Herpes Simplex Virus Thymidine Kinase-Dependent Antiviral Agents

  • Yung-Chi Cheng
Part of the Developments in Molecular Virology book series (DMVI, volume 4)


Herpes simplex virus type 1 (HSV-l), type 2 (HSV-2) and varicella zoster virus (VZV) are capable of inducing their specified thymidine kinase (TK) in virus-infected cells. These virus-specified thymidine kinases differ from human cytosol and mitochondrial thymidine kinases not only in their physical and immunological properties (Table 1) but also in their kinetic behaviors (1–8).


Herpes Simplex Virus Type Thymidine Kinase Varicella Zoster Virus Thymidine Phosphorylase Thymidine Analog 
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Copyright information

© Martinus Nijhoff Publishing, Boston 1984

Authors and Affiliations

  • Yung-Chi Cheng
    • 1
  1. 1.Department of Pharmacology and Medicinethe University of North CarolinaChapel HillUSA

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