Abstract
The rationale, methodology and early experience with intra-arterial infusion of BCNU will be described. Internal carotid artery BCNU is now used as standard therapy for post-operative glioblastoma in at least five institutions. The approach allows for five-fold multiples of drug into localized intracerebral tumor without increasing systemic toxicity. Major complications are limited to ipsilateral eye pain and diminished acuity treated with systemic analgesia, retro-orbital bipuvacaine block or avoided by supra-ophthalmic carotid artery infusion. However, the latter is associated with leukoencephalopathic changes seen as low absorption on CT scan. We will present our experience with 171 infusions of BCNU amongst 54 patients including:
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a)
Patients with post-operative and postirradiation recurrent glioblastoma who experienced 54 weeks median survival following recurrence.
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b)
Patients with newly diagnosed and irradiated glioblastoma who have median survival of 53+ weeks(following infraopthalmic infusion) and 56+ weeks (for three or more supraophthalmic artery infusions)
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c)
Patients receiving intra-arterial BCNU in advance of irradiation.
Supported by the Naragansett Foundation and the Farber and Sanford Funds.
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© 1984 Martinus Nijhoff Publishers, Boston
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Hochberg, F.H., Pruitt, A., Beck, D., DeBruyn, G., Davis, K. (1984). The Rationale and Methodology for Intra-arterial Chemotherapy with BCNU as Treatment for Glioblastoma. In: Howell, S.B. (eds) Intra-Arterial and Intracavitary Cancer Chemotherapy. Developments in Oncology, vol 26. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3843-7_10
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DOI: https://doi.org/10.1007/978-1-4613-3843-7_10
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