Abstract
The initial events in infection by influenza virus involve binding of virus to sialic acid residues of glycosylated membrane receptors, endocytosis, and fusion of the membranes of virus and endosome. Virus adsorption has been known for some time to be a property of the haemagglutinin glycoprotein (HA) of the virus membrane and the recent direct implication of HA in membrane fusion (1) confirms previous conclusions from a variety of observations that HA is also involved in this activity (2,3). As a consequence of these functions and of its location in the virus membrane, antibodies which affect HA neutralize virus infectivity and the frequent epidemics of influenza are caused by viruses with antigenically novel HAs.
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© 1984 Martinus Nijhoff Publishing, Boston
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Skehel, J.J. et al. (1984). Studies on the Structure and Activities of Influenza Virus Haemagglutinin. In: Kohn, A., Fuchs, P. (eds) Mechanisms of Viral Pathogenesis. Developments in Molecular Virology, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3894-9_18
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DOI: https://doi.org/10.1007/978-1-4613-3894-9_18
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