The Hemolytic-Uremic Syndromes: The Most Important Cause of Acute Renal Failure in Infants and Children

  • Bernard S. Kaplan
  • Paul R. Goodyer
  • Jack S. C. Fong
  • Peter D. Thomson
Part of the Developments in Nephrology book series (DINE, volume 7)


Dr. M.A. Kibel, thundering like the Victoria Falls when the Zambezi River is in full flood, wrote in the Year Book of Pediatrics (1966–1967) that “there are still a few skeptics who would doubt the existence of a malady…affecting young children…(which is) characterized by hemolytic anemia and nephropathy of varying degrees.” “There is no doubt,”quoth he, “that this fascinating syndrome has not engendered the interest it deserves, presumably because the Great Seats of Learning, other than Johannesburg and Buenos Aires, have not experienced outbreaks. So, put an end to this torpor, Mr. Editor, sir. Step out and proclaim an International Conference of Gasser’s Syndrome!” Dr. Gellis gave one of his clasical replies: “(That Kibel is a gasser. — Ed.)” (1).


Hemolytic Anemia Recurrent Episode Thrombotic Thrombocytopenic Purpura Infectious Mononucleosis Thrombotic Microangiopathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Kibel, M.A.: Year Book of Pediatrics 1966–1967. Gellis, S.S. (ed.). Chicago, Year Book Medical Publishers, 1967, p. 301.Google Scholar
  2. 2.
    Gasser, C., Gauthier, E., Steck, A., et al.: Hamolytisch-uramische Syndrome: Bilaterale Nierenrindennekrosen bei akuten erworbenen Hamolytischen Anamien. Schweiz Med Wochensch 38: 905, 1955Google Scholar
  3. 3.
    Van Wierengen, P.M.V., Monnens, L.A.H., and Schretlen, E.D.A.M.: Haemolytic-uraemic syndrome. Epidemiological and clinical study. Arch Dis Child 49: 432, 1974CrossRefGoogle Scholar
  4. 4.
    Raghupathy, P., Date, A., Shastry, J.C.M., et al.: Haemolytic- uraemic syndrome complicating shigella dysentery in South Indian children. Br Med J 2: 1518, 1978CrossRefGoogle Scholar
  5. 5.
    Gianantonio, C.A., Vitacco, M., Mendilaharzu, F., et al.: The hemolytic-uremic syndrome. Nephron 11: 174, 1973PubMedCrossRefGoogle Scholar
  6. 6.
    Gianantonio, C.A., Vitacco, M., Mendilaharzu, F., et al.: The hemolytic-uremic syndrome. J Pediatr 64: 478, 1964PubMedCrossRefGoogle Scholar
  7. 7.
    Mettler, N.E.: Isolation of a microtatobiote from patients with hemolytic-uremic syndrome and thrombotic thrombocytopenic purpura and from mites in the United States. N Engl J Med 281: 1023, 1969PubMedCrossRefGoogle Scholar
  8. 8.
    Kaplan, B.S., and de Chadarevian, J-P.: Hemolytic-uremic syndrome. Canad Med Assoc J 117: 1246, 1977PubMedGoogle Scholar
  9. 9.
    Lieberman, E.: Hemolytic-uremic syndrome. J Pediatr 80: 1, 1972PubMedCrossRefGoogle Scholar
  10. 10.
    Koster, F., Levin, J., Walker, L., et al.: Hemolytic-uremic syndrome after shigellosis: Relation to endotoxemia and circulating immune complexes. N Engl J Med 298: 927, 1978PubMedCrossRefGoogle Scholar
  11. 11.
    Brandslund, I., Petersen, P.H., Strunge, P., et al.: Haemolytic uraemic syndrome and accumulation of haemoglobin-haptoglobin complexes in plasma in serum sickness caused by penicillin drugs. Haemostasis 9: 193, 1980PubMedGoogle Scholar
  12. 12.
    Monnens, L., van Aken, W., and De Jong, M.: “Active” intravascular coagulation in the epidemic form of hemolytic-uremic syndrome. Clin Nephrol 17: 284, 1982PubMedGoogle Scholar
  13. 13.
    Brain, M.C.: The haemolytic-uraemic syndrome. Semin Hematol 6: 162, 1969PubMedGoogle Scholar
  14. 14.
    Katz, J., Krawitz, S., Sacks, D.V., et al.: Platelet, erythrocyte, and fibrinogen kinetics in the hemolytic-uremic syndrome of infancy. J Pediatr 83: 739, 1973PubMedCrossRefGoogle Scholar
  15. 15.
    Courtecuisse, V., Habib, R., and Mornier, C.: Nonlethal hemolytic and uremic syndromes in children: An electron-microscope study of renal biopsies from six cases. Exp Mol Pathol 7: 327, 1967PubMedCrossRefGoogle Scholar
  16. 16.
    Miller, K., Dresner, I.G., and Michael, A.F.: Localization of platelet antigens in human kidney disease. Kidney Int 18: 472, 1980PubMedCrossRefGoogle Scholar
  17. 17.
    Bergstein, J.M., Kuoderli, U., Bang, N.U.: Plasma inhibitor of glomerular fibrinolysis in the hemolytic-uremic syndrome. Am J Med 73: 322, 1982PubMedCrossRefGoogle Scholar
  18. 18.
    Kourilsky, O., Vandewalle, A., Smith, M.D., et al.: Persistent intravascular C3 activation after bilateral nephrectomy in patients with thrombotic microangiopathy. Clin nephrol 6: 417, 1976Google Scholar
  19. 19.
    Remuzzi, G., Livio, M., Mecca, G., et al.: Prostacyclin and kidney disease: Focus on uremia and thrombotic microangiopathy. In Lewis, P.J., and O’Grady, J. (eds.): Clinical Pharmacology of Prostacyclin. New York, Raven Press, 1981Google Scholar
  20. 20.
    Poschmann, A.: Neuraminidase-indzwierte Hamolyse. Mschr Kinderheilk 124: 15, 1976PubMedGoogle Scholar
  21. 21.
    Smith, C.D., Schuster, S.R., Gruppe, W.E., et al.: Hemolytic- uremic syndrome: A diagnostic and therapeutic dilemma for the surgeon. J Pediatr Surg 13: 597, 1978PubMedCrossRefGoogle Scholar
  22. 22.
    Whitington, P.F., Friedman, A.L., and Chesney, R.W.: Gastrointestinal disease in the hemolytic-uremic syndrome. Gastroenterology 76: 728, 1979PubMedGoogle Scholar
  23. 23.
    Kaplan, B.S. Hemolytic uremic syndrome with recurrent episodes: An important subset. Clin Nephrol 8: 495, 1977PubMedGoogle Scholar
  24. 24.
    Kaplan, B.S., Chesney, R.W., and Drummond, K.N.: Hemolytic uremic syndrome in families. N Engl J Med 292: 1090, 1975PubMedCrossRefGoogle Scholar
  25. 25.
    Karlsberg, R.P., Lacher, J.W., and Bartecchi, C.E.: Adult hemolytic- uremic syndrome. Arch Intern Med 137: 1155, 1977PubMedCrossRefGoogle Scholar
  26. 26.
    Hogewind, B.L., de la Riviere, G.B., van Es, L.A., et al.: Familial occurrence of the haemolytic uraemic syndrome. Acta Med Scand 207: 73, 1980PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1984

Authors and Affiliations

  • Bernard S. Kaplan
  • Paul R. Goodyer
  • Jack S. C. Fong
  • Peter D. Thomson

There are no affiliations available

Personalised recommendations