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Fine structural features of Sertoli cells

  • Leif Plöen
  • E. Martin Ritzén
Part of the Electron Microscopy in Biology and Medicine book series (EMBM, volume 2)

Abstract

The Sertoli cell may be defined as, ‘a somatic cell associated individually and simultaneously with several generations of germ cells’ (30). In 1865, Sertoli (37) described these cells as ‘celluli ramificato’ and since 1888 (6) they have borne his name. Attempts have been made to introduce other names — sustentacular cells or sustenocytes, supporting cells, nurse cells — but the name Sertoli cells is generally accepted today.

Keywords

Sertoli Cell Seminiferous Tubule Seminiferous Epithelium Ectoplasmic Specialization Sertoli Cell Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Andersen K, Sundby A, Hansson V: Fine structure and FSH binding of Sertoli cells in the blue fox (Alopex lagopus) in different stages of reproductive activity. Int J Androl (4): 570–581, 1981.PubMedCrossRefGoogle Scholar
  2. 2.
    Armstrong DT, Dorrington JH: Estrogen biosynthesis in the ovaries and testes. In: Advances in sex hormone research. Regulatory mechanisms affecting gonadal hormone action. Thomas JA, Singhai RL (eds). Baltimore. University Park Press, 1977, pp 217–258.Google Scholar
  3. 3.
    Boitani C, Ritzen EM, Parvinen M: Inhibition of rat Sertoli aromatase by factor(s) secreted specifically at spermatogenic stages VII and VIII. Mol Cell Endocrinol (23): 11–22, 1981.PubMedCrossRefGoogle Scholar
  4. 4.
    Dym M: The fine structure of the monkey (Macacca) Sertoli cell and its role in maintaining the blood-testis barrier. Anat Rec (175): 639–656, 1973.PubMedCrossRefGoogle Scholar
  5. 5.
    Dym M, Fawcett DW: The blood-testis barrier in the rat and the physiological compartmentation of the seminiferous epithelium. Biol Reprod (3): 308–326, 1970.PubMedGoogle Scholar
  6. 6.
    von Ebner V: Zur Spermatogenese bei den Säugetieren. Arch, mikrosk. Anat (31): 236–292, 1888.CrossRefGoogle Scholar
  7. 7.
    Fawcett DW: Ultrastructure and function of the Sertoli cell. In: Handbook ofPhysiology. Hamilton DW, Greep RO (eds). Washington. American Physiological Society, 1975, pp 21–55.Google Scholar
  8. 8.
    Fawcett DW, Leak LV, Heidger PM: Electron microscopic observations on the structural components of the blood-testis barrier. J Reprod Fert suppl (10): 105–122, 1970.Google Scholar
  9. 9.
    Fawcett DW, Phillips DM: Observations on the release of spermatozoa and on changes in the head during passage through the epididymis. J Reprod Fert suppl (6): 405–418, 1969.Google Scholar
  10. 10.
    Flickinger, CJ: The postnatal development of the Sertoli cells of the mouse. Z Zellforsch (78): 9 2113, 1967.Google Scholar
  11. 11.
    Fritz IB, Rommerts FG, Louis BG, Dorrington JH: Regulation by FSH and dibutyryl cyclic AMP of the formation of adrogen-binding protein in Sertoli cellenriched cultures. J Reprod Fertil (46): 17–24, 1976.PubMedCrossRefGoogle Scholar
  12. 12.
    Gilula NB, Fawcett DW, Aoki A: The Sertoli cell occluding junctions and gap junctions in mature and developing mammalian testis. Develop Biol (50): 142–168, 1976.PubMedCrossRefGoogle Scholar
  13. 13.
    Gordeladze JO, Parvinen M, Clausen OPF, Hansson V: Stage dependent variation in Mn2 +-sensitive adenylyl cyclase (AC) activity in spermatids and FSH-sensitive AC in Sertoli cells. Arch Androl (8): 43–51, 1982.PubMedCrossRefGoogle Scholar
  14. 14.
    Hagenäs L, Ritzen EM, Plöen L, Hansson V, French FS, Nayfeh SN: Sertoli cell origin of testicular androgen-binding protein (ABP). Mol Cell Endocrinol (2): 339–350, 1975.PubMedCrossRefGoogle Scholar
  15. 15.
    Hagenäs L, Plöen L, Ekwall H, Osman DI, Ritzen EM: Differentiation of the rat seminiferous tubules between 13 and 19 days of age. Int J Androl (4): 257–264, 1981.PubMedCrossRefGoogle Scholar
  16. 16.
    Kerr JB, de Kretser DM: Cyclic variations in Sertoli cell lipid content throughout the spermatogenic cycle in the rat. J Reprod Fert (43): 1–8, 1975.CrossRefGoogle Scholar
  17. 17.
    Kierszenbaum AL: Distribution of newly synthesized proteins in Sertoli cells as traced by electron microscope autoradiography. In: The testis in normal and infertile men. Troen P, Nankin HR (eds), New York. Raven Press, 1977, pp 125–136.Google Scholar
  18. 18.
    Lacroix M, Parvinen M, Fritz IB: Localization of testicular plasminogen activator in descrete portions (Stages VII and VIII) of the seminiferous tubule. Biol Reprod (25): 143–146, 1981.PubMedCrossRefGoogle Scholar
  19. 19.
    Meyer R, Posalaky Z, McGinley D: Intercellular junction development in maturing rat seminiferous tubules. J Ultrastruct Res (61): 271–283, 1977.PubMedCrossRefGoogle Scholar
  20. 20.
    Van der Molen HJ, Grootegoed JA, de Greef-Biljeveld MJ, Rommerts FFG, van der Vusse GJ: Distribution of steroids, steroid production and steroid metabolizing enzymes in rat testis. In: Hormonal regulation of spermatogenesis. French FS, Hansson V, Ritzen EM, Nayfeh SN (eds), New York. Plenum Press, 1975, pp 3–23.Google Scholar
  21. 21.
    Nagano T, Suzuki F: Freeze-fracture observations on the intercellular junctions of Sertoli cells and of Leydig cells in the human testis. Cell Tiss Res (166): 37–48, 1976.CrossRefGoogle Scholar
  22. 22.
    Nicander L: An electron microscopical study of cell contacts in the seminiferous tubules of some mammals, Z Zellforsch (83): 375–397, 1967.PubMedCrossRefGoogle Scholar
  23. 23.
    Osman DI, Plöen L: The ultrastructure of Sertoli cells in the boar. Int J Androl (1): 162–179, 1978.CrossRefGoogle Scholar
  24. 24.
    Parvinen M, Marana R, Robertson DM, Hansson V, Ritzen EM: Functional cycle of rat Sertoli cells: Differential binding and action of FSH at various stages of the spermatogenic cycle. In: Testicular Development Structure, and Function. Steinberger A, Steinberger E (eds). New York. Raven Press, 1980, pp 423–432.Google Scholar
  25. 25.
    Purvis K, Hansson V: Hormonal regulation of spermatogenesis: Regulation of target cell response. Int J Androl (suppl 3): 81–143, 1981.Google Scholar
  26. 26.
    Rambourg A, Clermont Y, Marraud A: Three-dimensional structure of the osmium-impregnated Golgi Apparatus as seen in the high voltage electron microscope, Am J Anat (140): 27–46, 1974.PubMedCrossRefGoogle Scholar
  27. 27.
    Ritzen EM,HanssonV,FrenchFS: The Sertoli cell. In: The Testis. BurgerH,deKretserD (eds) New York. Raven Press, 1981, pp 171–194Google Scholar
  28. 28.
    Ritzen EM, Boitani C, Parvinen M, French FC, Feldman M: Stage-dependent secretion of ABP by rat seminiferous tubules. Mol Cell Endocrinol (25): 25–33, 1982.PubMedCrossRefGoogle Scholar
  29. 29.
    Roosen-Runge EC: The process of spermatogenesis in mammals. Biological reviews (37): 343–377, 1962.PubMedCrossRefGoogle Scholar
  30. 30.
    Roosen-Runge E: The process of spermatogenesis in animals. Developmental and cell biology 5. Cambridge University Press, 1977.Google Scholar
  31. 31.
    Ross MH: The Sertoli cell junctional specialization during spermio-genesis and at spermiation. Anat Rec (186): 79–104, 1976.CrossRefGoogle Scholar
  32. 32.
    Russel L: Desmosome-like junctions between Sertoli and germ cells in the rat testis. Am J Anat (148): 301–312, 1977.CrossRefGoogle Scholar
  33. 33.
    Russel L: Movement of spermatocytes from the basal to the adluminal compartment of the rat testis. Am J Anat (148): 313–328, 1977.CrossRefGoogle Scholar
  34. 34.
    Russel L: Spermatid-Sertoli tubulobulbar complexes as devices for elimination of cytoplasm from the head region of late spermatids of the rat. Anat Rec (194): 233–246, 1979.CrossRefGoogle Scholar
  35. 35.
    Russel L, Myers P, Ostenburg J, Malone J: Sertoli ectoplasmic specializations during spermatogenesis. In: Testicular Development, Structure, and Function. Steinberger A, Steinberger E (eds), New York. Raven Press, 1980, pp 55–63.Google Scholar
  36. 36.
    Schulze C: On the morphology of the human Sertoli cell. Cell Tiss Res (153): 339–355, 1974.CrossRefGoogle Scholar
  37. 37.
    Sertoli E: Dell’esistenza de particolari cellule ramificati nei canalicoli seminiferi del testiculo humano. Morgagni (7): 31–39, 1865.Google Scholar
  38. 38.
    Setchell BP, Voglmayr JK, Waites GMH: A blood-testis barrier restricting passage from blood into rete testis fluid but not into lymph. J Physiol (200): 73–85, 1969.PubMedGoogle Scholar
  39. 39.
    Setchell BP, Waites GMH: The blood-testis barrier. In: Handbook of physiology. Hamilton DW, Greep RO (eds), Washington. American Physiological Society, 1975, pp 143–172.Google Scholar
  40. 40.
    Steinberger A, Steinberger E: The Sertoli cells. In: The testis IV. Johnson AD, Gomes WR, (eds), London. Academic Press, Inc, 1977, pp 371–399.Google Scholar
  41. 41.
    Toyama Y: Ultrastructural study of crystalloids in Sertoli cells of the normal, intersex and experimental cryptorchid swine. Cell Tiss Res (158): 205–213, 1975.CrossRefGoogle Scholar
  42. 42.
    Toyama Y: Actin-like filaments in the Sertoli cell junctional specializations in the swine and mouse testis. Anat Rec (186): 477–492, 1976.PubMedCrossRefGoogle Scholar
  43. 43.
    Tres LL, Kierszenbaum AL: Transcription during mammalian sperma-togenesis with special reference to Sertoli cells. In: Hormonal regulation of spermatogenesis. French FS, Hansson V, Ritzen EM, Nayfeh SN (eds), New York London. Plenum Press, 1975, pp 455–478.Google Scholar
  44. 44.
    Tung PS, Fritz IB: Specific surface antigens on rat pachytene spermatocytes and successive classes of germinal cells. Develop Biol (64): 297–315, 1978.PubMedCrossRefGoogle Scholar
  45. 45.
    Tung PS, Fritz IB: Histopathological changes in testes of adult inbred rats immunized against pachytene spermatocytes or Sertoli cells. Int J Androl suppl 2: 459–477, 1978.CrossRefGoogle Scholar
  46. 46.
    Vitale R, Fawcett DW, Dym M: The normal development of the blood- testis barrier and the effects of clomiphene and estrogen treatment. Anat Rec (176): 333–344, 1973.CrossRefGoogle Scholar
  47. 47.
    Yasuzumi G, Tanaka H, Tezuka O: Spermatogenesis in animals as revealed by electron microscopy. VIII. Relations between the nutritive cells and the developing spermatids in a pond snail. J Biophys Biochem Cytol (7): 499–504, 1960.PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers, Boston, The Hague, Dordrecht, Lancaster 1984

Authors and Affiliations

  • Leif Plöen
    • 1
  • E. Martin Ritzén
    • 2
  1. 1.Department of Anatomy and Histology Faculty of Veterinary MedicineSwedish University of Agricultural SciencesUppsalaSweden
  2. 2.Pediatric Endocrinology UnitKarolinska SjukhusetStockholmSweden

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