Antigen Presenting Function of Macrophages

  • C. Shirley Lin
  • Ted. H. Hansen
  • Lanny T. Rosenwasser
  • Brigitte T. Huber
  • Alan S. Rosenthal

Abstract

The immune response to many natural and synthetic protein antigens has been shown to be controlled by genes (Ir) linked to the major histocompatibility complex (MHC). Animals possessing Ir genes can elicit a strong immune response against a particular antigen. Animals lacking the specific Ir gene are deficient in either humoral or cellular immunity. Ir genes were shown to control only T cell mediated responses to T-dependent antigens1. Antibody production was affected secondarily as a result of this impaired T cell — B cell interaction. Responses to T-independent antigens which activate B lymphoctes directly are not under Ir gene control.

Keywords

Heparin Tuberculosis Polypeptide Alanine Nylon 

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • C. Shirley Lin
    • 1
  • Ted. H. Hansen
    • 1
  • Lanny T. Rosenwasser
    • 2
  • Brigitte T. Huber
    • 2
  • Alan S. Rosenthal
    • 1
  1. 1.Department of ImmunologyMerch Sharp & Dohme Research LaboratoriesRathwayUSA
  2. 2.The Allergy Division, Department of Medicine & Department of Pathology, Cancer Research CenterTufts University School of MedicineBostonUSA

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