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Ornithine Decarboxylase: Alterations In Carcinogenesis

  • Chapter
Application of Biological Markers to Carcinogen Testing

Part of the book series: Environmental Science Research ((ESRH,volume 29))

Abstract

The diamine putrescine, the tertiary amine spermidine, and the quaternary amine spermine (collectively referred to as the polyamines) are small, aliphatic, nonprotein nitrogenous bases found in all living cells (1,2). Because of their polycationic nature, they can form tight, noncovalent complexes with negatively charged cellular constituents, such as nucleic acids and proteins. This electrostatic binding is the basis of the known essential roles that polyamines play in nucleic acid and protein synthesis, structure, and function (3,4). In contrast to the inorganic cations, which must be supplied to the cell by the circulation, the polyamines can be synthesized by the cells at times of cellular need. The primary mechanism for a cellular increase in polyamine content is an increase in the activity of ornithine decarboxylase (ODC) which catalyzes the formation of putrescine from ornithine.

Suppported by NIT Grant CA32444.

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Author information

Authors and Affiliations

  1. Departments of Internal Medicine and Pharmacology, University of Texas Medical School, 77025, Houston, Texas, USA

    Mari K. Haddox & Anne R. L. Greenfield

Authors
  1. Mari K. Haddox
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  2. Anne R. L. Greenfield
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Editors and Affiliations

  1. United States Environmental Protection Agency, Washington, D.C., USA

    Harry A. Milman

  2. University of Texas Health Science Center, Houston, Texas, USA

    Stewart Sell

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© 1983 Plenum Press, New York

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Haddox, M.K., Greenfield, A.R.L. (1983). Ornithine Decarboxylase: Alterations In Carcinogenesis. In: Milman, H.A., Sell, S. (eds) Application of Biological Markers to Carcinogen Testing. Environmental Science Research, vol 29. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3790-4_18

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  • DOI: https://doi.org/10.1007/978-1-4613-3790-4_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3792-8

  • Online ISBN: 978-1-4613-3790-4

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