Epidemiology, Frequency, Distribution, Mechanisms, and Histopathology

  • Stephen T. Sonis
Part of the Developments in Oncology book series (DION, volume 12)

Abstract

The number of newly diagnosed patients with malignant disease continues to rise annually. Fortunately, the prognostic outlook for these individuals is no longer universally grim. Significant progress has been made in understanding cancer biology and natural defense mechanisms and in the development of new and aggressive treatment modalities. There is evidence of an overall increase in survival time and, in a growing number of cases, the opportunity for curative therapy.

Keywords

Toxicity Lymphoma Leukemia Anemia Oncol 

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References

  1. 1.
    Sonis ST, Sonis AL, Lieberman A: Oral complications in patients receiving treatment for malignancies other than of the head and neck. J Am Dent Assoc 97:468–472, 1978.PubMedGoogle Scholar
  2. 2.
    Sonis AT, Sonis ST: Oral complications of cancer chemotherapy in pediatric patients. J Pedodontics 3:122–128, 1979.Google Scholar
  3. 3.
    Dreizen S, Bodey GP, Brown LR: Opportunistic gram-negative bacillary infections in leukemia. Oral manifestations during myelosuppression. Postgrad Med 55:133–139, 1974.PubMedGoogle Scholar
  4. 4.
    The EORTC International Antimicrobial Therapy Project Group: Three antibiotic regimens in the treatment of infection in febrile granulocytopenic patients with cancer. J Infect Dis 137:14–29, 1978.CrossRefGoogle Scholar
  5. 5.
    Guggenheimer J, Verbin RS, Appel BN, Schmitz J: Clinicopathologic effects of cancer chemotherapeutic agents on human buccal mucosa. Oral Surg 44:58—63, 1977.PubMedCrossRefGoogle Scholar
  6. 6.
    Lockhart PB, Sonis ST: Relationship of oral complications to peripheral blood leukocyte and platelet counts in patients receiving cancer chemotherapy. Oral Surg 48:21—28, 1979.PubMedCrossRefGoogle Scholar
  7. 7.
    Bodey GP: Oral manifestations of the myeloproliferative diseases. Postgrad Med 49:115–121, 1971.PubMedGoogle Scholar
  8. 8.
    Lynch MA, Ship II: Initial oral manifestations of leukemia. J Am Dent Assoc 75:932–940, 1967.PubMedGoogle Scholar
  9. 9.
    Stafford RF, Lockhart PB, Sonis AL, Sonis ST: Hematologic parameters as predictors of oral involvement in the presentation of acute leukemia. J Oral Med 37:38–41, 1982.PubMedGoogle Scholar
  10. 10.
    Sonis AL, Sonis ST: Gingival crevice lymphoblasts in children with acute lymphoblastic leukemia. J Periodon- tol 52:276–279, 1981.Google Scholar
  11. 11.
    Barakat NJ, Toto PD, Choukas NC: Aging and cell renewal of oral epithelium. J Periodontol, 40:599–602, 1969.PubMedGoogle Scholar
  12. 12.
    Overholser D, Peterson D, Williams L, Schimpff S: Periodontal infection in patients with acute nonlym- phocytic leukemia: Prevalence of acute exacerbation. Arch Intern Med 142:551–554, 1982.PubMedCrossRefGoogle Scholar
  13. 13.
    Dreizen S, Bodey GP, Rodriguez V: Oral complications of cancer chemotherapy. Postgrad Med 58:95–82, 1975.Google Scholar
  14. 14.
    Volger W, Huguley C, and Kerr W: Toxicity and antitumor effect of divided doses of methotrexate. Arch Intern Med. 115:285–293, 1965.Google Scholar
  15. 15.
    Archibald D: Personal Communication.Google Scholar
  16. 16.
    Thomas ED, et al.: Bone marrow transplantation. N Engl J Med 292:895–902, 1975.PubMedCrossRefGoogle Scholar
  17. 17.
    Brown LR, Dreizen S, Bodey GP: Effect of immunosuppression on the human oral flora. In Comparative Immunology of the Oral Cavity, Mergenhagen, SE Scherp HW (eds), DHEW Publication (NIH) 73–438,1973, pp. 204–220.Google Scholar
  18. 18.
    Sale GE, Shulman HM, Schubert MM, Sullivan KM, Kopecky KJ, Hackman RC, Morton TH, Szorb R, Thomas ED: Oral and ophthalmic pathology of graft versus host disease in man: predictive value of the lip biopsy. Hum Pathol 12:1022–1030, 1981.PubMedCrossRefGoogle Scholar
  19. 19.
    Shklar G: The effect of 4-amino-N10-methyl-pterogl-glutamine acid on oral mucosa of experimental animals. J Oral Ther Pharmacol 4:374–377, 1968.PubMedGoogle Scholar
  20. 20.
    Lockhart PB, Sonis ST: Alterations in the oral mucosa caused by chemotherapeutic agents. J Dermatol Surg Oncol 7:1019–1025, 1981.PubMedGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, The Hague/Boston/London 1983

Authors and Affiliations

  • Stephen T. Sonis

There are no affiliations available

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