Alphafetoprotein as a Marker for Early Events and Carcinoma Development During Chemical Hepatocarcinogenesis

  • S. Sell
  • F. Becker
  • H. Leffert
  • K. Osborn
  • J. Salman
  • B. Lombardi
  • H. Shinozuka
  • J. Reddy
  • E. Ruoslahti
  • J. Sala-Trepat
Part of the Environmental Science Research book series (ESRH, volume 29)


Animal bioassays for carcinogens depend on evaluation of morphologic changes in affected organs following carcinogen exposure. In rats and mice this procedure is expensive, and evaluation of the morphologic changes that occur before obvious cancer develops are subject to disagreement among pathologists. In particular, the reversible morphologic changes that occur in the liver upon exposure to chemical hepatocarcinogens have been given different interpretations by different pathologists (1–5). Terms used vary from “preneoplastic,” implying a lesion that will eventually develop into a cancer, to “hyperplastic” or “benign proliferative lesion,” which implies that it does not develop into cancer.


Oval Cell Primary Hepatocellular Carcinoma Bile Duct Proliferation Rapid Elevation Choline Deficient Diet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • S. Sell
    • 1
  • F. Becker
    • 2
  • H. Leffert
    • 3
  • K. Osborn
    • 1
  • J. Salman
    • 1
  • B. Lombardi
    • 4
  • H. Shinozuka
    • 4
  • J. Reddy
    • 5
  • E. Ruoslahti
    • 6
  • J. Sala-Trepat
    • 7
  1. 1.Department of Pathology and Laboratory MedicineUniversity of Texas Medical SchoolHoustonUSA
  2. 2.M.D. Anderson Hospital and Tumor InstituteHoustonUSA
  3. 3.University of California at San DiegoSan DiegoUSA
  4. 4.University of PittsburghPittsburghUSA
  5. 5.Northwestern University Medical SchoolChicagoUSA
  6. 6.LaJolla Cancer Research FoundationLaJollaUSA
  7. 7.Laboratoire d’Enzymologie du C.N.R.S.Gif. sur-Yvette

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