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Activation of Cellular Onc (C-ONC) Genes: A Common Pathway for Oncogenesis

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Application of Biological Markers to Carcinogen Testing

Part of the book series: Environmental Science Research ((ESRH,volume 29))

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Abstract

Retroviruses can be classified into two groups: those that contain oncogenes, and those that do not (for reviews, see refs. 1–5). Members of the first group (acute, or rapidly transforming retroviruses) induce neoplastic disease in infected animals within a few weeks after infection, and cause rapid transformation of target cells in tissue culture. Viruses of the second group (slowly transforming retroviruses), which lack oncogenes, induce neoplastic disease in animals only after a long latent period (4–12 months), and do not cause transformation of tissue culture cells at detectable frequency.

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Author information

Authors and Affiliations

  1. Memorial Sloan-Kettering Cancer Center, 10021, New York, New York, USA

    W. S. Hayward, B. G. Neel, S. C. Jhanwar & R. S. K. Chaganti

Authors
  1. W. S. Hayward
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  2. B. G. Neel
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  3. S. C. Jhanwar
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  4. R. S. K. Chaganti
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Editors and Affiliations

  1. United States Environmental Protection Agency, Washington, D.C., USA

    Harry A. Milman

  2. University of Texas Health Science Center, Houston, Texas, USA

    Stewart Sell

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© 1983 Plenum Press, New York

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Hayward, W.S., Neel, B.G., Jhanwar, S.C., Chaganti, R.S.K. (1983). Activation of Cellular Onc (C-ONC) Genes: A Common Pathway for Oncogenesis. In: Milman, H.A., Sell, S. (eds) Application of Biological Markers to Carcinogen Testing. Environmental Science Research, vol 29. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3790-4_36

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  • DOI: https://doi.org/10.1007/978-1-4613-3790-4_36

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3792-8

  • Online ISBN: 978-1-4613-3790-4

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