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Modulation of poly(A)(+)mRNA-metabolizing and transporting systems under special consideration of microtubule protein and actin

  • Werner E. G. Müller
  • August Bernd
  • Heinz C. Schröder
Part of the Developments in molecular and cellular biochemistry book series (DMCB, volume 3)

Summary

At present, three enzymes are known which participate in regulation of polyadenylation and polydeadenylation of eukaryotic mRNA: poly(A) polymerase, endoribonucleaselV and2‘,3’-exoribonuclease. Moreover, poly(A)-associated proteins as well as the cytoskeletal proteins actin and tubulin have been found to be involved in poly(A) metabolism of mRNA; their modulation effects on poly(A) metabolizing enzyme systems will be described in greater detail. Nucleocytoplasmic transport of poly(A)-containing mRNA is thought to be mediated by nuclear-envelope nucleoside triphosphatase. The stimulation of this enzyme by the poly(A) segment of mRNA and its modulation by microtubule protein are discussed in the second part of this review.

Keywords

Nuclear Matrix Nuclear Pore Complex Catabolic Enzyme Nucleocytoplasmic Transport Tubulin Dimer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishers, Boston 1983

Authors and Affiliations

  • Werner E. G. Müller
    • 1
  • August Bernd
    • 1
  • Heinz C. Schröder
    • 1
  1. 1.Institut für Physiologische Chemie, Abteilung “Angewandte Molekularbiologie”Universität, DuesbergwegMainzGermany

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