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Inhibition of Nucleoside Transport

  • Alan R. P. Paterson
  • Ewa S. Jakobs
  • Eric R. Harley
  • Nai-Wu Fu
  • Morris J. Robins
  • Carol E. Cass
Part of the Developments in Pharmacology book series (DIPH, volume 2)

Abstract

In many types of animal cells, the movement of nucleoside molecules across the plasma membrane is a specific, transporter-mediated process [1, 2]. The existence of the nucleoside transport mechanism has been recognized from the kinetic properties of nucleoside fluxes, but nucleoside transporter elements of the plasma membrane have not yet been visualized or isolated, and their properties have only been studied indirectly. The potent, tightly bound inhibitor of nucleoside transport, nitrobenzylthioinosine (NBMPR),1 has been a valuable probe of transporter function and biology, enabling, for example, quantitation of transporter elements on cells [3] and providing an approach to their isolation from plasma membrane preparations [4]. This chapter discusses the nucleoside transport-inhibitory properties of NBMPR, N6-nitrobenzyldeoxyadenosine, and certain of their congeners, and of dilazep, a coronary vasodilator.

Keywords

Ehrlich Ascites Carcinoma Nucleoside Transport Adenosine Transport Adenosine Uptake Adenosine Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishers, The Hague 1983

Authors and Affiliations

  • Alan R. P. Paterson
  • Ewa S. Jakobs
  • Eric R. Harley
  • Nai-Wu Fu
  • Morris J. Robins
  • Carol E. Cass

There are no affiliations available

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