Genetic Diversity of Bunyaviruses and Mechanisms of Genetic Variation
The family Bunyaviridae currently includes more than two-hundred arthropod-borne viruses which share certain morphological or biochemical characteristics (1). Some of these viruses can infect the central nervous system or cause haemorrhagic fever in man and other animals. The viruses are generally spherical, 80-110 nm in diameter, and contain three nelical nucleocapsids. The genome comprises three segments of single-stranded negative sense RNA designated L (large), M (medium) and S (small). For most bunyaviruses the genome encodes at least 4 proteins, including the major virion components which are the nucleocapsid protein N and the two surface glycoproteins G1 and G2. A minor large molecular weight protein designated L is sometimes observed, and this protein is presumed to be the virion transcriptase. The maturation of bunyaviruses occurs at smooth membrane vesicles, predominantly in membranes associated with the Golgi apparatus.
KeywordsSerogroup Virus Batai Virus Terminal Nucleotide Sequence California Encephalitis Bunyamwera Virus
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- 2.Smithburn, K.C., Haddow, A.J. and Mahaffay, A.F. 1946. A neurotrophic virus isolated from Aedes mosquitoes caught in the Semliki forest. Am. J. Trop. Med. 26; 184–208.Google Scholar
- 3.Main, A.J., Downs, W.G., Shope, R.E. and Wallis, R.C. 1976. Avalon and Clo Mor; two new Sakhalin group viruses from the North Atlantic. J. Med. Ent. 13; 309–315.Google Scholar
- 7.Bishop, D.H.L. 1979. Genetic potential of bunyaviruses. Curr. Topics in Microbiol, and Immunol. 86; 1–33.Google Scholar
- 8.Bishop, D.H.L., Clerx, J.P.M., Clerx-Van Haaster, C.M., Robeson, G., Rozhon, E.J., Ushijima, H. and Veerisetty, V. 1981. Molecular and genetic properties of members of the Bunyaviridae. Pp 135–146. In Bishop, D.H.L. and Compans, R,W,(eds), The Replication of Negative Strand Viruses. Elsevier/North Holland. New York and Amsterdam.Google Scholar
- 13.Bishop, D.H.L. and Gentsch, J.R. 1980. The recombination potential of bunyaviruses. Pp 81-96. In Vesenjak, J. etal.(eds), Arboviruses in Mediterranean Countries. Zbl. Bakt. Suppl. 9. Gustav Fisher Verlag. Stuttgart and New York.Google Scholar
- 14.Hunt, A.R. and Calisher, C.H. 1979. Relationships of Bunyamwera group virus by neutralisation. Am. J. Trop. Med. Hyg. 28; 740–749.Google Scholar
- 16.Faulkner-Valle, G.P., Lewis, J., Pedley, S. and McCrae, M.A. 1983. Isolation and characterisation of ts mutatns of a bovine rotavirus. In Bishop, D.H.L. and Compans, R.W., Double-stranded RNA viruses. (In press).Google Scholar
- 18.Cash, P., Vezza, A.C., Gentsch, J.R. and Bishop, D.H.L. 1979. Genome complexities of the three mRNA species of snowshoe hare bunyavirus and in vitro translation of S mRNA to viral N polypeptide. J. Virol. 31; 685–694.Google Scholar