Antigen Presenting Function of Macrophages

  • C. Shirley Lin
  • Ted. H. Hansen
  • Lanny T. Rosenwasser
  • Brigitte T. Huber
  • Alan S. Rosenthal


The immune response to many natural and synthetic protein antigens has been shown to be controlled by genes (Ir) linked to the major histocompatibility complex (MHC). Animals possessing Ir genes can elicit a strong immune response against a particular antigen. Animals lacking the specific Ir gene are deficient in either humoral or cellular immunity. Ir genes were shown to control only T cell mediated responses to T-dependent antigens1. Antibody production was affected secondarily as a result of this impaired T cell — B cell interaction. Responses to T-independent antigens which activate B lymphoctes directly are not under Ir gene control.


Proliferative Response Thymidine Incorporation Purify Protein Derivative Normal Mouse Seron Antigen Present Function 
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  1. 1.
    B. Benacerraf and H. O. McDevitt, Science 175: 273 (1972).PubMedCrossRefGoogle Scholar
  2. 2.
    H. von Boehmer, W. Hass and N. K. Jerne, Proc. Natl. Acad. Sci. USA 75: 2439 (1978).CrossRefGoogle Scholar
  3. 3.
    A. S. Rosenthal, Immunological Reviews 40: 136 (1978).PubMedCrossRefGoogle Scholar
  4. 4.
    E. M. Shevach and A. S. Rosenthal, J. Exp. Med. 138: 1213 (1973).PubMedCrossRefGoogle Scholar
  5. 5.
    R. H. Schwartz, C. S. David, M. E. Dorf and B. Benacerraf, Proc. Natl. Acad. Sci. USA 75: 2387 (1978).PubMedCrossRefGoogle Scholar
  6. 6.
    L. J. Rosenwasser, R. S. Bhatnager and J. D. Stobo, J. Immunol. 124: 2854 (1978).Google Scholar
  7. 7.
    L. J. Rosenwasser and A. S. Rosenthal, J. Immunol. 120: 1991 (1978).PubMedGoogle Scholar
  8. 8.
    B. T. Huber, Proc. Natl. Acad. Sci. USA 76: 3460 (1979).PubMedCrossRefGoogle Scholar
  9. 9.
    I. F. C. McKenzie, G. M. Morgan, M. S. Sandrin, M. M. Michaelides, R. W. Melvold and H. I. Kohn, J. Exp. Med. 160: 1323 (1979).CrossRefGoogle Scholar
  10. 10.
    T. H. Hansen, R. W. Melvold, J. S. Am and D. H. Sachs, Nature (London) 285: 340 (1980).CrossRefGoogle Scholar
  11. 11.
    L. P. de Waal, C. T. M. Melief and R. W. Melvold, Eur. J. Immunol. 11: 258 (1981).Google Scholar
  12. 12.
    G. M. Morgan, I. F. C. McKenzie and R. W. Melvold, Immunogenet. 11: 1 (1980).CrossRefGoogle Scholar
  13. 13.
    D. J. McKean, R. Melvold and C. David, Immunogenet., in press (1981).Google Scholar
  14. 14.
    C. S. Lin, A. S. Rosenthal, H. C. Passmore and T. H. Hansen, Proc. Natl. Acad. Sci. 78: 6406 (1981).PubMedCrossRefGoogle Scholar
  15. 15.
    L. J. Rosenwasser, M. A. Barcinski, R. H. Schwartz and A. S. Rosenthal, J. Immunol. 123: 471 (1979).PubMedGoogle Scholar
  16. 16.
    M. E. Dord, Springer Seminars in Immunopathology 1: 171 (1978).CrossRefGoogle Scholar
  17. 17.
    A. M. Solinger and R. H. Schwartz, J. Immunol. 124: 2485 (1980).PubMedGoogle Scholar
  18. 18.
    M. Michaelides, M. Sandrin, G. Morgan, I. F. C. McKenzie, R. Ashman and R. W. Melvold, J. Exp. Med. 153: 464 (1981).PubMedCrossRefGoogle Scholar
  19. 19.
    C. G. Fathman, M. Kimoto, R. Melvold and C. David, Proc. Natl. Acad. Sci. 78: 1853 (1981).PubMedCrossRefGoogle Scholar
  20. 20.
    E. A. Lerner, L. A. Matis, C. A. Janeway Jr., P. P. Jones, R. H. Schwartz and D. B. Murphy, J. Exp. Med. 152: 1085 (1980).PubMedCrossRefGoogle Scholar
  21. 21.
    R. H. Schwartz, M. E. Dorf, B. Benacerraf and W. E. Paul, J. Exp. Med. 143: 897 (1976).PubMedCrossRefGoogle Scholar
  22. 22.
    R. H. Schwartz, A. Yano, J. H. Stimpfling and W. E. Paul, J. Exp. Med. 149: 40 (1979).PubMedCrossRefGoogle Scholar
  23. 23.
    D. L. Longo and R. H. Schwartz, J. Exp. Med. 151: 1452 (1980).PubMedCrossRefGoogle Scholar
  24. 24.
    B. T. Huber, T. H. Hansen and D. A. Thorley-Lawson, Fed. Proc. 40: 4135 (1981).Google Scholar
  25. 25.
    B. T. Huber, R. K. Gershon and H. Cantor, J. Exp. Med. 145: 10 (1977).PubMedCrossRefGoogle Scholar
  26. 26.
    A. Ahmed, I. Scher, S. O. Sharrow, A. H. Smith, W. E. Paul, D. H. Sachs and K. W. Sell, J. Exp. Med. 145: 101 (1977).PubMedCrossRefGoogle Scholar
  27. 27.
    B. Subbarao, D. E. Mosier, A. Ahmed, J. J. Mond, I. Scher and W. E. Paul, J. Exp. Med. 149: 495 (1979).PubMedCrossRefGoogle Scholar
  28. 28.
    L. J. Rosenwasser and B. T. Huber, J. Exp. Med. 153: 1113 (1981).PubMedCrossRefGoogle Scholar
  29. 29.
    T. H. Huber and D. A. Thorley-Lawson, Proc. Natl. Acad Sci., in press (1981).Google Scholar
  30. 30.
    R. H. Schwartz, C. S. David, D. H. Sachs and W. E. Paul, J. Immunol. 117: 531 (1976).PubMedGoogle Scholar
  31. 31.
    D. W. Thomas, U. Yamashita and E, M. Shevach, J. Immunol. 119: 223 (1977).PubMedGoogle Scholar
  32. 32.
    E. M. Shevach, Springer Sem. Immunopathol. 1: 207 (1978).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • C. Shirley Lin
    • 1
  • Ted. H. Hansen
    • 1
  • Lanny T. Rosenwasser
    • 2
  • Brigitte T. Huber
    • 2
  • Alan S. Rosenthal
    • 1
  1. 1.Department of ImmunologyMerch Sharp & Dohme Research LaboratoriesRathwayUSA
  2. 2.The Allergy Division, Department of Medicine & Department of Pathology, Cancer Research CenterTufts University School of MedicineBostonUSA

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