The mosaic organisation of the preimplantation mouse embryo

  • M. H. Johnson
  • C. A. Ziomek
  • W. J. D. Reeve
  • H. P. M. Pratt
  • H. Goodall
  • A. H. Handyside
Part of the Electron Microscopy in Biology and Medicine book series (EMBM, volume 2)

Abstract

The formation of the inner cell mass (ICM) and trophectoderm of the blastocyst constitutes the first definitive spatial differentiation of cells during embryogenesis. The two tissues show differences in structure, function, biochemistry, prospective fate and developmental potency. An understanding of the origins of these cell subpopulations, and the mechanism by which they are generated during cleavage, has proved to be elusive. It has been agreed generally that whatever mechanism operates, it must accommodate the prodigious regulatory capacity of the cells of the cleaving embryo, the morula and even the early blastocyst itself. Whilst this prolonged period of developmental lability apparently places the mammalian embryo in a unique position, it has also led frequently to the erroneous conclusion that the underlying mechanisms operating within the embryo must be correspondingly unique. Thus, embryos of many lower vertebrates and invertebrates appear to be mosaics, in which spatial differences in the cytoplasmic organisation within the individual egg, zygote or early blastomere are translated by cell divisions into regional differences among the cells of the embryo.

Keywords

Permeability Compaction Fluorescein Thymidine FITC 

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Copyright information

© Martinus Nijhoff Publishers, Boston, The Hague, Dordrecht, Lancaster 1984

Authors and Affiliations

  • M. H. Johnson
    • 1
  • C. A. Ziomek
    • 1
  • W. J. D. Reeve
    • 1
  • H. P. M. Pratt
    • 1
  • H. Goodall
    • 1
  • A. H. Handyside
    • 1
  1. 1.Department of AnatomyCambridgeUK

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