Abstract
Classical activation of the complement system is initiated by the binding of C1 to immune complexes or aggregated IgG1. It is generally assumed that the binding site for the complement subcomponent C1q resides on the Cγ2 domain. However, a convincing picture of the precise topography and chemical nature of the complement binding site is still lacking.
The data presented in this communication have been originally published in Molecular Immunology12.
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© 1983 Plenum Press, New York
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Bragado, R., López de Castro, J.A., Ortiz, F., Vivanco, F. (1983). Human Fcγ Fragment: Location of Acidic Residues Involved in Complement Activation. In: Celada, F., Schumaker, V.N., Sercarz, E.E. (eds) Protein Conformation as an Immunological Signal. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3778-2_9
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