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Enzyme Induction and Modulation pp 89–109Cite as

Plasma protein induction by isolated hepatocytes

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Part of the book series: Developments in molecular and cellular biochemistry ((DMCB,volume 3))

Summary

Hepatocytes can be maintained in culture for periods of a few hours to many days. This review summarizes the metabolic characteristics of these cultures and describes their use in studying the regulation of plasma protein synthesis. Hormones selectively stimulate the synthesis of certain proteins. Cortisol stimulates the synthesis of fibrinogen and other acute-phase proteins; whereas, insulin stimulates albumin synthesis. In the latter case insulin increases the rate of a nuclear process. Mediators elaborated by leukocytes stimulate acute-phase protein synthesis in hepatocytes. Plasmin-generated fibrin peptides stimulate fibrinogen synthesis via a leukocytic mediator. Lipoprotein synthesis is stimulated by fatty acids and is inhibited by albumin and other macromolecules. These and other processes are susceptible to detailed analysis using sub-cellular fractions (mRNA, nuclei, transcription factors, etc.) isolated from hepatocytes. Studies on fetal or embryonic hepatocytes and hepatomas are yielding information on the regulation of secretory protein synthesis during development and following neoplastic transformation.

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Authors and Affiliations

  1. Research Dept. J. T. Baker Chemical Co., Phillipsburg, N.J., 08865, USA

    Laura J. Crane

  2. New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, N.Y., 10314, USA

    David L. Miller

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  1. Laura J. Crane
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  1. Division of Protein Chemistry, Tufts University School of Medicine, Boston, Massachusetts, USA

    V. A. Najjar

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Crane, L.J., Miller, D.L. (1983). Plasma protein induction by isolated hepatocytes. In: Najjar, V.A. (eds) Enzyme Induction and Modulation. Developments in molecular and cellular biochemistry, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3879-6_6

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  • DOI: https://doi.org/10.1007/978-1-4613-3879-6_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3881-9

  • Online ISBN: 978-1-4613-3879-6

  • eBook Packages: Springer Book Archive

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