Skip to main content
SpringerLink
Log in

Overview on Blood Coagulation Proteins

  • Chapter
Hemostatic Mechanisms and Metastasis

Part of the book series: Developments in Oncology ((DION,volume 22))

  • 29 Accesses

Abstract

Coagulation of blood results from the conversion of a soluble plasma protein, fibrinogen, into fibrin monomers which undergo spontaneous polymerization to form an isoluble network of fibers. Under normal circumstances clotting is brought about by a sequence of reactions which can be likened to a cascade, in which the activation of one coagulation factor triggers a change in the next coagulation factor to its active form (Figure 1). This zymogen-to-enzyme conversion sequence allows for linear and nonlinear amplification as well as feedback regulation of the system. Blood platelets participate in coagulation by providing phospholipid or lipoprotein surfaces upon which the coagulation proteins are brought into contact with one another. Mammalian blood also contains an enzyme system, termed the fibrinolytic enzyme system, which is capable of dissolving blood clots. This chapter will provide a summary of these basic features of the blood coagulation system.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Matthews DA, Alden RA, Birktoft JJ, Freer ST and Kraut J. J. Biol. Chem. 250: 7120–7126, 1975.

    PubMed  CAS  Google Scholar 

  2. Blow DM, Birktoft JJ and Hartley BS. Nature (London) 221: 337–340, 1969.

    Article  CAS  Google Scholar 

  3. Davie EW, Fujikawa K, Kurachi K and Kisiel W. Methods Enzymol. 48: 227–318, 1979.

    Google Scholar 

  4. Stroud RM, Kreger M, Koeppe RE, Kossiakoff AA and Chambers JL. In: Proteases and Biological Control (Eds. Reich E, Rifkin DB and Shaw E), Cold Spring Harbor Laboratory, New York, pp. 13–32, 1975.

    Google Scholar 

  5. Stroud RM. Sci. Am. 231: 74–88, 1974.

    Article  PubMed  CAS  Google Scholar 

  6. Radcliffe R and Nemerson Y. J. Biol. Chan. 251: 4797–4802, 1976.

    CAS  Google Scholar 

  7. Radcliffe R and Nemerson Y. J. Biol. Chem. 250: 388–395, 1975.

    PubMed  CAS  Google Scholar 

  8. Silverberg SA, Ostapehuk P and Nemerson Y. Blood 48: 976, 1976.

    Google Scholar 

  9. Kisiel W, Fujikawa K and Davie EW. Biochemistry 16: 4189–4194, 1977.

    Article  PubMed  CAS  Google Scholar 

  10. Bouma B and Griffin JH. J. Biol. Chem. 252: 6432–6437, 1977.

    PubMed  CAS  Google Scholar 

  11. Kurachi K and Davie EW. Biochemistry 16: 5831–5839, 1977.

    Article  PubMed  CAS  Google Scholar 

  12. Revak SD, Cochrane GG and Griffin JH. J. CLin. Invest. 59: 1167–1175, 1977.

    Article  PubMed  CAS  Google Scholar 

  13. Suttie JW and Jackson CM. Physiol. Rev. 57: 1–70, 1977.

    PubMed  CAS  Google Scholar 

  14. Magnusson S, Sottrup-Jensen L, Petersen TE and Claeys H. In: Prothrombin and Related Coagulation Factors (Eds. Hemker HC and Veltkamp JJ), Leiden University Press, Leiden, pp. 25–46, 1975.

    Google Scholar 

  15. Jackson CM. Br. J. Haematol. 39: 1–8, 1978.

    Article  PubMed  CAS  Google Scholar 

  16. Seegers WH, Hassouna HI, Hewett-Bnmett D, Walz DA and Andary TJ. Serain. Thraab. Hemostasis, pp. 211–283, 1975.

    Google Scholar 

  17. Jackson CM and Nemerson Y. Annu. Rev. Biochem. 49: 765–781, 1980.

    Article  PubMed  CAS  Google Scholar 

  18. Dam H. Biochem. Z. 215: 468, 1929.

    CAS  Google Scholar 

  19. Dam H. Biochen. Z. 215: 475, 1929.

    Google Scholar 

  20. Dam H. Biochem. Z. 220: 158, 1930.

    CAS  Google Scholar 

  21. Dam H. Nature (London) 135: 652, 1935.

    Article  CAS  Google Scholar 

  22. Dam H. Biochem. J. 29: 1273, 1935.

    PubMed  CAS  Google Scholar 

  23. Owen CA, Jr., Magath TB and Bollman JL. Am. J. Physiol. 166: 1–11, 1951.

    PubMed  CAS  Google Scholar 

  24. Koller F, Loeliger A and Duckert F. Acta Haematol. 6: 1–18, 1951.

    Article  PubMed  CAS  Google Scholar 

  25. Aggeler PM, White SG, Glendering MB, Page EW, Leake TB and Bates G. Proc. Soc. Exp. Biol. Med. 79: 692–694, 1952.

    PubMed  CAS  Google Scholar 

  26. Biggs R, Douglas AS, Macfarlane RG, Dacie JV, Pitney WR, Merskey C and O’Brien JR. Br. Med. J. 2: 1378–1382, 1952.

    Article  PubMed  CAS  Google Scholar 

  27. Hougie C, Barrow EM and Graham JB. J. Clin. Invest. 36: 485–496, 1957.

    Article  PubMed  CAS  Google Scholar 

  28. Stenflo J. J. Biol. Chem. 251: 355–363, 1976.

    PubMed  CAS  Google Scholar 

  29. DiScipio RG, Hermodson MA, Yates SG and Davie EW. Biochemistry 16: 698–706, 1977.

    Article  CAS  Google Scholar 

  30. Prowse CV and Esnouf MP. Biochem. Soc. Trans. 5: 255–256, 1977.

    PubMed  CAS  Google Scholar 

  31. Marciniak E. J. Lab. CLin. Med. 79: 924–934, 1972.

    PubMed  CAS  Google Scholar 

  32. Marciniak E. Science 170: 452, 1970.

    Article  PubMed  CAS  Google Scholar 

  33. Kisiel W, Canfield WM, Ericsson LH and Davie EW. Biochemistry 16: 5824–5831, 1979.

    Article  Google Scholar 

  34. Kisiel W. J. Clin. Invest. 64: 761–769, 1979.

    Article  PubMed  CAS  Google Scholar 

  35. Seegers VH, McCoy LE, Groben HD, Sakuragawa N and Agrawal BL. Thranb. Res. 1: 443–460, 1972.

    Article  CAS  Google Scholar 

  36. Esmon CT, Comp PC and Walker FJ. In: Vitanin K Metabolism and Vitamin K-Dependent Proteins (Ed. Suttie JW), University Park Press, pp. 72–83, 1980.

    Google Scholar 

  37. Walker FJ. J. Biol. Chem. 255: 5521–5524, 1980.

    PubMed  CAS  Google Scholar 

  38. Walker FJ. J. Biol. Chem. 256: 11128–11131, 1981.

    PubMed  CAS  Google Scholar 

  39. Hemker HC, Veltkamp JJ, Hensen A and Loeliger EA. Nature (London) 200: 589–590, 1963.

    Article  CAS  Google Scholar 

  40. Ganrot PO and Nilehn JE. Scand. J. CLin. Lab. Invest. 22: 23–28, 1968.

    Article  CAS  Google Scholar 

  41. Stenflo J. Acta Chem. Scand. 24: 3762–3763, 1970.

    Article  PubMed  CAS  Google Scholar 

  42. Nelsestuen GL and Suttie JW. J. Biol. Chem. 247: 8176–8182, 1972.

    PubMed  CAS  Google Scholar 

  43. Reekers PP, Lindout MJ, Kop-Klaassen BHM and Hemker HC. Biochim. Biophys. Acta 317: 559–562, 1973.

    PubMed  CAS  Google Scholar 

  44. Suttie JW. In: Handbook of Lipid Research. Plenum Press, New York, 2: 211–277, 1978.

    Google Scholar 

  45. Stenflo J, Fernlund P, Eagan W and Roepstorff P. Proc. Natl. Acad. Sci. USA 71: 2730–2733, 1974.

    Article  PubMed  CAS  Google Scholar 

  46. Gitel SN, Oiven WG, Esmon CT and Jackson CM. Proc. Natl. Acad. Sci. USA 70: 1344–1348, 1973.

    Article  PubMed  CAS  Google Scholar 

  47. Esmon CT, Suttie JW and Jackson CM. J. Biol. Chan. 250: 4095–4099, 1975.

    CAS  Google Scholar 

  48. Lindhout MI, Kop-Klaassen BHM and Honker HC. Biochim. Biophys. Acta 533: 342–345, 1978.

    CAS  Google Scholar 

  49. Doolittle RF. Horiz. Biochem. Biophys. 3: 164–191, 1977.

    PubMed  CAS  Google Scholar 

  50. Doolittle RF. In: The Plasma Proteins (Ed. Putnam FW), Academic Press, New York, 2: 109–161, 1975.

    Google Scholar 

  51. Loewy AG, Dahlberg A, Dunathan D, Kreil R and Wolfinger HL, Jr. J. Biol. Chan. 236: 2634–2643, 1961.

    CAS  Google Scholar 

  52. Schwartz ML, Pizzo SV, Hill RL and Mtffee PA. J. Biol. Chem. 248: 1395–1407, 1973.

    PubMed  CAS  Google Scholar 

  53. Bohn H, Haupt H and Kranz T. Blut 25: 235–248, 1972.

    Article  PubMed  CAS  Google Scholar 

  54. Folk JE and Chung SI. Adv. Enzymol. Relat. Areas Mol. Biol. 38: 109–191, 1973.

    PubMed  CAS  Google Scholar 

  55. Folk JE and Finlayson JS. Adv. Protein Chan. 31: 1–133, 1977.

    Article  CAS  Google Scholar 

  56. Gerth C, Roberts WW and Ferry JD. Biophys. Chem. 2: 208–217, 1974.

    Article  PubMed  CAS  Google Scholar 

  57. Griffin JH and Cochrane CG. Semin. Thromb. Hemostasis 5: 254–273, 1979.

    CAS  Google Scholar 

  58. Bouma BN and Griffin JH. J. Biol. Chem. 252: 6432–6437, 1977.

    PubMed  CAS  Google Scholar 

  59. Bouma BN and Griffin JH. Thromb. Haanostasis 38: 136, 1977.

    Google Scholar 

  60. Griffin JH and Cochrane CG. Proc. Natl. Acad. Sci. USA 73: 2554–2558, 1976.

    Article  PubMed  CAS  Google Scholar 

  61. Meier HK, Webster ME, Mandle T, Colman RW and Kaplan AP. J. Clin. Invest. 60: 18–31, 1977.

    Article  PubMed  CAS  Google Scholar 

  62. Revak SD, Cochrane CG, Botma BN and Griffin JH. J. Exp. Med. 147: 719–729, 1978.

    Article  PubMed  CAS  Google Scholar 

  63. Rijikawa K, Legaz ME, Kato H and Davie EW. Biochemistry 13: 4508–4516, 1974.

    Article  Google Scholar 

  64. Suttie JW and Jackson CM. Physiol. Rev. 57: 1–70, 1977.

    PubMed  CAS  Google Scholar 

  65. Wiggins RC, Loskutoff EJ, Cochrane CG, Griffin JH and Edgington TS. J. Clin. Invest. 65: 197–206, 1980.

    Article  PubMed  CAS  Google Scholar 

  66. NiewiarowskL S, Bankowski L and Fiedoreck T. Experientia 20: 367, 1964.

    Article  Google Scholar 

  67. Wilner GD, Nossel HL and Leroy EC. J. Clin. Invest. 47: 2608–2615, 1968.

    Article  PubMed  CAS  Google Scholar 

  68. Biggs R and Nossel HL. Thromb. Diath. Haemorrh. 6: 1–4, 1961.

    CAS  Google Scholar 

  69. Josso F and Prou-Wartelle O. Thromb. Diath. Haemorrh. 17: 35–44, 1965.

    CAS  Google Scholar 

  70. Osterud B and Rapaport SI. Proc. Natl. Acad. Sci. USA 74: 5250–5264, 1977.

    Article  Google Scholar 

  71. Zur M, Shastri K and Nanerson Y. Blood 52: 198, 1978.

    Google Scholar 

  72. Marlar RA, Kleiss AJ and Griffin JH. Blood 60: 1353–1358, 1982.

    PubMed  CAS  Google Scholar 

  73. Esmon CI, Stenflo J, Suttie JW and Jackson CM. J. Biol. Chem. 251: 3052–3056, 1976.

    PubMed  CAS  Google Scholar 

  74. Kisiel W, Ericsson LH and Davie EW. Biochemistry 15: 4893–4900, 1976.

    Article  PubMed  CAS  Google Scholar 

  75. Esmon NL, Owen WG and Esmon CT. J. Biol. Chem. 257: 859–864, 1982.

    PubMed  CAS  Google Scholar 

  76. Marlar RA, Kleiss AJ and Griffin JH. Blood 59: 1064–1072, 1982.

    Google Scholar 

  77. Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ and Widanan C. J. Clin. Invest. 68: 1370–1373, 1981.

    Article  PubMed  CAS  Google Scholar 

  78. Bertiria RM, Broekmans AW, van der Linden IK and Martens K. Thromb. Haemostasis 48: 1–5, 1982.

    Google Scholar 

  79. Egeberg O. Thromb. Diath. Haanorrh. 13: 516–530, 1965.

    CAS  Google Scholar 

  80. Marciniak E, Farley CH and DeSimone PA. Blood 43: 219–231, 1974.

    PubMed  CAS  Google Scholar 

  81. Abildgaard U. In: The Physiological Inhibitors of Coagulation and Fibrinolysis (Eds. Gollen D, Wiman B and Verstraete M), Elsevier/North Holland, Amsterdam, pp. 19–29, 1979.

    Google Scholar 

  82. Tollefson EM and Blank MK. J. Clin. Invest. 68: 589–596, 1981.

    Article  Google Scholar 

  83. Abildgaard U. In: The Physiological Inhibitors of Blood Coagulation and Fibrinolysis (Eds. Gollen D, Wiman B, Verstraete M),. Elsevier/North Holland, Amsterdan, pp. 239–241, 1979.

    Google Scholar 

  84. Abildgaard U. Scand. J. Clin. Lab. Invest. 19: 190–195, 1967.

    Article  Google Scholar 

  85. Shapiro SS and Anderson DB. In: Chemistry and Biology of Thrombin (Eds. Lundbland RL, Fenton JW and Mann KG), Ann Arbor Science, Ann Arbor, MI, pp. 1361–1374, 1977.

    Google Scholar 

  86. Harpel PC. Methods Enzymol. 45: 751–760, 1976.

    Article  PubMed  CAS  Google Scholar 

  87. Learned IA, Bloom JW and Hunter MJ. Thromb. Pes. 8: 99–109, 1976.

    Article  CAS  Google Scholar 

  88. Heck LW and Kaplan AL. J. Exp. Med. 140: 1615–1630, 1974.

    Article  PubMed  CAS  Google Scholar 

  89. Walsh PN. Br. J. Haematol. 22: 205–217, 1972.

    Article  PubMed  CAS  Google Scholar 

  90. Milstone JH. Fed. Proc. Fed. An. Soc. Exp. Biol. 23: 742–748, 1964.

    CAS  Google Scholar 

  91. Schiffman S, Rapaport SI and Chong MMY. Proc. Soc. Exp. Biol. Med 123: 736–742, 1966.

    PubMed  CAS  Google Scholar 

  92. Joist JH, Dolezel G, Lloyd JV, Kinloughr-Rathbone KL and Mustard JF. J. Lab Clin. Med. 84: 474–482, 1974.

    CAS  Google Scholar 

  93. Mustard JF, Moore S, Packhan MA and Kinlough-Rathbone KL. Prog. Biochem Pharmacol. 14: 312–325, 1977.

    Google Scholar 

  94. Brown TR, Ho-Li TTS and Walz DA. Clin. Chim. Acta 101: 225–233, 1980.

    Article  PubMed  CAS  Google Scholar 

  95. James HL, Ganguly P and Jackson CW. Thromb. Haeraostasis 38: 939, 1977.

    CAS  Google Scholar 

  96. Chesney CM, Pifer D and Colman RW. Proc. Natl. Acad. Sci. USA 78: 5180–5184 1981.

    Article  PubMed  CAS  Google Scholar 

  97. Ittyerah TR, Rawala R and Colman RW. Thromb. Haemostasis 42: 324, 1979.

    Google Scholar 

  98. Slot JW, Bouma BN, Montgomery R and Zimmerman TS. Thranb. Res. 13: 871–881, 1978.

    Article  CAS  Google Scholar 

  99. Schwartz ML, Pizzo V, Hill RL and McKee PA. J. Biol. Chem. 248: 1395–1407, 1973.

    PubMed  CAS  Google Scholar 

  100. Lipscomb MA and Walsh PN. J. Clin. Invest. 63: 1006–1014, 1979.

    Article  PubMed  CAS  Google Scholar 

  101. Connelan JM, Bouden DS, Smith I and Castaldi PA. Thranb. Res. 17: 225–238 1980.

    Article  Google Scholar 

  102. Schiffinan S, Rimon A and Rapaport SI. Br. J. Haematol. 35: 429–436, 1977.

    Article  Google Scholar 

  103. Schuaier AH, Tuszynski GP, Walsh PN and Colman RW. Clin. Res. 28: 323, 1980.

    Google Scholar 

  104. Miletich JP, Jackson CM and Majerus PW. J. Biol. Chem. 253: 6908–6916, 1978.

    PubMed  CAS  Google Scholar 

  105. Miletich JP, Majerus DW and Majerus PW. J. Clin. Invest. 62: 82–831, 1978.

    Article  Google Scholar 

  106. Walsh PN. Br. J. Haematol. 22: 237–254, 1972.

    Article  PubMed  CAS  Google Scholar 

  107. Walsh PN and Griffin JH. Blood 57: 106–118, 1981.

    PubMed  CAS  Google Scholar 

  108. Greengard JS, Walsh PN and Griffin JH. Blood 58: 194, 1981.

    Google Scholar 

  109. Ratnoff OD. In: Haemostasis: Biochemistry, Physiology and Pathology (Eds Ogston D and Bennett B), John Wiley and Sons, London, pp. 25–35, 1977.

    Google Scholar 

  110. Qgston D and Bennett B. Br. Med. Bull. 34: 107–112, 1978.

    Google Scholar 

  111. Collen D. Thromb. Haemostasis 43: 77, 1980.

    CAS  Google Scholar 

  112. Todd AS. J. Pathol. Bacteriol. 78: 281–283, 1959.

    Article  PubMed  CAS  Google Scholar 

  113. Thorsen S, Glas-Greenwalt P and Astrup T. Thromb. Diath. Haemorrh. 28: 65–73 1972.

    PubMed  CAS  Google Scholar 

  114. Camiolo SM, Thorsen S and Astrup T. Proc. Soc. Exp. Biol. Med. 138: 277–280 1971.

    PubMed  CAS  Google Scholar 

  115. Wallen P. In: Thrombosis and Urokinase (Eds. Paoletti R and Sherry S) Academic Press, London, pp. 91–102, 1977.

    Google Scholar 

  116. Gurewich V, Hyde E and Iipinski B. Blood 46: 555–556, 1975.

    PubMed  CAS  Google Scholar 

  117. Mallertz S. Ph.D. Thesis, Eijnar Munksgaard, Copenhagen, 1956.

    Google Scholar 

  118. Wiman B and Collen D. Nature (London) 272: 549–550, 1973.

    Article  Google Scholar 

  119. Fletcher AP, Biederman O, Moore D, Alkjersign N and Sherry S. J. Clin. Invest 43: 681–695, 1964.

    Article  PubMed  CAS  Google Scholar 

  120. Tytgat G, Collen D and DeVreker RA. Acta Haematol. 40: 265–274, 1968.

    Article  PubMed  CAS  Google Scholar 

  121. Collen D. Eur. J. Biochem. 69: 209–216, 1976.

    Article  PubMed  CAS  Google Scholar 

  122. Moroi M and Aoki N. J. Biol. Chan. 251: 5956–5965, 1976.

    CAS  Google Scholar 

  123. Mullertz S and Cleramensen I. Biochem. J. 159: 545–553, 1976.

    PubMed  CAS  Google Scholar 

  124. Aoki N, Saito H, Kamiya T, Koie K, Sakata Y and Masaremi K. J. Clin. Invest 63: 877–884, 1979.

    Article  PubMed  CAS  Google Scholar 

  125. Kluft C, E and Brainier EJP. Lancet 2: 206, 1979.

    Article  PubMed  CAS  Google Scholar 

  126. Miles IA, Plow EF, Donnelly KJ, Hougie C and Griffin JH. Blood 59: 1240–1251, 1982.

    Google Scholar 

  127. Bloom A.L. In: Haeniostasis and Thrombosis (Eds. Bloom AL and Thomas DP), Churchill Livingstone, Edinburgh, pp. 321–370, 1981.

    Google Scholar 

Download references

Authors
  1. Joyce E. Gardiner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. John H. Griffin
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Wayne State University, 210 Science Hall, Detroit, 48202, MI, USA

    Kenneth V. Honn

  2. Department of Pharmacology, Wayne State University, 540 East Canfield, Detroit, 48201, MI, USA

    Bonnie F. Sloane

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Martinus Nijhoff Publishing, Boston

About this chapter

Cite this chapter

Gardiner, J.E., Griffin, J.H. (1984). Overview on Blood Coagulation Proteins. In: Honn, K.V., Sloane, B.F. (eds) Hemostatic Mechanisms and Metastasis. Developments in Oncology, vol 22. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3831-4_3

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-3831-4_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3833-8

  • Online ISBN: 978-1-4613-3831-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation