Advertisement

Antibody-Toxin Conjugates as Anti-Cancer Agents

  • Philip E. Thorpe
Part of the Developments in Oncology book series (DION, volume 23)

Abstract

A possible means of making anti-cancer agents that has excited much recent interest is to link highly potent toxins of bacterial or plant origin to monoclonal antibodies with specificity for tumour cells. Ricin, from castor beans, and abrin, from jequirity beans, have been the two plant toxins most widely used. The attraction of these toxins is their supremely powerful cytotoxic action. It has been calculated that just one molecule needs to penetrate a cell to kill it. This maximises the likelihood of killing malignant cells that do not have a high density of specific antigens on their surface or that reside in solid tumours not freely permeable to the conjugate.

Keywords

Castor Bean Iodoacetic Acid Potent Toxin Imperial Cancer Research Fund Conjugate Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Olsnes, S & Pihi, A. Toxic lectins and related proteins. In: Cohen, P, Van Heyningen, S (eds) Molecular Action of Toxins and Viruses. Elsevier Biomed. Press, New York, 1982, pp 51–105.Google Scholar
  2. 2.
    Thorpe, PE & Ross, WCJ. The preparation and cytotoxic properties of antibody-toxin conjugates. Immunol. Rev. 119–158, 1982.Google Scholar
  3. 3.
    Thorpe, P E, Mason, D W, Brown, A N F, Simmonds, S J, Ross W C J, Cumber, A J, & Forrester, J A. Selective killing of malignant cells in a leukaemic rat bone marrow using an antibody-ricin conjugate. Nature 297, 594–596, 1982.PubMedCrossRefGoogle Scholar
  4. 4.
    Youle, R J & Neville D M. Kinetics of protein synthesis inactivation by ricin-anti-Thy 1.1 monoclonal antibody hybrids. J Biol. Chem. 257, 1598–1601, 1982.PubMedGoogle Scholar
  5. 5.
    Thorpe, PE, Brown, A, Foxwell, B, Myers, C, Ross, W, Cumber, A, & Forrester, A. Blockade of the galactose-binding site of ricin by its linkage to antibody. In: Boss, DB, Langman, RE, Trowbridge IS & Dulbecco, R (eds) Monoclonal Antibodies in Cancer. Proceedings of the IV Armand Hammer Cancer Symp. Acad. Press, New York, 1983, (in press).Google Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1984

Authors and Affiliations

  • Philip E. Thorpe

There are no affiliations available

Personalised recommendations