Medical Principles of Intraperitoneal and Intrapleural Chemotherapy

  • Maurie Markman
Part of the Developments in Oncology book series (DION, volume 26)


While modeling studies have suggested a major pharmacokinetic advantage for peritoneal cavity drug exposure to certain chemotherapeutic agents when administered by the intraperitoneal route (1), there are both theoretical and practical issues which must be addressed prior to the acceptance of this approach to the management of malignant disease principally confined to the peritoneal or pleural cavities. The importance of establishing a safe and simple method of accessing the abdominal cavity has been discussed in another paper in this symposium.


Peritoneal Dialysis Ovarian Carcinoma Pleural Fluid Pleural Cavity Body Cavity 
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© Martinus Nijhoff Publishers, Boston 1984

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  • Maurie Markman

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