Antibody-Toxin Conjugates as Anti-Cancer Agents
A possible means of making anti-cancer agents that has excited much recent interest is to link highly potent toxins of bacterial or plant origin to monoclonal antibodies with specificity for tumour cells. Ricin, from castor beans, and abrin, from jequirity beans, have been the two plant toxins most widely used. The attraction of these toxins is their supremely powerful cytotoxic action. It has been calculated that just one molecule needs to penetrate a cell to kill it. This maximises the likelihood of killing malignant cells that do not have a high density of specific antigens on their surface or that reside in solid tumours not freely permeable to the conjugate.
KeywordsToxicity Carbohydrate Lymphoma Glutathione Polypeptide
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