Abstract
Hepatic metastases represent a common site of dissemination for a number of primary malignancies, especially gastrointestinal neoplasms. Sixty percent of patients with colorectal carcinoma develop liver metastases during the course of their illness ,1 and 30% will have hepatic metastases as the only site of disease .2 The average response rate of metastatic colon cancer to traditional bolus 5-FU is around 20%.3 The response rate is approximately the same even if patients with liver metastases are considered alone. While the addition of MeCCNU to 5-FU did not increase the response rate for the total population or for those with livermetastases, the combination of MeCCNU, 5-FU, Vincristine and Streptozotocin (MOF-Strep) increased the response rate for both groups up to around 30%.3
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References
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© 1984 Martinus Nijhoff Publishers, Boston
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Kemeny, N., Daly, J., Chun, H., Oderman, P., Petroni, G., Geller, N. (1984). Randomized Study of Intrahepatic vs Systemic Infusion of Fluorodeoxyuridine in Patients with Liver Metastases from Colorectal Carcinoma (Preliminary Results). In: Howell, S.B. (eds) Intra-Arterial and Intracavitary Cancer Chemotherapy. Developments in Oncology, vol 26. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3843-7_9
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DOI: https://doi.org/10.1007/978-1-4613-3843-7_9
Publisher Name: Springer, Boston, MA
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Online ISBN: 978-1-4613-3843-7
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