Specific Locus Mutations in the Monitoring of Human Populations for Genetic Damage
My primary argument in this paper is that in terms of the genetic monitoring of human populations, induced somatic mutation must be our major future concern. This is not to say that germ cell effects in humans are medically trivial. It is simply to say that the best evidence we now have is that somatic mutation may be a major cause of disease, particularly in genetically at-risk persons. We have no such evidence for the effects of induced germinal mutations in man; and I would, therefore, submit that our focus in future research efforts should be the identification of these genetically at-risk individuals.
KeywordsChromosomal Aberration Fanconi Anemia Sister Chromatid Exchange Childhood Leukemia Genetic Damage
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