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A Review of Evidence that the Feline Leukemia Virus (FeLV) might be causative in Childhood Acute Lymphocytic Leukemia (ALL)

  • Chapter
Adrenal and Endocrine Tumors in Children

Part of the book series: Cancer Treatment and Research ((CTAR,volume 17))

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Abstract

Approximately 40% of childhood cancer is acute leukemia and non-Hodgkin lymphoma [1,2], and nearly 85% of all childhood leukemia in the United States and Europe is acute lymphocytic leukemia (ALL) [2, 3]. ALL is of worldwide distribution, and everywhere it tends to be predominantly a disease of children, with most patients being under ten years of age [3–7]. According to the Third National Cancer Survey [8], the average incidence rate in the United States for ALL in children ages 0–14 years is 2.4 per 100,000. In the United States there is no significant regional variation in the incidence of ALL. Nevertheless, the northern region has the lowest incidence rate (1.8/100,000), whereas the southern and western regions of the country share the highest incidence rate (2.9/100,000). The same survey showed a higher incidence rate (2.7/100,000) in males than in females (2.0/100,000) [8]. Most studies have reported a lower incidence of ALL in American blacks [8–11]. Childhood ALL has a peak incidence at about four years of age in white children [3, 8, 12]. Interestingly, American blacks have a different age of peak incidence, 10–14 years of age [8]. In the United States, it has been documented that the frequency of leukemia is more closely associated with socio-economic status than ethnic group [9]. As the socio-economic status increases, the frequency of ALL rises accordingly [13].

This investigation was supported by grants number CA09128 and CA-25408, awarded by the National Cancer Institute, DHEW

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Authors
  1. Glen E. Malone
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  2. Jeffrey Roseman
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  3. William M. Crist
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  4. Ronald T. Acton
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Editor information

Editors and Affiliations

  1. Department of Pediatrics, Hematology-Oncology Oklahoma Children’s Memorial Hospital, University of Oklahoma Health Sciences Center, P.O. Box 26307, Oklahoma City, OK, 73126, USA

    G. Bennett Humphrey M.D., Ph.D.

  2. Department M-305, Lilly Research Laboratories, 307 E. McCarty Street, Indianapolis, IN, 46285, USA

    Gerald B. Grindey

  3. Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Box 609, Mayo Memorial Building, Minneapolis, MN, 55455, USA

    Louis P. Dehner

  4. Diabetes Research Hospital, University of Alabama in Birmingham, Room 817 1808 7th Avenue, South Brimingham, AL, 35233, USA

    Ronald T. Acton Ph.D.

  5. Department of Pathology Oklahoma Children’s Memorial Hospital, University of Oklahoma Health Sciences Center, P.O. Box 26307, Oklahoma City, OK, 73126, USA

    Theodore J. Pysher

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© 1983 Martinus Nijhoff Publishers, Boston

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Malone, G.E., Roseman, J., Crist, W.M., Acton, R.T. (1983). A Review of Evidence that the Feline Leukemia Virus (FeLV) might be causative in Childhood Acute Lymphocytic Leukemia (ALL). In: Humphrey, G.B., Grindey, G.B., Dehner, L.P., Acton, R.T., Pysher, T.J. (eds) Adrenal and Endocrine Tumors in Children. Cancer Treatment and Research, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3891-8_3

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  • DOI: https://doi.org/10.1007/978-1-4613-3891-8_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3893-2

  • Online ISBN: 978-1-4613-3891-8

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