The Use of Radiolabeled Antibody in Cancer Chemotherapy

  • S. E. Order
Part of the Developments in Oncology book series (DION, volume 26)

Abstract

Unavailable in the radiation armamentarium of modern day oncology are systemic and highly specific agents for selective radiation. Radiolabeled antibodies now offer both the specific selectivity as well as the opportunity for selective systemic irradiation which may be enhanced by appropriate chemotherapeutic integration.

Keywords

Toxicity Adenocarcinoma Turkey Thrombocytopenia Myeloma 

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References

  1. 1.
    Leichner, P. K., Klein, J. L., Garrison, J. B., Jenkins, R. E., Nickloff, E. L., Ettinger, D. S., Order, S. E.: Dosimetry of I–131 labeled antiferritin in hepatoma: A model for radioimmunoglobulin dosimetry. Int J Rad One Biol Phy (7): 323–333, 1981.CrossRefGoogle Scholar
  2. 2.
    Ettinger, D. S., Order, S. E., Wharam, M. D., Parker, M. Klein, J. L., Leichner, P. K.: Phase I–II study of isotopic immunoglobulin therapy for primary liver cancer. Cancer Treat Rep. (66): 289–297, 1982.PubMedGoogle Scholar
  3. 3.
    Order, S. E.: Monoclonal antibodies: Potential role in radiation therapy and oncology. Int J Rad One Biol Phys (8): 1193–1201, 1982.Google Scholar
  4. 4.
    Wright, T., Sinanan, M., Harrington, D., Klein, J. L., Order, S.E.: Immunoglobulin: Applications to scanning and treatment Applied Rad (8) 120–124, 1979.Google Scholar
  5. 5.
    Maxon, H. R., Thomas, S. R., Hertzberg, V. S., Kereiakes, J. G., Chen, I. W. Sperling, M. I., Saenger, E. L.: Relation between effective radiation dose and outcome of radioiodine therapy for thyroid cancer. New Eng J Med (309) 937–941, 1983.CrossRefGoogle Scholar
  6. 6.
    Order, S. E.: Radioimmunoglobulin therapy of cancer. Comprehensive Therapy (10): 9–18, 1984.PubMedGoogle Scholar
  7. 7.
    Shipley, W. U., Peacock, J. H., Steel, G. G., Stephens, T. C.: Continuous irradiation of the Lewis lung carcinoma in vivo at clinically used “ultra” low dose rates. Int J Rad One Biol Phys (9) 1647–1653, 1983.Google Scholar
  8. 8.
    Hilaris, B.S., Whitmore, W.F., Batata, M., Barzell, W.: Behavorial patterns of prostate adenocarcinoma following an 1–125 implant and pelvic lymphadenectomy. Int J Rad One Biol Phys (2) 631–637, 1977.CrossRefGoogle Scholar
  9. 9.
    Feldman, G. B., Knapp, R. C., Order, S. E., Hellman, S.: The Role of lymphatic obstruction in the formation of ascites in a murine ovarian carcinoma. Cancer Res (32) 1663–1666, 1972.PubMedGoogle Scholar
  10. 10.
    Order, S. E., Donahue, V., Knapp, R.: Immunotherapy of ovarian carcinoma. An experimental model. Cancer (32) 573–579, 1973.CrossRefGoogle Scholar
  11. 11.
    Suit, H., Order, S.E.: Considerations in the interactions of radiation and immunotherapy. In interaction of radiation and host immune defense mechanisms in malignancy. Brookhaven National Laboratory. New York, 1974, pp. 130–151.Google Scholar
  12. 12.
    Baker, L. H., Saiki, J. A., Jones, S.A.: Adriamycin and 5-fluorouracil in the treatment of advanced hepatoma: ASW one group study. Cancer Treat Rep (61): 1595–1598, 1977.Google Scholar
  13. 13.
    Sherman, D. M., Carabell, S.C., Belli, J. A., Hellman S.: The effect of dose rate and adriamycin on the tolerance of thoracic radiation in mice. Int J Rad One Biol Phys (8): 45–51, 1982.Google Scholar
  14. 14.
    Moertel, C. G., Childs, Jr., D. S., Reitemeier, R. J., Colby, Jr., M. Y., Holbrook, M. A.: Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer. The Lancet: 865–867, 1969.Google Scholar
  15. 15.
    Machr J. P., Chatal, J.F., Lumbrosof S.D., Bacheggif F., Forni, M., Pitchard, J., Beiche, C., Douillard, J. Y., Carrelf S., Herlyn, M., Steplewski, Z, Koprowski, H.: Tumor localization in patients by radiolabelled monoclonal antibodies against colon carcinoma. Cancer Res (43) 5593–5600, 1983.Google Scholar
  16. 16.
    Epenetos, A. A., Britton, K. E., Mather, S., Sheperd, J., Granowska, M., Taylor-Papadimitriou, J., Nimmon C. C., Durbin, H., Hawkins, L. R., Malpas. J. S., Bodmer, W. F.: Targeting of iodine-123 labelled tumor-associated monoclonal antibodies to ovarian, breast, and gastrointestinal tumors. Lancet (6) 999–1005, 1982.Google Scholar
  17. 17.
    Rostock, R. A., Klein, J. L., Leichner, P. K., Kopher, K. A., Order, S.E.: Selective tumor localization in experimental hepatoma by radiolabeled antiferritin antibody. Int J Rad One Biol Phys (9) 1345–1350, 1983.CrossRefGoogle Scholar
  18. 18.
    Rostock, R. A., Klein, J. L., Kopher, K. A., Order, S.E.: Variables affecting the tumor localization of I–131 antiferritin in experimental hepatoma. Amer J CI One (in press).Google Scholar
  19. 19.
    Order, S. E., Ettinger, D. S., Leibel, S. A., Klein, J. L., Leichner, P. K.: Cyclic radiolabeled I–131 antiferritin in multimodality therapy of hepatocellular carcinoma. Proc Amer Soc CI One (2) 119, 1983.Google Scholar
  20. 20.
    Lenhard, R. E., Order, S. E., Spunberg, J. J., Ettinger, D. S., Asbell, S. O., Leibel, S. A.: Radioimmunoglobulins: A new therapeutic modality in Hodgkin s disease. Proc Amer Soc CI One (2) 211, 1983.Google Scholar
  21. 21.
    Order, S. E., Klein, J. L., Ettinger, D., Alderson, P., Siegelman, S., Leichner, P.: Phase I–II study of radiolabeled antibody integrated in the treatment of primary hepatic malignancies. Int J Rad One Biol Phys (6): 703–710, 1980.CrossRefGoogle Scholar
  22. 22.
    Order, S. E., Klein, J. L., Leichner, P. K., Wharam, M.D., Chambers, J., Kopher, K., Ettinger, D. S., Siegelman, S.S.: Radiolabeled antibodies in the treatment of primary liver malignancies. In: Levin, B. Riddel, R. (eds) Gastrointestinal Cancer. Elsevier North-Holland, New York (in press).Google Scholar
  23. 23.
    Kohler, G., Howe, S. C., Milstein, C.: Fusion between immunoglobulin-nonsecreting myeloma cell lines. Eur J Immunol (6) 292–295, 1976.PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers, Boston 1984

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  • S. E. Order

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