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Activation of Mammalian Complement by Chicken C1q

  • Else Marie Nicolaisen

Abstract

Activation of chicken complement by the classical pathway is still debatable. Both positive and negative evidence of antibody dependent lysis has been reported. The components from C3 to C9 function since activation via the alternative pathway will lyse mammalian erythrocytes in the absence of Ig. Actually the discrepancy in the literature concerning classical activation might be explained by the fact that heterologous erythrocytes were used in most studies. On the other hand, absence of lysis of chicken erythrocytes coated with specific chicken antibodies might be due to the strong anti-complementary effect ascribed to chicken serum.

Keywords

Human Complement Chicken Erythrocyte Chicken Serum Chicken Antibody Soluble Fibronectin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Else Marie Nicolaisen
    • 1
  1. 1.Institute for Experimental ImmunologyUniversity of CopenhagenCopenhagen ØDenmark

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