Genetic Diversity of Bunyaviruses and Mechanisms of Genetic Variation
The family Bunyaviridae currently includes more than two-hundred arthropod-borne viruses which share certain morphological or biochemical characteristics (1). Some of these viruses can infect the central nervous system or cause haemorrhagic fever in man and other animals. The viruses are generally spherical, 80-110 nm in diameter, and contain three nelical nucleocapsids. The genome comprises three segments of single-stranded negative sense RNA designated L (large), M (medium) and S (small). For most bunyaviruses the genome encodes at least 4 proteins, including the major virion components which are the nucleocapsid protein N and the two surface glycoproteins G1 and G2. A minor large molecular weight protein designated L is sometimes observed, and this protein is presumed to be the virion transcriptase. The maturation of bunyaviruses occurs at smooth membrane vesicles, predominantly in membranes associated with the Golgi apparatus.
KeywordsRecombination Polypeptide Trop Eurasia Glyco
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