Hormone Receptors in Gynecological Tumours and their Relevance for Therapeutic Management
The effect of steroid hormones is mediated by the interaction with specific hormone receptors of the target cell. It was obvious, that this concept should be applied to the management of so-called hormone responsive tumours. Steroid-hormone receptors - mostly oestrogen receptors - have been detected in the following neoplasias of the female reproductive system: cervical cancer, endometrial cancer, ovarian cancer, breast cancer. Our information on the implication and function of receptor protein in these tumours is still incomplete and their presence does not necessarily indicate responsiveness to endocrine manipulation. Although there is a reasonable chance of successful hormonal treatment of carcinomas of the endometrium and the breast, the same does not hold true for cervical and ovarian cancers. The present paper deals with the practical value of receptor measurements in patients with endometrial, ovarian or breast cancer.
KeywordsTamoxifen Progesterone Progestin Danazol
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