Adaptation of the Kidney to Extrauterine Life

  • J.-P. Guignard
Part of the Developments in Nephrology book series (DINE, volume 6)


The fetal kidney does not carry excretory responsibilities. Urine formation is however present from the 9–12th week of gestation, and increases progressively throughout gestation to reach 28 ml/h shortly before birth (Fig.1) Fetal urine is the major constituent of amniotic fluid.


Glomerular Filtration Rate Premature Infant Newborn Infant Premature Neonate Effective Renal Plasma Flow 
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  1. 1.
    Campbell S., Wladimiroff J.W. and Dewhurst C.J.: The antenatal measurement of fetal urine production. J. Obstet.Gynaec.Brit.Cwlth. 80: 680, 1973.CrossRefGoogle Scholar
  2. 2.
    Schulz D.M., Giordano D.A., and Schulz D.H.: Weights of organs of fetuses and infants. Arch.Pathol. 74: 244, 1962.PubMedGoogle Scholar
  3. 3.
    Fawer C.L., Torrado A. and Guignard J.-P.: Maturation of renal function in full-term and premature neonates. Helv. Paediat.Acta 34: 11, 1979.PubMedGoogle Scholar
  4. 4.
    Guignard J.-P., Torrado A., Da Cunha O. and Gautier E.: Renal function in respiratory distress syndrome J.Pediat. 88: 845, 1976.Google Scholar
  5. 5.
    Guignard J.-P., Torrado A., Da Cunha O. and Gautier E.: Glomerular filtration rate in the first three weeks of life. J.Pediat. 87: 268, 1975.PubMedCrossRefGoogle Scholar
  6. 6.
    Strauss J., Daniel S.S. and James L.S.: Postnatal adjustment in renal function. Pediatrics 68: 802, 1981.PubMedGoogle Scholar
  7. 7.
    Svenningsen N.W.: Single injection polyfructosan clearance in normal and asphyxiated neonates. Acta Paediat.Scand. 64: 87, 1975.PubMedCrossRefGoogle Scholar
  8. 8.
    Feldman H. and Guignard J.-P.: Plasma creatinine in the first month of life. Arch.Dis.Child. 57: 123, 1982.PubMedCrossRefGoogle Scholar
  9. 9.
    Gruskin A.B., Edelmann C.M. and Yvan S.: Maturational changes in renal blood flow in piglets. Pediatr.Res. 4: 7, 1970.PubMedGoogle Scholar
  10. 10.
    Larson L. and Maunsbach A.B.: Correlation between glomerular ultrastructure and function during the development of the rat kidney. Int.J.Ped.Nephrol. 1: 246, 1980.Google Scholar
  11. 11.
    Edelman C.M.,jr., Barnett H.L. and Troupkov V.: Renal concentrating mechanisms in newborn infants: effect of dietary protein and water content, role of urea, and responsiveness to antidiuretic hormone. J.Clin. Invest. 39: 1062, 1960.CrossRefGoogle Scholar
  12. 12.
    Joppich R., Scherer B. and Weber P.C.: Renal prostablandins: relationship to the development of blood pressure and concentrating capacity in pre-term and full-term healthy infants. Europ.J.Pediat.: 132: 253, 1979.PubMedCrossRefGoogle Scholar
  13. 13.
    Gruskin A.B., Oetliker O.H., Wolfish N.M. et al: Effects of angiography on renal function and histology in infants and piglets. J.Pediatr. 76: 41, 1970.PubMedCrossRefGoogle Scholar
  14. 14.
    Avner E.D., Ellis D., Jaffe R et al: Neonatal radiocontrast nephropathy simulating infantile polycystic kidney disease. J.Pediat. 100: 85, 1982.PubMedCrossRefGoogle Scholar
  15. 15.
    Torrado A., Guignard J.-P., Prodhom L.S. et al: Hypoxemia and renal function in newborns with respiratory distress syndrome. Helv. Paediat.Acta 29: 399, 1974.PubMedGoogle Scholar
  16. 16.
    Leake R.D., Zakaudin S., Trygstad C.W. et al: The effects of large volume intravenous fluid infusion on neonatal renal functions. J.Pediat. 89: 968, 1976.PubMedCrossRefGoogle Scholar
  17. 17.
    Schwartz G.J., Haycock G.B., Edelman C.M, Jr et al: Late metabolic acidosis: a reassessment of the definition. J. Pediat. 95: 102, 1979.PubMedCrossRefGoogle Scholar
  18. 18.
    Svenningsen N.W.: Renal acid base titration studies in infants with and without metabolic acidosis in the postneonatal period. Pediat.Res. 8: 659, 1974.PubMedGoogle Scholar
  19. 19.
    Aperia A., Broberger O., Thodenius K. and Zetterström R.: Renal response to an oral sodium load in newborn full term infants. Acta Paediat. Scand. 61: 670, 1972.Google Scholar
  20. 20.
    Merlet-Benichou C. and de Rouffignac C.: Renal clearance studies in fetal and young guinea-pigs: effect of sodium loading. Am.J.Physiol. 232: F178, 1977.PubMedGoogle Scholar
  21. 21.
    Sulyok E., Németh M., Tényi I. et al: Postnatal development of renin-angiotensin-aldosterone system, RAAS, in relation to electrolyte balance in premature infants. Pediat.Res. 13: 817, 1979.PubMedGoogle Scholar
  22. 22.
    Aperia A., Broberger O., Herin P. and Zetterström R-: Sodium excretion in relation to sodium intake and aldosterone excretion in newborn pre-term and full-term infants. Acta Paediat.Scand. 68: 1, 1979.CrossRefGoogle Scholar
  23. 23.
    Roy R.N., Chance G.W., Radde I.C. et al: Late hyponatremia in very low-birth-weight infants. Pediat.Res. 10: 526, 1976.PubMedCrossRefGoogle Scholar
  24. 24.
    Kotchen T.A., Strickland A.L., Rice T.W. et al: A study of the renin-angiotensin system in newborn infants J. Pediat. 80: 938, 1972.PubMedCrossRefGoogle Scholar
  25. 25.
    Guignard J.-P., Burgener F. and Calame A.: Persistent anuria in a neonate: a side effect of captopril ? Internat.J.Ped.Nephrol. 2: 133, 1981.Google Scholar
  26. 26.
    Dauber I.M., Krauss A.N., Symchych P.S. et al: Renal failure following perinatal anoxia. J.Pediat. 88: 851, 1976.PubMedCrossRefGoogle Scholar
  27. 27.
    Broughton-Pipkin F. and Smales O.R.C.: A study of factors affecting blood pressure and angiotensin II in newborn infants. J.Pediat. 91: 113, 1977.PubMedCrossRefGoogle Scholar
  28. 28.
    Guignard J.-P. and Filloux B.: Pathophysiologic renal changes during hypoxemia in the rabbit. Kidney Internat. 15: 585, 1979.Google Scholar
  29. 29.
    Guignard J.-P., Wallimann C. and Gautier E.: Prevention by verapamil of the hypoxemia-induced renal vasoconstriction. Kidney Internat. 20: 139, 1981.Google Scholar
  30. 30.
    Robillard J.E., Weitzman R.E., Burmeister L. et al: Developmental aspects of the renal response to hypoxemia in the lamb-fetus. Circ.Res. 48: 128, 1981.PubMedGoogle Scholar
  31. 31.
    Fewell J.E. and Norton J.B.: Continuous positive airway pressure impairs renal function in newborn goats. Pediat.Res. 14: 1132, 1980.PubMedCrossRefGoogle Scholar
  32. 32.
    Marquez J.M., Douglas M.E., Downs J.B. et al. Renal function and cardiovascular responses during positive airway pressure. Anesthesiology 50: 393, 1979,Google Scholar
  33. 33.
    Moore E.S., Galvez M.B., Paton J.B. et al: Effect of positive pressure ventilation on intrarenal blood flow in infant primates. Pediat.Res. 8: 792, 1974.PubMedGoogle Scholar
  34. 34.
    Guignard J.-P., Filloux B., Lavoie J. et al: Effect of intravenous diazepam on renal function. Clin.Pharm. Ther. 18: 401, 1975.Google Scholar
  35. 35.
    Catterton Z., Sellers B. and Gray B.: inulin clearance in the premature infant receiving indomethacin. J.Pediat. 96: 737, 1980.PubMedCrossRefGoogle Scholar
  36. 36.
    Cifuentes R.F., Olley P.M., Balfe J.W. et al.: Indomethacin and renal failure function in premature infants with persistent patent ductus arteriosus. J.Pediat. 95: 583, 1979.PubMedCrossRefGoogle Scholar
  37. 37.
    Goetzman B.W., Sunshine P., Johnson J.D. et al: Neonatal hypoxia and pulmonary vasospasm: response to tolazoline. J.Pediat. 89: 617, 1976.PubMedCrossRefGoogle Scholar
  38. 38.
    Naujoks S. and Guignard J.-P.: Renal effects of tolazoline in rabbits. Lancet 2: 1075, 1979.PubMedCrossRefGoogle Scholar
  39. 39.
    Adelman R.D. and Zakauddin S.: Urinary enzyme activities in children and neonates receiving gentamicin therapy. Dev.Pharmacol.Ther. 1: 325, 1980.Google Scholar
  40. 40.
    Wilson G., Tabin R., Micheli J.L. and Guignard J.-P.: Creatinine clearance studies in newborn infants receiving gentamicin. Kidney Internat. 1982, in press.Google Scholar

Copyright information

© Martinus Nijhoff Publishers, Boston 1983

Authors and Affiliations

  • J.-P. Guignard
    • 1
  1. 1.Service de PédiatrieCHUVLausanneSwitzerland

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