Animal Models for Cancer Chemotherapy

  • Abraham Goldin
Part of the Cancer Treatment and Research book series (CTAR, volume 7)


A primary purpose for the employment of animal models in cancer chemotherapy is to identify compounds, either synthetic or derived from natural products, which will be active in the clinic. The features of a comprehensive preclinical chemotherapy program designed to introduce compounds into the clinic may be summarized as follows [1–8]:
  1. a)

    Procurement, preparation and synthesis of chemical agents, fermentation and plant products, animal products and other types of materials of diverse origin. The materials for screening may be chosen on a wholly random basis or they may have as their basis some rational approach, including structure–activity analyses for classes of compounds with demonstrated antitumor properties.

  2. b)

    Screening and evaluation of these agents in experimental systems for anticancer activity and recommendation of new agents for clinical trial.

  3. c)

    Study of the toxicological and pharmacological effects of new agents in animals to permit their introduction and evaluation in man with the greatest degree of safety and effectiveness.

  4. d)

    Development and application of new and improved laboratory methods for evaluating antitumor agents.

  5. e)

    Study of the mechanism of action of drugs with clinical potential.

  6. f)

    Fundamental studies to develop new approaches that may be applied to improve chemotherapy in man.

  7. g)

    Evaluation of new agents in the clinic with recommendations concerning optimal application and modalities of therapy.



Lewis Lung Carcinoma Cytosine Arabinoside Tumor Cell Resistance Cytosine Arabinoside Therapeutic Synergism 
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© Martinus Nijhoff Publishers, The Hague 1983

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  • Abraham Goldin

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