Abstract
The specific locus method for determining mutagenicity in vivo has been used very successfully for over 30 years and doubtless will continue to be used for many years to come. It has the great advantage of giving clear-cut results in the F1 generation. Another advantage in my opinion is that it can be treated as a kind of “basic kit” to which all sorts of other useful tests and analyses of the F1 generation can be added on. These include searches for various kinds of dominant mutation, or for specific biochemical defects, as well as fertility tests to look for the presence of translocations or other chromosome anomalies. Thus, by building on to this one test, some idea of the nature and magnitude of the extra genetic load associated with particular mutagenic exposure can be obtained.
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Searle, A.G. (1983). Some Ideas on Future Test Systems. In: de Serres, F.J., Sheridan, W. (eds) Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk. Environmental Science Research, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3739-3_18
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DOI: https://doi.org/10.1007/978-1-4613-3739-3_18
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