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Functioning Adrenocortical Tumors in Childhood

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Adrenal and Endocrine Tumors in Children

Part of the book series: Cancer Treatment and Research ((CTAR,volume 17))

Abstract

Neoplasms of the adrenal cortex are rare during childhood [1]. Their presentation is often a dramatic example of the effects of steroid over-production. The diagnosis is usually suspected in a child who manifests signs of adrenocortical hyperfunction, such as virilization, sexual precocity or Cushing’s syndrome.

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References

  1. Stewart DR, Morris-Jones PH, Jolleys A: Carcinoma of the adrenal gland in children. J Pediatr Surg 9: 59–67, 1974.

    Article  PubMed  CAS  Google Scholar 

  2. Young JL, Miller RW: Incidence of malignant tumors in U.S. children. J Pediatr 86: 254–258, 1975.

    Article  PubMed  Google Scholar 

  3. Marigo C, Muller H, Davies JNP: Survey of cancer in children admitted to a Brazilian charity hospital. J Nat Cancer Inst 43: 1231–1240, 1969.

    PubMed  CAS  Google Scholar 

  4. Hayles AB, Hahn HB, Sprague RG, Bahn RC, Priestley JT: Hormone-secreting tumors of the adrenal cortex in children. Pediatrics 37: 19–25, 1966.

    PubMed  CAS  Google Scholar 

  5. Zaitoon MM, Mackie GG: Adrenal cortical tumors in children. Urology 12: 645–649, 1978.

    Article  PubMed  CAS  Google Scholar 

  6. Kenny FM, Hashida Y, Askari A, Sieber WH, Fetterman GH: Virilizing tumors of the adrenal cortex. Am J Dis Child 115: 445–458, 1968.

    PubMed  CAS  Google Scholar 

  7. Mahloudji M, Ronaghy H, Dutz W: Virilizing adrenal carcinoma in 2 siblings. J Med Genet 8: 160–163, 1971.

    Article  PubMed  CAS  Google Scholar 

  8. Fraumeni JF, Miller RW: Adrenal cortical neoplasms and hemihypertrophy, brain tumors and other disorders. J Pediatr 70: 129–138, 1967.

    Article  PubMed  Google Scholar 

  9. Burr IM, Graham T, Sullivan J, Hartman WH, O’Neill J: A testosterone-secreting tumor of the adrenal producing virilization in a female infant. Lancet 2: 643–644, 1973.

    Article  PubMed  CAS  Google Scholar 

  10. Schteingart DE, Woodbury MC, Tsao HS, McKenzie AK: Virilizing syndrome associated with an adrenal cortical adenoma secreting predominantly testosterone. Am J Med 67:140– 146, 1979.

    Google Scholar 

  11. Saez JM, Rivarola MA, Migeon CJ: Studies of androgens in patients with adrenocortical tumors. J Clin Endocr 27: 615–623, 1967.

    Article  PubMed  CAS  Google Scholar 

  12. Baulieu E-E: Studies of conjugated 17-ketosteroids in a case of adrenal tumor. J Clin Endocr 22: 501–510, 1962.

    Article  PubMed  CAS  Google Scholar 

  13. Gallagher TF: On alterations in adrenal function, especially with adrenocortical carcinoma. Cancer Res 17: 520–529, 1957.

    PubMed  CAS  Google Scholar 

  14. Lipsett MB, Hertz R, Ross GT: Clinical and pathophysiologic aspects of adrenocortical carcinoma. Am J Med 35: 374–383, 1963.

    Article  PubMed  CAS  Google Scholar 

  15. Lipsett MB, Wilson H: Adrenocortical cancer: Steroid biosynthesis and metabolism evaluated by urinary metabolites. J Clin Endocr Metab 22: 906–915, 1962.

    Article  PubMed  CAS  Google Scholar 

  16. Guin GH, Gilbert EF: Cushing’s syndrome in children associated with adrenal cortical carcinoma: A case report with review of the literature. Am J Dis Child 92: 297–307, 1956.

    CAS  Google Scholar 

  17. McArthur RG, Cloutier MD, Hayles AB, Sprague RG: Cushing’s disease in children: Findings in 13 cases. Mayo Clin proc 47: 318–326, 1972.

    PubMed  CAS  Google Scholar 

  18. Eddy RL, Jones AL, Gilliland PF, Ibarra JD, Thompson JQ, McMurray JF: Cushing’s syndrome: A prospective study of diagnostic methods. Am J Med 55: 621–630, 1973.

    Article  PubMed  CAS  Google Scholar 

  19. Sultan C, Descomps B, Garandeau P, Bressot N, Jean R: Pubertal gynecomastia due to an estrogen-producing adrenal adenoma. J Pediatr 95: 744–746, 1979.

    Article  PubMed  CAS  Google Scholar 

  20. Liddle GW: Tests of pituitary-adrenal suppressibility, the diagnosis of Cushing’s syndrome. J Clin Endocr Metab 20: 1539–1560, 1960.

    Article  PubMed  CAS  Google Scholar 

  21. Kendall JW, Sloop PR: Dexamethasone suppressible adrenocortical tumor. N Eng J Med 279: 532–535, 1968.

    Article  CAS  Google Scholar 

  22. Rayfield EJ, Rose LI, Cain JP, Dluhy RG, Williams GH: ACTH–responsive, dexamethasone-suppressible adrenocortical carcinoma. N Engl J Med 284: 591–592, 1971.

    Article  PubMed  CAS  Google Scholar 

  23. Bagshawe KD: Hypokalemia, carcinoma and Cushing’s syndrome. Lancet 2: 284–287, 1960.

    Article  PubMed  CAS  Google Scholar 

  24. Boldt DW, Reilly BJ: Computed tomography of abdominal mass lesions in children. Radiology 124: 371–378, 1977.

    PubMed  CAS  Google Scholar 

  25. Beierwaltes WH, Wieland DM, Yu T, Swanson DP, Mosley ST: Adrenal imaging agents: Rational, synthesis, formulation and metabolism. Semin Nucl Med 8: 5–21, 1978.

    Article  PubMed  CAS  Google Scholar 

  26. Chatal JF, Charbonnel B, LeMevel BP, Guihard D: Uptake of 131I-19-iodocholesterol by an adrenal cortical carcinoma and its metastases. J Clin Endocr Metab 43: 248–251, 1976.

    Article  PubMed  CAS  Google Scholar 

  27. Seabold JE, Schteingart DE: I-131-iodocholesterol imaging in adrenal neoplasms. J Nucl Med 16: 566, 1975.

    Google Scholar 

  28. Sarkar SD, Beierwaltes WH, Ice RD, Basmadjian GP, Hetzel KR, Kennedy WP, Mason MM: A new and superior adrenal scanning agent, NP–59. J Nucl Med 16: 1038–1042, 1975.

    PubMed  CAS  Google Scholar 

  29. Thrall JH, Frietas JE, Beierwaltes WH: Adrenal scintigraphy Semin Nuclear Med 8: 23–41, 1978.

    Article  CAS  Google Scholar 

  30. Winter JSD: Adrenal tumors in childhood. In: Endocrine and genetic diseases of childhood and adolescence, Gardner L, (ed) WB Sanders Co, Philadelphia, 1975, p 507–513.

    Google Scholar 

  31. Hutter AM Jr, Kayhoe DE: Adrenal cortical carcinoma: Results of treatment with o,p,DDD in 138 patients. Am J Med 41: 581–592, 1966.

    Article  PubMed  Google Scholar 

  32. Schteingart DE, Cash R, Coon JW: Amino-glutethimide and metastatic adrenal cancer. JAMA 198: 1007–1010, 1966.

    Article  PubMed  CAS  Google Scholar 

  33. Hoffman MG, Mattox VR: Treatment of adrenal cortical carcinoma with o,p,DDD. Med Clin N Am 56: 999–1012, 1972.

    PubMed  CAS  Google Scholar 

  34. Percarpio B, Knowlton AH: Radiation therapy of adrenal cortical carcinoma. Acta Rad Ther 15: 288–292, 1976.

    CAS  Google Scholar 

  35. Tang CK, Gray GF: Adrenocortical neoplasms: Prognosis and morphology. Urology 5:691– 695, 1975.

    Google Scholar 

  36. Heinbecker P, O’Neal LW, Ackerman LV: Functioning and non-functioning adrenal corti¬cal tumors. Surg Gynecol Obstet 105: 21–33, 1957.

    PubMed  CAS  Google Scholar 

  37. Hough AJ, Hollifield JW, Page DL, Hartmann WH: Prognostic factors in adrenal cortical tumors. A mathematical analysis of clinical and morphologic data. Am J Clin Pathol 72: 390–399, 1979.

    PubMed  CAS  Google Scholar 

  38. Hogan TF, Gilchrist KW, Westring DW, Citrin DL: A clinical and pathologic study of adrenal cortical carcinoma. Therapeutic implications. Cancer 45: 2880–2883, 1980.

    Article  PubMed  CAS  Google Scholar 

  39. Lewinsky BS, Grigor KM, Symington T, Neville AM: The clinical and pathologic features of 4 non-hormonal’ adrenocortical tumors. Report of twenty new cases and review of the literature. Cancer 33: 778–790, 1974.

    Article  PubMed  CAS  Google Scholar 

  40. King DR, Lack EE: Adrenal cortical carcinoma. A clinical and pathologic study of 49 cases. Cancer 44: 239–244, 1979.

    Article  PubMed  CAS  Google Scholar 

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© 1983 Martinus Nijhoff Publishers, Boston

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Holcombe, J.H., Pysher, T.J., Kirkland, R.T. (1983). Functioning Adrenocortical Tumors in Childhood. In: Humphrey, G.B., Grindey, G.B., Dehner, L.P., Acton, R.T., Pysher, T.J. (eds) Adrenal and Endocrine Tumors in Children. Cancer Treatment and Research, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3891-8_12

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  • DOI: https://doi.org/10.1007/978-1-4613-3891-8_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3893-2

  • Online ISBN: 978-1-4613-3891-8

  • eBook Packages: Springer Book Archive

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