. Douglas E. Peterson D.M.D., Ph.D.
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Editor information

Editors and Affiliations

  1. Department of Oral Diagnosis, Baltimore College of Dental Surgery, Baltimore, MD, USA

    Douglas E. Peterson

  2. University of Maryland School of Medicine, Baltimore, MD, USA

    Douglas E. Peterson

  3. Division of Dentistry, Brigham and Women’s Hospital, Boston, MA, USA

    Stephen T. Sonis

  4. Harvard School of Dental Medicine, Boston, MA, USA

    Stephen T. Sonis

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© 1983 Martinus Nijhoff Publishing, The Hague/Boston/London

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Peterson, D.E. (1983). Bacterial Infections: Periodontal and Dental Disease. In: Peterson, D.E., Sonis, S.T. (eds) Oral Complications of Cancer Chemotherapy. Developments in Oncology, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3912-0_5

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  • DOI: https://doi.org/10.1007/978-1-4613-3912-0_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3914-4

  • Online ISBN: 978-1-4613-3912-0

  • eBook Packages: Springer Book Archive

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