Alphafetoprotein as a Marker for Early Events and Carcinoma Development During Chemical Hepatocarcinogenesis

  • S. Sell
  • F. Becker
  • H. Leffert
  • K. Osborn
  • J. Salman
  • B. Lombardi
  • H. Shinozuka
  • J. Reddy
  • E. Ruoslahti
  • J. Sala-Trepat
Part of the Environmental Science Research book series (ESRH, volume 29)

Abstract

Animal bioassays for carcinogens depend on evaluation of morphologic changes in affected organs following carcinogen exposure. In rats and mice this procedure is expensive, and evaluation of the morphologic changes that occur before obvious cancer develops are subject to disagreement among pathologists. In particular, the reversible morphologic changes that occur in the liver upon exposure to chemical hepatocarcinogens have been given different interpretations by different pathologists (1–5). Terms used vary from “preneoplastic,” implying a lesion that will eventually develop into a cancer, to “hyperplastic” or “benign proliferative lesion,” which implies that it does not develop into cancer.

Keywords

Choline Pyrene Laminin Noma Aldolase 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Farber, E. (1973) Meth. Cancer Res. 7:345.Google Scholar
  2. 2.
    Squire, R.A., and M.H. Levitt (1975) Cancer Res. 35:3214.Google Scholar
  3. 3.
    Schueler, R.L., et al. (1980) Proceedings of a Mouse Liver Tumor Workshop, Silver Spring, Maryland, June 11–13.Google Scholar
  4. 4.
    Becker, F.F. (1982) Cancer Res. 42:3918.Google Scholar
  5. 5.
    Sell, S., and H.L. Leffert (1982) Hepatology 2:77.CrossRefGoogle Scholar
  6. 6.
    Farber, E., et. al. (1979) In Carcinogens: Identification and Mechanisms of Action, A.C. Griffin and C.R. Shaw, eds. Raven Press, New York, p. 319.Google Scholar
  7. 7.
    Ames, B.N., W.E. Durston, E. Yamasaki, and F.D. Lee (1973) Proc. Natl. Acad. Sci., USA 70:2281.ADSCrossRefGoogle Scholar
  8. 8.
    Heidelberger, C. (1973) Adv. Cancer Res. 18:317.CrossRefGoogle Scholar
  9. 9.
    Skehan, P., and S.J. Friedman (1981) In The Transformed Cell, Academic Press, New York, pp. 7–65.Google Scholar
  10. 10.
    Sell, S. (1980) Cancer Markers, Vol. I, Humana Press, Clifton, New Jersey.CrossRefGoogle Scholar
  11. 11.
    Sell, S., and B. Wahren, eds. (1982) Cancer Markers, Vol. II, Humana Press, Clifton, New Jersey.Google Scholar
  12. 12.
    Sell, S., F.F. Becker, B. Lombardi, H. Shinozuka, and J. Reddy(1979) In Carcino-Embryonic Proteins, Vol. I, F.-G. Lehmann, ed. Elsevier/North Holland Biomed. Press, p. 129.Google Scholar
  13. 13.
    Kinosita, R. (1937) Trans. Soc. Path. Jap. 27:665.Google Scholar
  14. 14.
    Farber, E. (1956) Cancer Res. 16:142.Google Scholar
  15. 15.
    Reuber, M.D. (1965) J. Natl. Cancer lnst. 34:697.Google Scholar
  16. 16.
    Teebor, G.W., and F.F. Becker (1971) Cancer Res. 31:1.Google Scholar
  17. 17.
    Becker, F.F., and S. Sell (1974) Cancer Res. 34:2489.Google Scholar
  18. 18.
    DeBaun, J.R., E.C. Miller, and J.A. Miller (1970) Cancer Res. 30:577.Google Scholar
  19. 19.
    Gutmann, H.R., D. Malejka-Giganti, E.J. Barry, and R.E. Rydell (1972) Cancer Res. 32:1554.Google Scholar
  20. 20.
    Jackson, C.D., and C.C. Irving (1972) Cancer Res. 32:1590.Google Scholar
  21. 21.
    Becker, F.F., and S. Sell (1979) Cancer Res. 39:1437.Google Scholar
  22. 22.
    Leffert, H.L., and D. Paul (1973) J. Cell. Physiol. 81:113.CrossRefGoogle Scholar
  23. 23.
    Sell, S., H.L. Leffert, H. Skelly, V. Muller-Eberhard, and S. Kida (1975) Ann. N.Y. Acad. Sci. 259:45.ADSCrossRefGoogle Scholar
  24. 24.
    Koch, K.S., and H.L. Leffert (1980) Ann. N.Y. Acad. Sci. 349:111.ADSCrossRefGoogle Scholar
  25. 25.
    Sell, S. (1978) Cancer Res. 38:3107.Google Scholar
  26. 26.
    Lombardi, B., and H. Shinozuka (1979) Int. J. Cancer 23:565.CrossRefGoogle Scholar
  27. 27.
    Shinozuka, H., B. Lombardi, S. Sell, and R.M. Iammarino (1978) J. Natl. Cancer. Inst. 61:813.Google Scholar
  28. 28.
    Shinozuka, H., M.A. Sells, S.L. Katyal, S. Sell, and B. Lombardi (1979) Cancer Res. 39:2515.Google Scholar
  29. 29.
    Sell, S., H.L. Leffert, H. Shinozuka, B. Lombardi, and N. Gochman (1981) Gann 72:479.Google Scholar
  30. 30.
    Sell, S., K. Osborn, and H.L. Leffert (1981) Carcinogenesis 2:7.CrossRefGoogle Scholar
  31. 31.
    Sell, S., and E. Ruoslahti (1982) J. Natl. Can. Inst. 69:1105.Google Scholar
  32. 32.
    Sarcione, E. (1972) In Embryonic and Fetal Antigens in Cancer, Vol 2, N.G. Anderson, J.N. Coggin, E. Cole, and J.W. Hallerman, eds. Oak Ridge National Laboratory, Oak Ridge, Tennessee, pp. 323–328.Google Scholar
  33. 33.
    Hudig, D., S. Sell, L. Newell, and F.F. Becker (1979) Cancer Res. 39:3715.Google Scholar
  34. 34.
    Shinozuka, H., B. Lombardi, S. Sell, and R.M. Iammarino (1978) Cancer Res. 38:1092.Google Scholar
  35. 35.
    Shinozuka, H., B. Lombardi, S. Sell, R.M. Iammarino (1978) J. Natl. Cancer Inst. 61:813.Google Scholar
  36. 36.
    Becker, F.F., A.A. Horland, A. Shurgin, and S. Sell (1975) Cancer Res. 35:1510.Google Scholar
  37. 37.
    Shinozuka, H., M.A. Sells, S.L. Katyal, S. Sell, and B. Lombardi (1979) Cancer Res. 39:2515.Google Scholar
  38. 38.
    Reddy, J.K., M.S. Rao, D.L. Azarnoff, and S. Sell (1979) Cancer Res. 39:152.Google Scholar
  39. 39.
    Grisham, J.W., and W.S. Hartroft (1961) Lab. Investig. 10:317.Google Scholar
  40. 40.
    Schaffner, F., and H. Popper (1961) Am. J. Pathol. 38:393.Google Scholar
  41. 41.
    Grisham, J.W., and E.A. Porta (1964) Exp. Mal. Path. 3:242.CrossRefGoogle Scholar
  42. 42.
    Fukusmima, S., M. Shibata, T. Hibino, T. Yoshimura, M. Hirose, and N. Ito (1979) Toxicol. App. Pharm. 48:145.CrossRefGoogle Scholar
  43. 43.
    Sell, S. (in press) Cancer Res.Google Scholar
  44. 44.
    Becker, F.F., D. Stillman, and S. Sell (1977) Cancer Res. 37:870.Google Scholar
  45. 45.
    Jalanko, H., I. Virtauen, E. Engvall, and E. Ruoslahti (1978) Int. J. Cancer 21:453.CrossRefGoogle Scholar
  46. 46.
    Becker, F.F. and S. Sell (1979) Cancer Res. 39:3491.Google Scholar
  47. 47.
    Jalanko, H., and E. Ruoslahti (1979) Cancer Res. 39:3495.Google Scholar
  48. 48.
    Princler, G.L., G. Vlahakis, K.H. Kortright, S. Okada, and K.R. McIntire (1981) Eur. J. Cancer Clin. Oncol. 17:1241.CrossRefGoogle Scholar
  49. 49.
    Shinozuka, H., S.L. Katyal, and B. Lombardi (1978) Int. J. Cancer 22:36.CrossRefGoogle Scholar
  50. 50.
    Boyd, J.N., N. Misslbeck, J.G. Babish, T.C. Campbell, and G.S. Stoewsand (1981) Drug. Chem. Tox. 4:197.CrossRefGoogle Scholar
  51. 51.
    Sala-Trepat, J.M., T.D. Sargent, S. Sell, and J. Bonner (1979) Proc. Natl. Acad. Sci., USA 76:695.ADSCrossRefGoogle Scholar
  52. 52.
    Sell, S., K. Thomas, M. Michaelsen, J. Sala-Trepat, and J. Bonner (1979) Biochem. Biophys. Acta 564:173.Google Scholar
  53. 53.
    Sala-Trepat, J.M., J. Dever, T.D. Sargent, K. Thomas, S. Sell, and J. Bonner (1979) Biochemistry 18:2167.CrossRefGoogle Scholar
  54. 54.
    Nahon, J.-L., A. Gal, M. Franin, S. Sell, and J.M. Sala-Trepat (1982) Nucleic Acids Res. 10:1895.Google Scholar
  55. 55.
    Sell, S., J. Sala-Trepat, T. Sargent, K. Thomas, J.-L. Nahon, T. Goodman, and J. Bonner (1980) Cell BioI. Int. Reports 4:235CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • S. Sell
    • 1
  • F. Becker
    • 2
  • H. Leffert
    • 3
  • K. Osborn
    • 1
  • J. Salman
    • 1
  • B. Lombardi
    • 4
  • H. Shinozuka
    • 4
  • J. Reddy
    • 5
  • E. Ruoslahti
    • 6
  • J. Sala-Trepat
    • 7
  1. 1.Department of Pathology and Laboratory MedicineUniversity of Texas Medical SchoolHoustonUSA
  2. 2.M.D. Anderson Hospital and Tumor InstituteHoustonUSA
  3. 3.University of California at San DiegoSan DiegoUSA
  4. 4.University of PittsburghPittsburghUSA
  5. 5.Northwestern University Medical SchoolChicagoUSA
  6. 6.LaJolla Cancer Research FoundationLaJollaUSA
  7. 7.Laboratoire d’Enzymologie du C.N.R.S.Gif. sur-Yvette

Personalised recommendations