Virus-like particles and related expressions in mammalian oocytes and preimplantation stage embryos

  • Yoshio Yotsuyanagi
  • Daniel Szöllösi
Part of the Electron Microscopy in Biology and Medicine book series (EMBM, volume 2)


The presence of virus-like particles in the oocytes and preimplantation stage embryos of several species has perplexed mammalian embryologists since their occurrence was first detected by electron microscopy (1, 2). Interest in this phenomenon was renewed in the early 1970s when three laboratories independently reported the presence of particles resembling RNA tumor viruses in the early cleavage stage embryos of several strains of mice (3, 4, 5). These studies showed that virus-like particle expression was stage-specific, was not the result of exogenous infection and, in spite of relatively large numbers of particles, did not interfere with normal development. Collectively, the observations led to the conclusion that virus-like particle expression was a scheduled event in the normal developmental program of the embryo.


Transposable Element Long Terminal Repeat Natl Cancer Inst Syrian Hamster Preimplantation Embryo 
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Copyright information

© Martinus Nijhoff Publishers, Boston, The Hague, Dordrecht, Lancaster 1984

Authors and Affiliations

  • Yoshio Yotsuyanagi
    • 1
  • Daniel Szöllösi
    • 2
  1. 1.Centre de Génétique MoléculaireC.N.R.S.Gif-sur-YvetteFrance
  2. 2.Station Centrale de Physiologie AnimaleI.N.R.A.Jouy-en-JosasFrance

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