Calcium Channel Blockers and Limitation of Myocardial Infarction Size

  • Zoltan G. Turi
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 41)


Initial great enthusiasm for the use of calcium channel blocking agents in acute myocardial infarction (AMI) stems from the work of Oliva (1) in which 40% of patients catheterized immediately after onset of symptoms could be demonstrated to have restoration of flow through a previously occluded coronary vessel following the selective intracoronary injection of nitroglycerin. These findings coincided with those of Maseri (2) that some patients with reversible coronary vasospasm would eventually develop myocardial infarction in the same vascular distribution. Thus, drugs with potent coronary spasmolytic effect, such as calcium channel blocking agents, might be highly effective in restoring flow to infarcting areas of myocardium.


Acute Myocardial Infarction Infarct Size Acute Myocardial Infarction Collateral Blood Flow Calcium Channel Blockade 
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© Martinus Nijhoff Publishing, Boston 1984

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  • Zoltan G. Turi

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