Current Clinical Progress — Podophyllotoxins

  • Brian F. Issell
Part of the Developments in Oncology book series (DION, volume 23)


Podophyllotoxin is a compound derived from the roots or rhyzomes of certain plants of the genus Podophyllum (Mandrake, American May apple). VP-16, or etoposide, and VM-26, or teniposide, are semisynthetic derivatives of podophyllotoxin. They differ from the parent compound podophyllotoxin and other classical spindle poisons such as colchicine, vincristine, and vinblastine by not interacting with tubulin or interfering with microtubule assembly (1).


Small Cell Lung Cancer Testicular Cancer Small Cell Carcinoma Salvage Setting Testicular Cancer Patient 
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© Martinus Nijhoff Publishing, Boston 1984

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  • Brian F. Issell

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