Skip to main content
SpringerLink
Log in
Book cover

Gynecologic Oncology pp 155–186Cite as

Treatment of Advanced Trophoblastic Disease

  • Chapter

Part of the book series: Cancer Treatment and Research ((CTAR,volume 10))

Abstract

Knowledge of the diverse behaviour of trophoblastic tumours has increased greatly over the 25 years since the introduction of methotrexate [1] and methods of treatment have developed accordingly. The best possible management of the individual patient now involves complex considerations leading to treatment chosen according to the particular characteristics of the patient and her tumour. This has been achieved by sustained work in a limited number of specialized centres but in spite of the advances some of these young women still die. Many of the deaths can be attributed to inappropriate treatment started in centres lacking experience in this group of diseases. There remains a strong case for the continued referral of patients to units where experience has accumulated and where old lessons do not have to be re-learned.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Li MC, Hertz R, Spencer DB: The effect of methotrexate therapy upon choriocarcinoma and chorioadenoma. Proc Soc exp Biol (NY) 93:361–366, 1956.

    Google Scholar 

  2. Kajii T, Ohama K: Androgenetic origin of hydatidiform mole. Nature 268:633–634, 1977.

    Article  PubMed  CAS  Google Scholar 

  3. Kurman RJ, Scully RE, Norris HJ: Trophoblastic pseudotumor of the uterus. An exaggerated form of ‘syncytial endometritis’ simulating a malignant tumor. Cancer 38:1214–1226, 1976.

    Article  PubMed  CAS  Google Scholar 

  4. Goldstein DP: Prevention of gestational trophoblastic disease by use of actinomycin-D in molar pregnancies. J Obstet Gynecol 43:475–479, 1974.

    CAS  Google Scholar 

  5. Hatch KD, Shingleton HM, Austin JM, Boots LR, Younger JB, Soong SJ: Southern regional trophoblastic disease centre, 1972–1977. Southern Med J 71:1334–40, 1978.

    Article  PubMed  CAS  Google Scholar 

  6. Stone M, Bagshawe KD: An analysis of the influences of maternal age, gestational age, contraceptive method and mode of primary treatment of patients with hydatidiform moles on the incidence of subsequent chemotherapy. Brit J Obstet Gynaecol 86:782–792, 1979.

    Article  CAS  Google Scholar 

  7. Brandes JM, Grunstein S, Peretz A: Suction evacuation of the uterine cavity in hydatidiform mole. Obstet Gynecol 28:689–691, 1966.

    PubMed  CAS  Google Scholar 

  8. Bagshawe KD: Choriocarcinoma: The Clinical Biology of the Trophoblast and its Tumours, p 261. London: Arnold, 1969.

    Google Scholar 

  9. Stone M, Dent J, Kardana A, Bagshawe KD: Relationship of oral contraception to development of trophoblastic tumour after evacuation of a hydatidiform mole. Br J Obstet Gynaecol 83:913–916, 1976.

    Article  PubMed  CAS  Google Scholar 

  10. Baltazar JC: Epidemiological features of choriocarcinoma. Bull WHO 54:523–532, 1976.

    PubMed  CAS  Google Scholar 

  11. Berkowitzrs, Marean AR, Goldstein DP, Bernstein MR: Oral contraceptives and post-molar trophoblastic tumours. Lancet ii:752, 1980.

    Article  Google Scholar 

  12. Bagshawe KD, Stone M: Oral contraceptives and post-molar trophoblastic tumours. Lancet ii: 1250, 1980.

    Article  Google Scholar 

  13. McGrath IT, Golding PR, Bagshawe KD: Medical presentations of choriocarcinoma. Brit Med J 2:633–637, 1971.

    Article  Google Scholar 

  14. Searle F, Leake BA, Bagshawe KD, Dent J: Serum-SP1-pregnancy-specific-β-glycoprotein in choriocarcinoma and other neoplastic disease. Lancet i:579–581, 1978.

    Article  Google Scholar 

  15. Kardana A, Bagshawe KD: A rapid, sensitive and specific radioimmunoassay for human chorionic gonadotrophin. J Immunol Methods 9:297–305, 1976.

    Article  PubMed  CAS  Google Scholar 

  16. Bagshawe KD: Computer controlled automated radioimmunoassay. Lab Practice (September): 573–575, 1975.

    Google Scholar 

  17. Bagshawe KD, Harland S: Immunodiagnosis and monitoring of gonadotrophin-producing metastases in the central nervous system. Cancer 38:112–118, 1976.

    Article  PubMed  CAS  Google Scholar 

  18. Requard CK, Mettler FA: The use of ultrasound in the evaluation of trophoblastic disease and its response to therapy. Radiology 135:419–422, 1980.

    PubMed  CAS  Google Scholar 

  19. Cave WT, Durn JT: Choriocarcinoma with hyperthyroidism: probable identity of the thyrotropin with human chorionic gonadotrophon. Ann Int Med 85:60–63, 1976.

    PubMed  Google Scholar 

  20. Begent RHJ, Searle F, Stanway G, Jewkes RF, Jones BE, Vernon P, Bagshawe KD: Radioimmunolocalization of tumours by external scintigraphy after administration of 131I antibody to human chorionic gonadotrophin. J Roy Soc Med 23:624–630, 1980.

    Google Scholar 

  21. Goldenberg DM, Kim EE, Deland FM, van Nagell JR, Javadpour N: Clinical radioimmunodetection of cancer with radiolabelled antibodies to human chorionic gonadotrophin. Science 208:1284–1286, 1980.

    Article  PubMed  CAS  Google Scholar 

  22. Searle F, Boden J, Lewis JCM, Bagshawe KD: A human choriocarcinoma xenograft in nude mice; a model for study of antibody localization. Brit J Cancer 44:137–144, 1981.

    Article  PubMed  CAS  Google Scholar 

  23. Bagshawe KD: Risk and prognostic factors in trophoblastic neoplasia. Cancer 38:1373–1385, 1976.

    Article  PubMed  CAS  Google Scholar 

  24. Hammond CB, Borchert LG, Tyrey L, Creasman WT, Parker RT: Treatment of metastatic trophoblastic disease: good and poor prognosis. Am J Obstet Gynecol 115:451–457, 1973.

    PubMed  CAS  Google Scholar 

  25. Elston CW, Bagshawe KD: Cellular reaction in trophoblastic tumours. Br J Cancer 28:245–256, 1973.

    Article  PubMed  CAS  Google Scholar 

  26. Bagshawe KD: Treatment of trophoblastic tumours. Recent Results in Cancer Research 62:192–199, 1977.

    PubMed  Google Scholar 

  27. Walden PAM, Mitchell-Heggs PF, Coppin C, Dent J, Bagshawe KD: Pleurisy and methotrexate treatment. Brit Med J 2:867, 1980.

    Article  Google Scholar 

  28. Bagshawe KD, Newlands ES: High dose methotrexate in patients with trophoblastic tumours. In: High Dose Methotrexate, Pharmacology, Toxicology and Chemotherapy. Pereti P (ed), Firenze, Italy: Editrice Ginntina, 1978, pp 281–288.

    Google Scholar 

  29. Newlands ES, Bagshawe KD: Anti-tumour activity of the epipodophyllin derivative VP. 16–213 (Etoposide: NSC - 141540) in gestational choriocarcinoma. Europ J Cancer 16:401–405, 1980.

    Article  CAS  Google Scholar 

  30. Begent RHJ, Bagshawe KD: The management of high risk choriocarcinoma. Seminars in Oncology, 9:198–203, 1982.

    PubMed  CAS  Google Scholar 

  31. Newlands ES, Bagshawe KD: Activity of high dose Cis-platinum (NCI 119875) in combination with vincristine and methotrexate in drug-resistant choriocarcinoma. A report of 17 cases. Brit J Cancer 40:943–945, 1979.

    Article  PubMed  CAS  Google Scholar 

  32. Hayes DM, Cvitkovic E, Golbey RB, Scheiner E, Helson L, Krakoff RH: High dose Cisplatinum diammine dichloride. Amelioration of renal toxicity by mannitol diuresis. Cancer 39:1372–1381, 1977.

    Article  PubMed  CAS  Google Scholar 

  33. Hammond CB, Weed JC, Curie JL: The role of operation in the current therapy of gestational trophoblastic disease. Am J Obstet Gynecol 136:844–858, 1980.

    PubMed  CAS  Google Scholar 

  34. Weed JC, Hammond CB: Cerebral metastatic choriocarcinoma: Intensive therapy and prognosis. Obstet Gynecol 55:89–94, 1980.

    PubMed  Google Scholar 

  35. Brace KC: The role of irradiation in the treatment of metastatic trophoblastic disease. Radiology 91:540–544, 1968.

    Google Scholar 

  36. Athanassiou A, Begent RHJ, Newlands ES, Parker D, Rustin GJS, Bagshawe KD: Central nervous system metastases of chorio carcinoma: 23 years experience at Charing Cross Hospital. Cancer (in Press).

    Google Scholar 

  37. Tattersall MHN, Parker LM, Pittman SW, Frei E: Clinical pharmacology of high dose methotrexate. Cancer Chemother Rep 6:25–29, 1975.

    Google Scholar 

  38. Gregoriadis G: Targeting of drugs: Implications in medicine. Lancet ii:241–246, 1981.

    Article  Google Scholar 

  39. Bagshawe KD: Choriocarcinoma: Can we afford to cure cancer? Ann Roy Coll Surg of England 60:34–41, 1978.

    Google Scholar 

Download references

Authors
  1. Richard H. J. Begent
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kenneth D. Bagshawe
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Harvard Medical School, Brigham and Women’s Hospital, Boston, Massachusetts, USA

    C. Thomas Griffiths M.D.

  2. Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA

    Arlan F. Fuller Jr. M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Martinus Nijhoff Publishers, Boston

About this chapter

Cite this chapter

Begent, R.H.J., Bagshawe, K.D. (1983). Treatment of Advanced Trophoblastic Disease. In: Griffiths, C.T., Fuller, A.F. (eds) Gynecologic Oncology. Cancer Treatment and Research, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3852-9_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-3852-9_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3854-3

  • Online ISBN: 978-1-4613-3852-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation